FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045689520> ?p ?o ?g. }

• W3045689520 endingPage "100154" @default.
• W3045689520 startingPage "100154" @default.
• W3045689520 abstract "Iron reduction by venesection has been the cornerstone of treatment for haemochromatosis for decades, and its reported health benefits are many. Repeated phlebotomy can lead to a compensatory increase in intestinal iron absorption, reducing intestinal iron availability. Given that most gut bacteria are highly dependent on iron for survival, we postulated that, by reducing gut iron levels, venesection could alter the gut microbiota.Clinical parameters, faecal bacterial composition and metabolomes were assessed before and during treatment in a group of patients with haemochromatosis undergoing iron reduction therapy.Systemic iron reduction was associated with an alteration of the gut microbiome, with changes evident in those who experienced reduced faecal iron availability with venesection. For example, levels of Faecalibacterium prausnitzii, a bacterium associated with improved colonic health, were increased in response to faecal iron reduction. Similarly, metabolomic changes were seen in association with reduced faecal iron levels.These findings highlight a significant shift in the gut microbiome of patients who experience reduced colonic iron during venesection. Targeted depletion of faecal iron could represent a novel therapy for metabolic and inflammatory diseases, meriting further investigation.Iron depletion by repeated venesection is the mainstay of treatment for haemochromatosis, an iron-overload disorder. Venesection has been associated with several health benefits, including improvements in liver function tests, reversal of liver scarring, and reduced risk of liver cancer. During iron depletion, iron absorption from the gastrointestinal (GI) tract increases to compensate for iron lost with treatment. Iron availability is limited in the GI tract and is crucial to the growth and function of many gut bacteria. In this study we show that reduced iron availability in the colon following venesection treatment leads to a change in the composition of the gut bacteria, a finding that, to date, has not been studied in patients with haemochromatosis." @default.
• W3045689520 created "2020-08-03" @default.
• W3045689520 creator A5004405389 @default.
• W3045689520 creator A5010251635 @default.
• W3045689520 creator A5010873271 @default.
• W3045689520 creator A5018596617 @default.
• W3045689520 creator A5021823784 @default.
• W3045689520 creator A5024697101 @default.
• W3045689520 creator A5028777468 @default.
• W3045689520 creator A5033500678 @default.
• W3045689520 creator A5036184467 @default.
• W3045689520 creator A5038876648 @default.
• W3045689520 creator A5040135679 @default.
• W3045689520 creator A5064472428 @default.
• W3045689520 creator A5072838013 @default.
• W3045689520 creator A5079398943 @default.
• W3045689520 date "2020-12-01" @default.
• W3045689520 modified "2023-10-14" @default.
• W3045689520 title "Systemic iron reduction by venesection alters the gut microbiome in patients with haemochromatosis" @default.
• W3045689520 cites W1533060086 @default.
• W3045689520 cites W1979923361 @default.
• W3045689520 cites W2014723793 @default.
• W3045689520 cites W2035789303 @default.
• W3045689520 cites W2102851509 @default.
• W3045689520 cites W2110302416 @default.
• W3045689520 cites W2121093513 @default.
• W3045689520 cites W2126295648 @default.
• W3045689520 cites W2133856765 @default.
• W3045689520 cites W2138003397 @default.
• W3045689520 cites W2141125135 @default.
• W3045689520 cites W2156162308 @default.
• W3045689520 cites W2253470142 @default.
• W3045689520 cites W2592798109 @default.
• W3045689520 cites W2768560415 @default.
• W3045689520 cites W2885877348 @default.
• W3045689520 cites W2913462321 @default.
• W3045689520 cites W2942855392 @default.
• W3045689520 doi "https://doi.org/10.1016/j.jhepr.2020.100154" @default.
• W3045689520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7516344" @default.
• W3045689520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32995714" @default.
• W3045689520 hasPublicationYear "2020" @default.
• W3045689520 type Work @default.
• W3045689520 sameAs 3045689520 @default.
• W3045689520 citedByCount "5" @default.
• W3045689520 countsByYear W30456895202020 @default.
• W3045689520 countsByYear W30456895202022 @default.
• W3045689520 countsByYear W30456895202023 @default.
• W3045689520 crossrefType "journal-article" @default.
• W3045689520 hasAuthorship W3045689520A5004405389 @default.
• W3045689520 hasAuthorship W3045689520A5010251635 @default.
• W3045689520 hasAuthorship W3045689520A5010873271 @default.
• W3045689520 hasAuthorship W3045689520A5018596617 @default.
• W3045689520 hasAuthorship W3045689520A5021823784 @default.
• W3045689520 hasAuthorship W3045689520A5024697101 @default.
• W3045689520 hasAuthorship W3045689520A5028777468 @default.
• W3045689520 hasAuthorship W3045689520A5033500678 @default.
• W3045689520 hasAuthorship W3045689520A5036184467 @default.
• W3045689520 hasAuthorship W3045689520A5038876648 @default.
• W3045689520 hasAuthorship W3045689520A5040135679 @default.
• W3045689520 hasAuthorship W3045689520A5064472428 @default.
• W3045689520 hasAuthorship W3045689520A5072838013 @default.
• W3045689520 hasAuthorship W3045689520A5079398943 @default.
• W3045689520 hasBestOaLocation W30456895201 @default.
• W3045689520 hasConcept C126322002 @default.
• W3045689520 hasConcept C143121216 @default.
• W3045689520 hasConcept C203014093 @default.
• W3045689520 hasConcept C2776590208 @default.
• W3045689520 hasConcept C2776672577 @default.
• W3045689520 hasConcept C2777357209 @default.
• W3045689520 hasConcept C2777417653 @default.
• W3045689520 hasConcept C2778248108 @default.
• W3045689520 hasConcept C2780512811 @default.
• W3045689520 hasConcept C2780675110 @default.
• W3045689520 hasConcept C2992479659 @default.
• W3045689520 hasConcept C3017702006 @default.
• W3045689520 hasConcept C3019978661 @default.
• W3045689520 hasConcept C42407357 @default.
• W3045689520 hasConcept C539455810 @default.
• W3045689520 hasConcept C60644358 @default.
• W3045689520 hasConcept C71924100 @default.
• W3045689520 hasConcept C86803240 @default.
• W3045689520 hasConcept C90924648 @default.
• W3045689520 hasConceptScore W3045689520C126322002 @default.
• W3045689520 hasConceptScore W3045689520C143121216 @default.
• W3045689520 hasConceptScore W3045689520C203014093 @default.
• W3045689520 hasConceptScore W3045689520C2776590208 @default.
• W3045689520 hasConceptScore W3045689520C2776672577 @default.
• W3045689520 hasConceptScore W3045689520C2777357209 @default.
• W3045689520 hasConceptScore W3045689520C2777417653 @default.
• W3045689520 hasConceptScore W3045689520C2778248108 @default.
• W3045689520 hasConceptScore W3045689520C2780512811 @default.
• W3045689520 hasConceptScore W3045689520C2780675110 @default.
• W3045689520 hasConceptScore W3045689520C2992479659 @default.
• W3045689520 hasConceptScore W3045689520C3017702006 @default.
• W3045689520 hasConceptScore W3045689520C3019978661 @default.
• W3045689520 hasConceptScore W3045689520C42407357 @default.
• W3045689520 hasConceptScore W3045689520C539455810 @default.
• W3045689520 hasConceptScore W3045689520C60644358 @default.

• next