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• W3045762267 startingPage "81" @default.
• W3045762267 abstract "Interlamellar bonding in the arterial wall is often compromised by cardiovascular diseases. However, several recent nationwide and hospital-based studies have uniformly reported reduced risk of thoracic aortic dissection in patients with diabetes. As one of the primary structural constituents in the arterial wall, elastin plays an important role in providing its interlamellar structural integrity. The purpose of this study is to examine the effects of glycation on the interlamellar bonding properties of arterial elastin. Purified elastin network was isolated from porcine descending thoracic aorta and incubated in 2 M glucose solution for 7, 14 or 21 days at 37 °C. Peeling and direct tension tests were performed to provide complimentary information on understanding the interlamellar layer separation properties of elastin network with glycation effect. Peeling tests were simulated using a cohesive zone model (CZM). Multiphoton imaging was used to visualize the interlamellar elastin fibers in samples subjected to peeling and direct tension. Peeling and direct tension tests show that interlamellar energy release rate and strength both increase with the duration of glucose treatment. The traction at damage initiation estimated for the CZM agrees well with the interlamellar strength measurements from direct tension tests. Glycation was also found to increase the interlamellar failure strain of arterial elastin. Multiphoton imaging confirmed the contribution of radially running elastin fibers to resisting dissection. Nonenzymatic glycation reduces the propensity of arterial elastin to dissection. This study also suggests that the CZM effectively describes the interlamellar bonding properties of arterial elastin." @default.
• W3045762267 created "2020-08-03" @default.
• W3045762267 creator A5028345995 @default.
• W3045762267 creator A5028579207 @default.
• W3045762267 creator A5066296813 @default.
• W3045762267 creator A5081062868 @default.
• W3045762267 date "2020-07-29" @default.
• W3045762267 modified "2023-10-16" @default.
• W3045762267 title "Effect of Glycation on Interlamellar Bonding of Arterial Elastin" @default.
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• W3045762267 doi "https://doi.org/10.1007/s11340-020-00644-y" @default.
• W3045762267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7880226" @default.
• W3045762267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33583947" @default.
• W3045762267 hasPublicationYear "2020" @default.
• W3045762267 type Work @default.
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• W3045762267 citedByCount "8" @default.

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