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- W3045595966 startingPage "2101" @default.
- W3045595966 abstract "The prolonged storage of glucose as glycogen can promote the quiescence of tumor cells, whereas the accumulation of an aberrant form of glycogen without the primer protein glycogenin can induce the metabolic switch towards a glycolytic phenotype. Here, we analyzed the expression of n = 67 genes involved in glycogen metabolism on the uveal melanoma (UM) cohort of the Cancer Genome Atlas (TCGA) study and validated the differentially expressed genes in an independent cohort. We also evaluated the glycogen levels with regard to the prognostic factors via a differential periodic acid-Schiff (PAS) staining. UMs with monosomy-3 exhibited a less glycogenetic and more insulin-resistant gene expression profile, together with the reduction of glycogen levels, which were associated with the metastases. Expression of glycogenin-1 (Locus: 3q24) was lower in the monosomy-3 tumors, whereas the complementary isoform glycogenin-2 (Locus: Xp22.33) was upregulated in females. Remarkably, glycogen was more abundant in the monosomy-3 tumors of male versus female patients. We therefore provide the first evidence to the dysregulation of glycogen metabolism as a novel factor that may be aggravating the course of UM particularly in males." @default.
- W3045595966 created "2020-08-03" @default.
- W3045595966 creator A5010478151 @default.
- W3045595966 creator A5020684039 @default.
- W3045595966 creator A5028056694 @default.
- W3045595966 creator A5044037873 @default.
- W3045595966 creator A5058464254 @default.
- W3045595966 creator A5062527699 @default.
- W3045595966 creator A5082233866 @default.
- W3045595966 date "2020-07-29" @default.
- W3045595966 modified "2023-09-29" @default.
- W3045595966 title "Metastasis of Uveal Melanoma with Monosomy-3 Is Associated with a Less Glycogenetic Gene Expression Profile and the Dysregulation of Glycogen Storage" @default.
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