Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045776823> ?p ?o ?g. }
- W3045776823 endingPage "1697" @default.
- W3045776823 startingPage "1687" @default.
- W3045776823 abstract "Objective Uncoupling protein 3 (UCP3) is a mitochondrial carrier related to fatty acid metabolism. Although gene variants of UCP3 are associated with human obesity, their contribution to increased adiposity remains unclear. This study investigated the impact that loss of UCP3 has on diet‐induced obesity in rats. Methods Male UCP3 knockout rats (ucp3 −/− ) and wild‐type littermates (ucp3 +/+ ) were fed a high‐fat, high‐carbohydrate Western diet for 21 weeks. Body composition was analyzed by EchoMRI. Whole‐body insulin sensitivity and rates of tissue glucose uptake were determined by using hyperinsulinemic‐euglycemic clamp. Changes in tissue physiology were interrogated by microscopy and RNA sequencing. Results Loss of UCP3 decreased fat mass gain, white adipocytes size, and systemic inflammation. The ucp3 −/− rats also exhibited preserved insulin sensitivity and increased glucose uptake in interscapular brown adipose tissue (iBAT). Brown adipocytes from ucp3 −/− rats were protected from cellular degeneration caused by lipid accumulation and from reactive oxygen species–induced protein sulfonation. Increased glutathione levels in iBAT from ucp3 −/− rats were linked to upregulation of genes encoding enzymes from the transsulfuration pathway in that tissue. Conclusions Loss of UCP3 partially protects rats from diet‐induced obesity. This phenotype is related to induction of a compensatory antioxidant mechanism and prevention of iBAT whitening. image" @default.
- W3045776823 created "2020-08-03" @default.
- W3045776823 creator A5007535805 @default.
- W3045776823 creator A5027926207 @default.
- W3045776823 creator A5042873739 @default.
- W3045776823 creator A5070647549 @default.
- W3045776823 date "2020-07-27" @default.
- W3045776823 modified "2023-10-16" @default.
- W3045776823 title "Loss of Uncoupling Protein 3 Attenuates Western Diet–Induced Obesity, Systemic Inflammation, and Insulin Resistance in Rats" @default.
- W3045776823 cites W1838484704 @default.
- W3045776823 cites W1965079305 @default.
- W3045776823 cites W2006353250 @default.
- W3045776823 cites W2013891116 @default.
- W3045776823 cites W2040328785 @default.
- W3045776823 cites W2051993213 @default.
- W3045776823 cites W2055549410 @default.
- W3045776823 cites W2057683888 @default.
- W3045776823 cites W2060068456 @default.
- W3045776823 cites W2077427479 @default.
- W3045776823 cites W2079458541 @default.
- W3045776823 cites W2079482653 @default.
- W3045776823 cites W2086501334 @default.
- W3045776823 cites W2115589168 @default.
- W3045776823 cites W2116692231 @default.
- W3045776823 cites W2119649463 @default.
- W3045776823 cites W2123667875 @default.
- W3045776823 cites W2136070507 @default.
- W3045776823 cites W2136747158 @default.
- W3045776823 cites W2141458291 @default.
- W3045776823 cites W2151665669 @default.
- W3045776823 cites W2157235709 @default.
- W3045776823 cites W2159844679 @default.
- W3045776823 cites W2162707945 @default.
- W3045776823 cites W2176307085 @default.
- W3045776823 cites W2332777704 @default.
- W3045776823 cites W2418449153 @default.
- W3045776823 cites W2518904228 @default.
- W3045776823 cites W2609075277 @default.
- W3045776823 cites W2610578090 @default.
- W3045776823 cites W2768973912 @default.
- W3045776823 cites W2794090131 @default.
- W3045776823 cites W2795070658 @default.
- W3045776823 cites W2805376596 @default.
- W3045776823 cites W2805446818 @default.
- W3045776823 cites W2898617826 @default.
- W3045776823 cites W2913067888 @default.
- W3045776823 cites W2939342250 @default.
- W3045776823 cites W2942943982 @default.
- W3045776823 cites W2950070140 @default.
- W3045776823 cites W3005514510 @default.
- W3045776823 cites W78657649 @default.
- W3045776823 doi "https://doi.org/10.1002/oby.22879" @default.
- W3045776823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7483834" @default.
- W3045776823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32716607" @default.
- W3045776823 hasPublicationYear "2020" @default.
- W3045776823 type Work @default.
- W3045776823 sameAs 3045776823 @default.
- W3045776823 citedByCount "4" @default.
- W3045776823 countsByYear W30457768232021 @default.
- W3045776823 countsByYear W30457768232023 @default.
- W3045776823 crossrefType "journal-article" @default.
- W3045776823 hasAuthorship W3045776823A5007535805 @default.
- W3045776823 hasAuthorship W3045776823A5027926207 @default.
- W3045776823 hasAuthorship W3045776823A5042873739 @default.
- W3045776823 hasAuthorship W3045776823A5070647549 @default.
- W3045776823 hasBestOaLocation W30457768232 @default.
- W3045776823 hasConcept C126322002 @default.
- W3045776823 hasConcept C134018914 @default.
- W3045776823 hasConcept C151955695 @default.
- W3045776823 hasConcept C17093226 @default.
- W3045776823 hasConcept C171089720 @default.
- W3045776823 hasConcept C185592680 @default.
- W3045776823 hasConcept C2777391703 @default.
- W3045776823 hasConcept C2779299233 @default.
- W3045776823 hasConcept C2779306644 @default.
- W3045776823 hasConcept C2779406938 @default.
- W3045776823 hasConcept C2780642333 @default.
- W3045776823 hasConcept C511355011 @default.
- W3045776823 hasConcept C544821477 @default.
- W3045776823 hasConcept C71924100 @default.
- W3045776823 hasConcept C86803240 @default.
- W3045776823 hasConceptScore W3045776823C126322002 @default.
- W3045776823 hasConceptScore W3045776823C134018914 @default.
- W3045776823 hasConceptScore W3045776823C151955695 @default.
- W3045776823 hasConceptScore W3045776823C17093226 @default.
- W3045776823 hasConceptScore W3045776823C171089720 @default.
- W3045776823 hasConceptScore W3045776823C185592680 @default.
- W3045776823 hasConceptScore W3045776823C2777391703 @default.
- W3045776823 hasConceptScore W3045776823C2779299233 @default.
- W3045776823 hasConceptScore W3045776823C2779306644 @default.
- W3045776823 hasConceptScore W3045776823C2779406938 @default.
- W3045776823 hasConceptScore W3045776823C2780642333 @default.
- W3045776823 hasConceptScore W3045776823C511355011 @default.
- W3045776823 hasConceptScore W3045776823C544821477 @default.
- W3045776823 hasConceptScore W3045776823C71924100 @default.
- W3045776823 hasConceptScore W3045776823C86803240 @default.
- W3045776823 hasFunder F4320337338 @default.
- W3045776823 hasFunder F4320337354 @default.