FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045636161> ?p ?o ?g. }

• W3045636161 endingPage "9" @default.
• W3045636161 startingPage "1" @default.
• W3045636161 abstract "Background: We aimed to determine the role of receptor tyrosine kinases (RTK) signaling family genes in the development of oral squamous cell carcinoma (OSCC). Method: In the present in silico study, 40 whole genome sequences of patients with OSCC from the cBioPortal was analysed to identify the mutations in the genes of the RTK signaling pathway. Using the STRING v10.5, we further checked the gene with the highest frequency of mutations for its protein interactions. The obtained protein interaction network was used to identify the possible pathways related to disease phenotype. Results: Epidermal growth factor receptor (EGFR) gene showed the highest frequency of mutation (5%) among the 16 genes clustered in the RTK signaling pathway as available in the cBioportal database. Missense mutations viz., G203E, R521K were identified in the EGFR gene. The other genes which returned positive results during analysis were ERBB4 (D245N, L993S), PDGFB (R100H), and PDGFRB (L667M). Conclusion: The in silico method of analysis can be a contemporary approach for identifying possible mutations or pathways associated with the development of OSCC. Further high throughput strategies should be applied to substantiate the role of the genes identified in the present study and draw conclusive evidence as to their association with the disease phenotype." @default.
• W3045636161 created "2020-08-03" @default.
• W3045636161 creator A5002141204 @default.
• W3045636161 creator A5041770957 @default.
• W3045636161 creator A5046507371 @default.
• W3045636161 creator A5058621209 @default.
• W3045636161 date "2021-01-01" @default.
• W3045636161 modified "2023-09-24" @default.
• W3045636161 title "A Computational Approach to Identify the Mutations in the Genes of the RTK Signaling Pathway and their Possible Association with Oral Squamous Cell Carcinoma" @default.
• W3045636161 cites W1965417071 @default.
• W3045636161 cites W1968265559 @default.
• W3045636161 cites W2013556445 @default.
• W3045636161 cites W2024473187 @default.
• W3045636161 cites W2032359283 @default.
• W3045636161 cites W2033338244 @default.
• W3045636161 cites W2074624949 @default.
• W3045636161 cites W2078204613 @default.
• W3045636161 cites W2082937679 @default.
• W3045636161 cites W2087898932 @default.
• W3045636161 cites W2096249701 @default.
• W3045636161 cites W2102639464 @default.
• W3045636161 cites W2102769930 @default.
• W3045636161 cites W2114843025 @default.
• W3045636161 cites W2116555647 @default.
• W3045636161 cites W2120364751 @default.
• W3045636161 cites W2121149237 @default.
• W3045636161 cites W2122997780 @default.
• W3045636161 cites W2123702372 @default.
• W3045636161 cites W2128961154 @default.
• W3045636161 cites W2136513422 @default.
• W3045636161 cites W2142076829 @default.
• W3045636161 cites W2149434165 @default.
• W3045636161 cites W2149441684 @default.
• W3045636161 cites W2150256054 @default.
• W3045636161 cites W2170429308 @default.
• W3045636161 cites W2175146729 @default.
• W3045636161 cites W2256016639 @default.
• W3045636161 cites W2537623931 @default.
• W3045636161 cites W2550850767 @default.
• W3045636161 cites W2579149933 @default.
• W3045636161 cites W2613613490 @default.
• W3045636161 cites W2735655169 @default.
• W3045636161 cites W2751913252 @default.
• W3045636161 cites W2806079143 @default.
• W3045636161 cites W58289801 @default.
• W3045636161 cites W2187129059 @default.
• W3045636161 doi "https://doi.org/10.30476/mejc.2020.82336.1079" @default.
• W3045636161 hasPublicationYear "2021" @default.
• W3045636161 type Work @default.
• W3045636161 sameAs 3045636161 @default.
• W3045636161 citedByCount "0" @default.
• W3045636161 crossrefType "journal-article" @default.
• W3045636161 hasAuthorship W3045636161A5002141204 @default.
• W3045636161 hasAuthorship W3045636161A5041770957 @default.
• W3045636161 hasAuthorship W3045636161A5046507371 @default.
• W3045636161 hasAuthorship W3045636161A5058621209 @default.
• W3045636161 hasConcept C101544691 @default.
• W3045636161 hasConcept C104317684 @default.
• W3045636161 hasConcept C121608353 @default.
• W3045636161 hasConcept C127716648 @default.
• W3045636161 hasConcept C170493617 @default.
• W3045636161 hasConcept C180361614 @default.
• W3045636161 hasConcept C2775905019 @default.
• W3045636161 hasConcept C2775960820 @default.
• W3045636161 hasConcept C2779438470 @default.
• W3045636161 hasConcept C2780545995 @default.
• W3045636161 hasConcept C2780943970 @default.
• W3045636161 hasConcept C501734568 @default.
• W3045636161 hasConcept C502942594 @default.
• W3045636161 hasConcept C54355233 @default.
• W3045636161 hasConcept C60644358 @default.
• W3045636161 hasConcept C62478195 @default.
• W3045636161 hasConcept C70721500 @default.
• W3045636161 hasConcept C71924100 @default.
• W3045636161 hasConcept C75563809 @default.
• W3045636161 hasConcept C78221974 @default.
• W3045636161 hasConcept C86803240 @default.
• W3045636161 hasConceptScore W3045636161C101544691 @default.
• W3045636161 hasConceptScore W3045636161C104317684 @default.
• W3045636161 hasConceptScore W3045636161C121608353 @default.
• W3045636161 hasConceptScore W3045636161C127716648 @default.
• W3045636161 hasConceptScore W3045636161C170493617 @default.
• W3045636161 hasConceptScore W3045636161C180361614 @default.
• W3045636161 hasConceptScore W3045636161C2775905019 @default.
• W3045636161 hasConceptScore W3045636161C2775960820 @default.
• W3045636161 hasConceptScore W3045636161C2779438470 @default.
• W3045636161 hasConceptScore W3045636161C2780545995 @default.
• W3045636161 hasConceptScore W3045636161C2780943970 @default.
• W3045636161 hasConceptScore W3045636161C501734568 @default.
• W3045636161 hasConceptScore W3045636161C502942594 @default.
• W3045636161 hasConceptScore W3045636161C54355233 @default.
• W3045636161 hasConceptScore W3045636161C60644358 @default.
• W3045636161 hasConceptScore W3045636161C62478195 @default.
• W3045636161 hasConceptScore W3045636161C70721500 @default.
• W3045636161 hasConceptScore W3045636161C71924100 @default.
• W3045636161 hasConceptScore W3045636161C75563809 @default.
• W3045636161 hasConceptScore W3045636161C78221974 @default.
• W3045636161 hasConceptScore W3045636161C86803240 @default.

• next