FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045806320> ?p ?o ?g. }

• W3045806320 endingPage "361" @default.
• W3045806320 startingPage "347" @default.
• W3045806320 abstract "In 2019, lung cancer was estimated to be the leading cause of cancer deaths in humans. Polycyclic aromatic hydrocarbons (PAHs) are known to increase the risk of lung cancer. PAHs are metabolized by the cytochrome P450 (CYP)1A subfamily, comprised of the CYP1A1 and 1A2 monooxygenases. These enzymes bioactivate PAHs into reactive metabolites that induce mutagenic DNA adducts, which can lead to cancer. Past studies have investigated the role of CYP1A1 in PAH bioactivation; however, the individual roles of each CYP1A enzyme are still unknown. In this investigation, we tested the hypothesis that mice lacking the genes for Cyp1a1 or Cyp1a2 will display altered susceptibilities to PAH-induced pulmonary carcinogenesis. Wild-type, Cyp1a1-null (Cyp1a1-/-), and Cyp1a2-null (Cyp1a2-/-) male and female mice were treated with 3-methylcholanthrene for cancer initiation and tumor formation studies. In wild-type mice, CYP1A1 and 1A2 expression was induced by 3-methylcholanthrene. Cyp1a1-/- and Cyp1a2-/- mice treated with PAHs displayed a compensatory pattern, where knocking out 1 Cyp1a gene led to increased expression of the other. Cyp1a1-/- mice were resistant to DNA adduct and tumor formation, whereas Cyp1a2-/- mice displayed increased levels of both. UALCAN analysis revealed that lung adenocarcinoma patients with high levels of CYP1A2 expression survive significantly better than patients with low/medium expression. In conclusion, Cyp1a1-/- mice were less susceptible to PAH-induced pulmonary carcinogenesis, whereas Cyp1a2-/- mice were more susceptible. In addition, high CYP1A2 expression was found to be protective for lung adenocarcinoma patients. These results support the need to develop novel CYP1A1 inhibitors to mitigate human lung cancer." @default.
• W3045806320 created "2020-08-03" @default.
• W3045806320 creator A5001364718 @default.
• W3045806320 creator A5010768908 @default.
• W3045806320 creator A5018499913 @default.
• W3045806320 creator A5040215906 @default.
• W3045806320 creator A5058280342 @default.
• W3045806320 creator A5063079542 @default.
• W3045806320 creator A5073980001 @default.
• W3045806320 date "2020-07-29" @default.
• W3045806320 modified "2023-10-16" @default.
• W3045806320 title "Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A2-Null Mice: Roles of CYP1A1 and CYP1A2" @default.
• W3045806320 cites W1548174106 @default.
• W3045806320 cites W1958513894 @default.
• W3045806320 cites W1964109666 @default.
• W3045806320 cites W1966816922 @default.
• W3045806320 cites W1997828131 @default.
• W3045806320 cites W2000012794 @default.
• W3045806320 cites W2001136263 @default.
• W3045806320 cites W2007684837 @default.
• W3045806320 cites W2030005694 @default.
• W3045806320 cites W2035062238 @default.
• W3045806320 cites W2042972092 @default.
• W3045806320 cites W2062909384 @default.
• W3045806320 cites W2063434099 @default.
• W3045806320 cites W2075649289 @default.
• W3045806320 cites W2078938105 @default.
• W3045806320 cites W2079612457 @default.
• W3045806320 cites W2081244152 @default.
• W3045806320 cites W2083832226 @default.
• W3045806320 cites W2089272059 @default.
• W3045806320 cites W2095705456 @default.
• W3045806320 cites W2108728760 @default.
• W3045806320 cites W2115987919 @default.
• W3045806320 cites W2127001802 @default.
• W3045806320 cites W2127112450 @default.
• W3045806320 cites W2128442121 @default.
• W3045806320 cites W2136566605 @default.
• W3045806320 cites W2144199131 @default.
• W3045806320 cites W2157499457 @default.
• W3045806320 cites W2158749549 @default.
• W3045806320 cites W2163987489 @default.
• W3045806320 cites W2166230193 @default.
• W3045806320 cites W2168425425 @default.
• W3045806320 cites W2278883275 @default.
• W3045806320 cites W2736730167 @default.
• W3045806320 cites W2754805038 @default.
• W3045806320 cites W2755640313 @default.
• W3045806320 cites W2766031309 @default.
• W3045806320 cites W2767349460 @default.
• W3045806320 cites W3006410918 @default.
• W3045806320 doi "https://doi.org/10.1093/toxsci/kfaa107" @default.
• W3045806320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7818899" @default.
• W3045806320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32726451" @default.
• W3045806320 hasPublicationYear "2020" @default.
• W3045806320 type Work @default.
• W3045806320 sameAs 3045806320 @default.
• W3045806320 citedByCount "13" @default.
• W3045806320 countsByYear W30458063202020 @default.
• W3045806320 countsByYear W30458063202021 @default.
• W3045806320 countsByYear W30458063202022 @default.
• W3045806320 countsByYear W30458063202023 @default.
• W3045806320 crossrefType "journal-article" @default.
• W3045806320 hasAuthorship W3045806320A5001364718 @default.
• W3045806320 hasAuthorship W3045806320A5010768908 @default.
• W3045806320 hasAuthorship W3045806320A5018499913 @default.
• W3045806320 hasAuthorship W3045806320A5040215906 @default.
• W3045806320 hasAuthorship W3045806320A5058280342 @default.
• W3045806320 hasAuthorship W3045806320A5063079542 @default.
• W3045806320 hasAuthorship W3045806320A5073980001 @default.
• W3045806320 hasBestOaLocation W30458063201 @default.
• W3045806320 hasConcept C104317684 @default.
• W3045806320 hasConcept C114246631 @default.
• W3045806320 hasConcept C126322002 @default.
• W3045806320 hasConcept C13002179 @default.
• W3045806320 hasConcept C153911025 @default.
• W3045806320 hasConcept C181199279 @default.
• W3045806320 hasConcept C185592680 @default.
• W3045806320 hasConcept C2776256026 @default.
• W3045806320 hasConcept C2780768313 @default.
• W3045806320 hasConcept C502942594 @default.
• W3045806320 hasConcept C526171541 @default.
• W3045806320 hasConcept C55493867 @default.
• W3045806320 hasConcept C555283112 @default.
• W3045806320 hasConcept C71924100 @default.
• W3045806320 hasConcept C86745063 @default.
• W3045806320 hasConcept C86803240 @default.
• W3045806320 hasConceptScore W3045806320C104317684 @default.
• W3045806320 hasConceptScore W3045806320C114246631 @default.
• W3045806320 hasConceptScore W3045806320C126322002 @default.
• W3045806320 hasConceptScore W3045806320C13002179 @default.
• W3045806320 hasConceptScore W3045806320C153911025 @default.
• W3045806320 hasConceptScore W3045806320C181199279 @default.
• W3045806320 hasConceptScore W3045806320C185592680 @default.
• W3045806320 hasConceptScore W3045806320C2776256026 @default.
• W3045806320 hasConceptScore W3045806320C2780768313 @default.
• W3045806320 hasConceptScore W3045806320C502942594 @default.
• W3045806320 hasConceptScore W3045806320C526171541 @default.

• next