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- W3045753208 abstract "BACKGROUND: Evidence on the impact of tuberculosis (TB) treatment on lung function is scarce. The aim of this study was to evaluate post-treatment sequelae in drug-susceptible and drug-resistant-TB (DR-TB) cases in Mexico and Italy. METHODS: At the end of TB treatment the patients underwent complete clinical assessment, functional evaluation of respiratory mechanics, gas exchange and a 6-minute walking test. Treatment regimens (and definitions) recommended by the World Health Organization were used throughout. RESULTS: Of 61 patients, 65.6% had functional impairment, with obstruction in 24/61 patients (39.4%), and 78% with no bronchodilator response. These effects were more prevalent among DR-TB cases (forced expiratory volume in 1 s/forced vital capacity [FEV 1 /FVC] < lower limit of normality, 14/24 vs. 10/34; P = 0.075). DR-TB patients showed moderately severe (FEV 1 < 60%) and severe obstruction (FEV 1 < 50%) ( P = 0.008). Pre- and post-bronchodilator FEV 1 and FEV 1 /FVC (% of predicted) were significantly lower among DR-TB cases. Plethysmography abnormalities (restriction, hyperinflation and/or air trapping) were more frequent among DR-TB cases ( P = 0.001), along with abnormal carbon monoxide diffusing capacity (DLCO) ( P = 0.003). CONCLUSION: The majority of TB patients suffer the consequences of post-treatment sequelae (of differing levels), which compromise quality of life, exercise tolerance and long-term prognosis. It is therefore important that lung function is comprehensively evaluated post-treatment to identify patient needs for future medication and pulmonary rehabilitation." @default.
- W3045753208 created "2020-08-03" @default.
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- W3045753208 date "2020-07-01" @default.
- W3045753208 modified "2023-10-18" @default.
- W3045753208 title "Functional impact of sequelae in drug-susceptible and multidrug-resistant tuberculosis" @default.
- W3045753208 doi "https://doi.org/10.5588/ijtld.19.0809" @default.
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