FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045732533> ?p ?o ?g. }

• W3045732533 endingPage "102940" @default.
• W3045732533 startingPage "102940" @default.
• W3045732533 abstract "• At low dose (15 μM HPTA) it has the same anti-cancer effects as 500 μM Valproic acid. • HPTA can sensitize breast tumor cells to HU by augmenting HU-induced DNA DSBs. • HPTA can inhibit RPA2-p mediated Rad51 dependent HR pathway after HU-induced DNA replication arrest. Breast carcinoma is one of the most common malignancies in women. Previous studies have reported that 500 μM valproic acid can sensitize breast tumor cells to the anti-neoplastic agent hydroxyurea. However, the dose requirements for valproic acid is highly variable due to the wide inter-individuals clinical characteristics. High therapeutic dose of valproic acid required to induce anti-tumor activity in solid tumor was associated with increased adverse effects. There are attempts to locate suitably high-efficient low-toxicity valproic acid derivatives. We demonstrated that lower dose of 2-hexyl-4-pentynoic acid (HPTA; 15 μM) has similar effects as 500 μM VPA in inhibiting breast cancer cell growth and sensitizing the tumor cells to hydroxyurea on MCF7 cells, EUFA423 cells, MCF7 cells with defective RPA2-p gene and primary culture cells derived from tissue-transformed breast tumor cells. We discovered HPTA resulted in more DNA double-strand breaks, the homologous recombination was inhibited through the interference of the hyperphosphorylation of replication protein A2 and recombinase Rad51. Our data postulate that HPTA may be a potential novel sensitizer to hydroxyurea in the treatment of breast carcinoma." @default.
• W3045732533 created "2020-08-03" @default.
• W3045732533 creator A5012182290 @default.
• W3045732533 creator A5054763410 @default.
• W3045732533 creator A5063197689 @default.
• W3045732533 creator A5068076124 @default.
• W3045732533 creator A5078464879 @default.
• W3045732533 creator A5083583828 @default.
• W3045732533 creator A5090541429 @default.
• W3045732533 date "2020-11-01" @default.
• W3045732533 modified "2023-10-06" @default.
• W3045732533 title "2-hexyl-4-pentynoic acid, a potential therapeutic for breast carcinoma by influencing RPA2 hyperphosphorylation-mediated DNA repair" @default.
• W3045732533 cites W1029697775 @default.
• W3045732533 cites W1271389891 @default.
• W3045732533 cites W1487070667 @default.
• W3045732533 cites W1963821783 @default.
• W3045732533 cites W1967931372 @default.
• W3045732533 cites W1980947442 @default.
• W3045732533 cites W1999090017 @default.
• W3045732533 cites W2009096065 @default.
• W3045732533 cites W2013419634 @default.
• W3045732533 cites W2015946135 @default.
• W3045732533 cites W2044364806 @default.
• W3045732533 cites W2050165918 @default.
• W3045732533 cites W2054654390 @default.
• W3045732533 cites W2062739292 @default.
• W3045732533 cites W2063532739 @default.
• W3045732533 cites W2071411482 @default.
• W3045732533 cites W2072806146 @default.
• W3045732533 cites W2073109135 @default.
• W3045732533 cites W2081364359 @default.
• W3045732533 cites W2101161126 @default.
• W3045732533 cites W2104885432 @default.
• W3045732533 cites W2129069151 @default.
• W3045732533 cites W2163462721 @default.
• W3045732533 cites W2163515135 @default.
• W3045732533 cites W2163784659 @default.
• W3045732533 cites W2259074466 @default.
• W3045732533 cites W2281078751 @default.
• W3045732533 cites W2285115828 @default.
• W3045732533 cites W2313541759 @default.
• W3045732533 cites W2612620305 @default.
• W3045732533 cites W2745231876 @default.
• W3045732533 cites W2795208162 @default.
• W3045732533 cites W2885720458 @default.
• W3045732533 cites W2965942084 @default.
• W3045732533 doi "https://doi.org/10.1016/j.dnarep.2020.102940" @default.
• W3045732533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32795962" @default.
• W3045732533 hasPublicationYear "2020" @default.
• W3045732533 type Work @default.
• W3045732533 sameAs 3045732533 @default.
• W3045732533 citedByCount "7" @default.
• W3045732533 countsByYear W30457325332021 @default.
• W3045732533 countsByYear W30457325332022 @default.
• W3045732533 countsByYear W30457325332023 @default.
• W3045732533 crossrefType "journal-article" @default.
• W3045732533 hasAuthorship W3045732533A5012182290 @default.
• W3045732533 hasAuthorship W3045732533A5054763410 @default.
• W3045732533 hasAuthorship W3045732533A5063197689 @default.
• W3045732533 hasAuthorship W3045732533A5068076124 @default.
• W3045732533 hasAuthorship W3045732533A5078464879 @default.
• W3045732533 hasAuthorship W3045732533A5083583828 @default.
• W3045732533 hasAuthorship W3045732533A5090541429 @default.
• W3045732533 hasConcept C11960822 @default.
• W3045732533 hasConcept C121608353 @default.
• W3045732533 hasConcept C134935766 @default.
• W3045732533 hasConcept C2778198054 @default.
• W3045732533 hasConcept C3018521938 @default.
• W3045732533 hasConcept C502942594 @default.
• W3045732533 hasConcept C530470458 @default.
• W3045732533 hasConcept C54355233 @default.
• W3045732533 hasConcept C552990157 @default.
• W3045732533 hasConcept C86803240 @default.
• W3045732533 hasConceptScore W3045732533C11960822 @default.
• W3045732533 hasConceptScore W3045732533C121608353 @default.
• W3045732533 hasConceptScore W3045732533C134935766 @default.
• W3045732533 hasConceptScore W3045732533C2778198054 @default.
• W3045732533 hasConceptScore W3045732533C3018521938 @default.
• W3045732533 hasConceptScore W3045732533C502942594 @default.
• W3045732533 hasConceptScore W3045732533C530470458 @default.
• W3045732533 hasConceptScore W3045732533C54355233 @default.
• W3045732533 hasConceptScore W3045732533C552990157 @default.
• W3045732533 hasConceptScore W3045732533C86803240 @default.
• W3045732533 hasFunder F4320321001 @default.
• W3045732533 hasLocation W30457325331 @default.
• W3045732533 hasOpenAccess W3045732533 @default.
• W3045732533 hasPrimaryLocation W30457325331 @default.
• W3045732533 hasRelatedWork W1527047098 @default.
• W3045732533 hasRelatedWork W2006648163 @default.
• W3045732533 hasRelatedWork W2104391914 @default.
• W3045732533 hasRelatedWork W2166346463 @default.
• W3045732533 hasRelatedWork W2349405660 @default.
• W3045732533 hasRelatedWork W2419396135 @default.
• W3045732533 hasRelatedWork W2996380602 @default.
• W3045732533 hasRelatedWork W3139841161 @default.
• W3045732533 hasRelatedWork W4234565041 @default.
• W3045732533 hasRelatedWork W3141738669 @default.
• W3045732533 hasVolume "95" @default.

• next