Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045644504> ?p ?o ?g. }
- W3045644504 endingPage "5419" @default.
- W3045644504 startingPage "5407" @default.
- W3045644504 abstract "Insulin fibril formation is considered as the hallmark of several debilitating pathological conditions. To develop effective therapeutics that are able to control the amyloidogenesis process and inhibit fibril formation, herein we have designed a side-chain proline (Pro)-based homopolymer and block copolymers through the reversible addition-fragmentation chain transfer (RAFT) polymerization technique and further explored their obligatory role in the in vitro insulin fibrillation process. Using a variety of biophysical tools, including turbidity measurements, thioflavin T (ThT) fluorescence kinetics, tyrosine (Tyr) fluorescence study, Nile red (NR) fluorescence assay, dynamic light scattering (DLS) study, circular dichroism (CD) measurements, and isothermal titration calorimetry (ITC) techniques, we demonstrated that Pro-based polymers can significantly inhibit the insulin fibrillation process. Among them, the Pro-based homopolymer acts as the most potent inhibitor of insulin fibrillation as confirmed by ThT assay, CD study, and transmission electron microscopic (TEM) analysis. Tyrosine fluorescence measurements and NR fluorescence assay revealed that hydrophobic interactions are the crucial factor that mainly controls the inhibition process. Apart from hydrophobic interactions, polar interactions may also be responsible for the inhibition process as evaluated by ITC study." @default.
- W3045644504 created "2020-08-03" @default.
- W3045644504 creator A5003907679 @default.
- W3045644504 creator A5017282697 @default.
- W3045644504 creator A5020971229 @default.
- W3045644504 creator A5054354024 @default.
- W3045644504 creator A5068544237 @default.
- W3045644504 date "2020-07-27" @default.
- W3045644504 modified "2023-10-14" @default.
- W3045644504 title "Side-Chain Proline-Based Polymers as Effective Inhibitors for In Vitro Aggregation of Insulin" @default.
- W3045644504 cites W1972575833 @default.
- W3045644504 cites W1978554326 @default.
- W3045644504 cites W1978760666 @default.
- W3045644504 cites W1980251868 @default.
- W3045644504 cites W1990975843 @default.
- W3045644504 cites W1992722956 @default.
- W3045644504 cites W1994307930 @default.
- W3045644504 cites W1995247791 @default.
- W3045644504 cites W1998205923 @default.
- W3045644504 cites W2001363066 @default.
- W3045644504 cites W2001974127 @default.
- W3045644504 cites W2002559713 @default.
- W3045644504 cites W2010462701 @default.
- W3045644504 cites W2011825508 @default.
- W3045644504 cites W2015204917 @default.
- W3045644504 cites W2018161920 @default.
- W3045644504 cites W2027465873 @default.
- W3045644504 cites W2029172217 @default.
- W3045644504 cites W2034376929 @default.
- W3045644504 cites W2038399240 @default.
- W3045644504 cites W2046884231 @default.
- W3045644504 cites W2050492475 @default.
- W3045644504 cites W2052912339 @default.
- W3045644504 cites W2056673173 @default.
- W3045644504 cites W2061275832 @default.
- W3045644504 cites W2061627162 @default.
- W3045644504 cites W2072110387 @default.
- W3045644504 cites W2074244507 @default.
- W3045644504 cites W2075356582 @default.
- W3045644504 cites W2076334645 @default.
- W3045644504 cites W2076351952 @default.
- W3045644504 cites W2078040293 @default.
- W3045644504 cites W2083362712 @default.
- W3045644504 cites W2096532617 @default.
- W3045644504 cites W2102590723 @default.
- W3045644504 cites W2106275356 @default.
- W3045644504 cites W2109558113 @default.
- W3045644504 cites W2124869972 @default.
- W3045644504 cites W2129320185 @default.
- W3045644504 cites W2129575776 @default.
- W3045644504 cites W2141236092 @default.
- W3045644504 cites W2145336679 @default.
- W3045644504 cites W2152278845 @default.
- W3045644504 cites W2156215695 @default.
- W3045644504 cites W2158977717 @default.
- W3045644504 cites W2161976814 @default.
- W3045644504 cites W2169280166 @default.
- W3045644504 cites W2175266630 @default.
- W3045644504 cites W2203703674 @default.
- W3045644504 cites W2210448351 @default.
- W3045644504 cites W2258409964 @default.
- W3045644504 cites W2470253973 @default.
- W3045644504 cites W2551295498 @default.
- W3045644504 cites W2584157246 @default.
- W3045644504 cites W2588943247 @default.
- W3045644504 cites W2765216887 @default.
- W3045644504 cites W2785480706 @default.
- W3045644504 cites W2894335672 @default.
- W3045644504 cites W2901698459 @default.
- W3045644504 cites W2908806940 @default.
- W3045644504 cites W3010515603 @default.
- W3045644504 doi "https://doi.org/10.1021/acsabm.0c00709" @default.
- W3045644504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35021714" @default.
- W3045644504 hasPublicationYear "2020" @default.
- W3045644504 type Work @default.
- W3045644504 sameAs 3045644504 @default.
- W3045644504 citedByCount "23" @default.
- W3045644504 countsByYear W30456445042020 @default.
- W3045644504 countsByYear W30456445042021 @default.
- W3045644504 countsByYear W30456445042022 @default.
- W3045644504 countsByYear W30456445042023 @default.
- W3045644504 crossrefType "journal-article" @default.
- W3045644504 hasAuthorship W3045644504A5003907679 @default.
- W3045644504 hasAuthorship W3045644504A5017282697 @default.
- W3045644504 hasAuthorship W3045644504A5020971229 @default.
- W3045644504 hasAuthorship W3045644504A5054354024 @default.
- W3045644504 hasAuthorship W3045644504A5068544237 @default.
- W3045644504 hasConcept C121332964 @default.
- W3045644504 hasConcept C12554922 @default.
- W3045644504 hasConcept C133571119 @default.
- W3045644504 hasConcept C142724271 @default.
- W3045644504 hasConcept C14631669 @default.
- W3045644504 hasConcept C155672457 @default.
- W3045644504 hasConcept C156911925 @default.
- W3045644504 hasConcept C171250308 @default.
- W3045644504 hasConcept C178790620 @default.
- W3045644504 hasConcept C185592680 @default.
- W3045644504 hasConcept C192562407 @default.