FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045743418> ?p ?o ?g. }

• W3045743418 abstract "A wide range of duration of viral RNA shedding in patients infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been observed. We aimed to investigate factors associated with prolonged and intermittent viral RNA shedding in a retrospective cohort of symptomatic COVID-19 patients.Demographic, clinical and laboratory data from hospitalised COVID-19 patients from a single centre with two consecutive negative respiratory reverse transcription-polymerase chain reaction (RT-PCR) results were extracted from electronic medical records. Kaplan-Meier survival curve analysis was used to assess the effect of clinical characteristics on the duration and pattern of shedding. Plasma levels of immune mediators were measured using Luminex multiplex microbead-based immunoassay.There were 201 symptomatic patients included. Median age was 49 years (interquartile range 16-61), and 52.2% were male. Median RNA shedding was 14 days (IQR 9-18). Intermittent shedding was observed in 77 (38.3%). We did not identify any factor associated with prolonged or intermittent viral RNA shedding. Duration of shedding was inversely correlated with plasma levels of T-cell cytokines IL-1β and IL-17A at the initial phase of infection, and patients had lower levels of pro-inflammatory cytokines during intermittent shedding.Less active T-cell responses at the initial phase of infection were associated with prolonged viral RNA shedding, suggesting that early immune responses are beneficial to control viral load and prevent viral RNA shedding. Intermittent shedding is common and may explain re-detection of viral RNA in recovered patients." @default.
• W3045743418 created "2020-08-03" @default.
• W3045743418 creator A5005551249 @default.
• W3045743418 creator A5005793081 @default.
• W3045743418 creator A5013366445 @default.
• W3045743418 creator A5015431342 @default.
• W3045743418 creator A5016545803 @default.
• W3045743418 creator A5031060060 @default.
• W3045743418 creator A5039929987 @default.
• W3045743418 creator A5040602022 @default.
• W3045743418 creator A5043827008 @default.
• W3045743418 creator A5051752076 @default.
• W3045743418 creator A5056329233 @default.
• W3045743418 creator A5066074596 @default.
• W3045743418 creator A5072298339 @default.
• W3045743418 creator A5073669446 @default.
• W3045743418 creator A5090930211 @default.
• W3045743418 date "2020-01-01" @default.
• W3045743418 modified "2023-10-16" @default.
• W3045743418 title "Associations of viral ribonucleic acid (RNA) shedding patterns with clinical illness and immune responses in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) infection" @default.
• W3045743418 cites W1495994055 @default.
• W3045743418 cites W1565157642 @default.
• W3045743418 cites W1995121548 @default.
• W3045743418 cites W2045538827 @default.
• W3045743418 cites W2103387430 @default.
• W3045743418 cites W2103681608 @default.
• W3045743418 cites W2115101593 @default.
• W3045743418 cites W2127268294 @default.
• W3045743418 cites W2129542667 @default.
• W3045743418 cites W2158549296 @default.
• W3045743418 cites W2469586991 @default.
• W3045743418 cites W2525468044 @default.
• W3045743418 cites W2535407918 @default.
• W3045743418 cites W2769689735 @default.
• W3045743418 cites W2805703779 @default.
• W3045743418 cites W3008116551 @default.
• W3045743418 cites W3008827533 @default.
• W3045743418 cites W3009885589 @default.
• W3045743418 cites W3012610905 @default.
• W3045743418 cites W3013893137 @default.
• W3045743418 cites W3013985547 @default.
• W3045743418 cites W3015931063 @default.
• W3045743418 cites W3016266726 @default.
• W3045743418 cites W3017258809 @default.
• W3045743418 cites W3024220416 @default.
• W3045743418 doi "https://doi.org/10.1002/cti2.1160" @default.
• W3045743418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7385430" @default.
• W3045743418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32742654" @default.
• W3045743418 hasPublicationYear "2020" @default.
• W3045743418 type Work @default.
• W3045743418 sameAs 3045743418 @default.
• W3045743418 citedByCount "27" @default.
• W3045743418 countsByYear W30457434182020 @default.
• W3045743418 countsByYear W30457434182021 @default.
• W3045743418 countsByYear W30457434182022 @default.
• W3045743418 countsByYear W30457434182023 @default.
• W3045743418 crossrefType "journal-article" @default.
• W3045743418 hasAuthorship W3045743418A5005551249 @default.
• W3045743418 hasAuthorship W3045743418A5005793081 @default.
• W3045743418 hasAuthorship W3045743418A5013366445 @default.
• W3045743418 hasAuthorship W3045743418A5015431342 @default.
• W3045743418 hasAuthorship W3045743418A5016545803 @default.
• W3045743418 hasAuthorship W3045743418A5031060060 @default.
• W3045743418 hasAuthorship W3045743418A5039929987 @default.
• W3045743418 hasAuthorship W3045743418A5040602022 @default.
• W3045743418 hasAuthorship W3045743418A5043827008 @default.
• W3045743418 hasAuthorship W3045743418A5051752076 @default.
• W3045743418 hasAuthorship W3045743418A5056329233 @default.
• W3045743418 hasAuthorship W3045743418A5066074596 @default.
• W3045743418 hasAuthorship W3045743418A5072298339 @default.
• W3045743418 hasAuthorship W3045743418A5073669446 @default.
• W3045743418 hasAuthorship W3045743418A5090930211 @default.
• W3045743418 hasBestOaLocation W30457434181 @default.
• W3045743418 hasConcept C104317684 @default.
• W3045743418 hasConcept C119060515 @default.
• W3045743418 hasConcept C126322002 @default.
• W3045743418 hasConcept C12914427 @default.
• W3045743418 hasConcept C142462285 @default.
• W3045743418 hasConcept C159047783 @default.
• W3045743418 hasConcept C203014093 @default.
• W3045743418 hasConcept C2522874641 @default.
• W3045743418 hasConcept C2777648638 @default.
• W3045743418 hasConcept C2779134260 @default.
• W3045743418 hasConcept C3008058167 @default.
• W3045743418 hasConcept C524204448 @default.
• W3045743418 hasConcept C55493867 @default.
• W3045743418 hasConcept C67705224 @default.
• W3045743418 hasConcept C71924100 @default.
• W3045743418 hasConcept C86803240 @default.
• W3045743418 hasConcept C8891405 @default.
• W3045743418 hasConceptScore W3045743418C104317684 @default.
• W3045743418 hasConceptScore W3045743418C119060515 @default.
• W3045743418 hasConceptScore W3045743418C126322002 @default.
• W3045743418 hasConceptScore W3045743418C12914427 @default.
• W3045743418 hasConceptScore W3045743418C142462285 @default.
• W3045743418 hasConceptScore W3045743418C159047783 @default.
• W3045743418 hasConceptScore W3045743418C203014093 @default.
• W3045743418 hasConceptScore W3045743418C2522874641 @default.
• W3045743418 hasConceptScore W3045743418C2777648638 @default.
• W3045743418 hasConceptScore W3045743418C2779134260 @default.

• next