Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045768082> ?p ?o ?g. }
- W3045768082 abstract "Abstract Heart failure is a leading cause of death that develops subsequent to deleterious hypertrophic cardiac remodelling. MAPK pathways play a key role in coordinating the induction of gene expression during hypertrophy. Induction of the immediate early gene (IEG) response is a necessary and early event in this process. How MAPK and IEG expression are coupled during cardiac hypertrophy is not yet resolved. Here, in vitro, in rodent models and in human samples, we demonstrate that MAPK-stimulated IEG induction depends on the Mitogen and Stress activated protein Kinase (MSK) and its phosphorylation of histone H3 at serine 28 (pH3S28). pH3S28 in IEG promoters in turn recruits Brg1, a BAF60 ATP-dependent chromatin remodelling complex component, initiating gene expression. Without MSK activity and IEG induction, the hypertrophic response is suppressed. These studies provide new mechanistic insights and highlight the role of signalling to the epigenome in gene expression regulation during cardiac hypertrophy. Brief summary one sentence MSK1/2 phosphorylation of Histone 3 Serine 28 couples MAPK signalling with chromatin remodelling and immediate early gene expression to induce pro-hypertrophic cardiac transcriptional responses." @default.
- W3045768082 created "2020-08-03" @default.
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- W3045768082 date "2020-07-29" @default.
- W3045768082 modified "2023-10-16" @default.
- W3045768082 title "MSK-mediated phosphorylation of Histone 3 Ser28 couples MAPK signaling with early gene induction and cardiac hypertrophy" @default.
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- W3045768082 cites W1635552303 @default.
- W3045768082 cites W1806414990 @default.
- W3045768082 cites W1813955311 @default.
- W3045768082 cites W1847275787 @default.
- W3045768082 cites W1968461085 @default.
- W3045768082 cites W1975043059 @default.
- W3045768082 cites W1976327414 @default.
- W3045768082 cites W1978314382 @default.
- W3045768082 cites W1978821056 @default.
- W3045768082 cites W1979802232 @default.
- W3045768082 cites W1999157780 @default.
- W3045768082 cites W2001367960 @default.
- W3045768082 cites W2006224306 @default.
- W3045768082 cites W2009229814 @default.
- W3045768082 cites W2010534999 @default.
- W3045768082 cites W2012051875 @default.
- W3045768082 cites W2016774526 @default.
- W3045768082 cites W2019571270 @default.
- W3045768082 cites W2020904834 @default.
- W3045768082 cites W2023452597 @default.
- W3045768082 cites W2025018429 @default.
- W3045768082 cites W2027425960 @default.
- W3045768082 cites W2028761750 @default.
- W3045768082 cites W2036224418 @default.
- W3045768082 cites W2036272929 @default.
- W3045768082 cites W2042439588 @default.
- W3045768082 cites W2046822015 @default.
- W3045768082 cites W2049122589 @default.
- W3045768082 cites W2050014799 @default.
- W3045768082 cites W2053383702 @default.
- W3045768082 cites W2056633265 @default.
- W3045768082 cites W2057226991 @default.
- W3045768082 cites W2057786779 @default.
- W3045768082 cites W2058744360 @default.
- W3045768082 cites W2067507708 @default.
- W3045768082 cites W2071094609 @default.
- W3045768082 cites W2071276062 @default.
- W3045768082 cites W2072319964 @default.
- W3045768082 cites W2072891811 @default.
- W3045768082 cites W2079003535 @default.
- W3045768082 cites W2083624932 @default.
- W3045768082 cites W2084429276 @default.
- W3045768082 cites W2094580473 @default.
- W3045768082 cites W2096847688 @default.
- W3045768082 cites W2100712519 @default.
- W3045768082 cites W2102452201 @default.
- W3045768082 cites W2104640964 @default.
- W3045768082 cites W2105802609 @default.
- W3045768082 cites W2106971217 @default.
- W3045768082 cites W2107195951 @default.
- W3045768082 cites W2107277218 @default.
- W3045768082 cites W2113111385 @default.
- W3045768082 cites W2116932184 @default.
- W3045768082 cites W2120334619 @default.
- W3045768082 cites W2126242473 @default.
- W3045768082 cites W2131162745 @default.
- W3045768082 cites W2139543479 @default.
- W3045768082 cites W2144099695 @default.
- W3045768082 cites W2147784061 @default.
- W3045768082 cites W2155591792 @default.
- W3045768082 cites W2156067423 @default.
- W3045768082 cites W2161579926 @default.
- W3045768082 cites W2162772930 @default.
- W3045768082 cites W2165207985 @default.
- W3045768082 cites W2320926313 @default.
- W3045768082 cites W2394623751 @default.
- W3045768082 cites W2552191926 @default.
- W3045768082 cites W2607257758 @default.
- W3045768082 cites W2610602137 @default.
- W3045768082 cites W2796884782 @default.
- W3045768082 cites W2889986213 @default.
- W3045768082 cites W2980401370 @default.
- W3045768082 doi "https://doi.org/10.1101/2020.07.28.224832" @default.
- W3045768082 hasPublicationYear "2020" @default.
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