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- W3045708843 abstract "Abstract Cholesterol is a structural component of cellular membranes particularly enriched in synapses but its role in synaptic transmission remains poorly understood. We used rat hippocampal cultures and their acute cholesterol depletion by methyl-β-cyclodextrin as a tool to describe the physiological role of cholesterol in glutamatergic synaptic transmission. Cholesterol proved to be a key molecule for the function of synapses as its depletion resulted in a significant reduction of both NMDA receptor (NMDAR) and AMPA/kainate receptor-mediated evoked excitatory postsynaptic currents (eEPSCs), by 94% and 72%, respectively. We identified two presynaptic and two postsynaptic steps of synaptic transmission which are modulated by cholesterol and explain together the above-mentioned reduction of eEPSCs. In the postsynapse, we show that physiological levels of cholesterol are important for maintaining the normal probability of opening of NMDARs and for keeping NMDARs localized in synapses. In the presynapse, our results favour the hypothesis of a role of cholesterol in the propagation of axonal action potentials. Finally, cholesterol is a negative modulator of spontaneous presynaptic glutamate release. Our study identifies cholesterol as an important endogenous regulator of synaptic transmission and provides insight into molecular mechanisms underlying the neurological manifestation of diseases associated with impaired cholesterol synthesis or decomposition." @default.
- W3045708843 created "2020-08-03" @default.
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- W3045708843 date "2020-07-28" @default.
- W3045708843 modified "2023-10-01" @default.
- W3045708843 title "Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission" @default.
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- W3045708843 cites W1971899172 @default.
- W3045708843 cites W1978120234 @default.
- W3045708843 cites W1980059018 @default.
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- W3045708843 cites W1992465104 @default.
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- W3045708843 cites W1998718798 @default.
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- W3045708843 cites W2003674836 @default.
- W3045708843 cites W2005215395 @default.
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- W3045708843 cites W2037852973 @default.
- W3045708843 cites W2041796198 @default.
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- W3045708843 cites W2529052661 @default.
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- W3045708843 doi "https://doi.org/10.1038/s41598-020-69454-5" @default.
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- W3045708843 hasPublicationYear "2020" @default.
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