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- W3045906740 endingPage "152273" @default.
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- W3045906740 abstract "Heterocyclic compounds with two to three nitrogen atoms play a pivotal role in the normal life cycle of a cell. Further the design and synthesis of a quality heterocyclic compound library with N-atoms as new chemical probes active, is vital in drug discovery. In this context, an efficient one-pot multicomponent strategy for the synthesis of a mini library of 1,4-disubstituted 1,2,3-triazoles is described. This new multicomponent one-pot method features a combination of ionic liquid supported Cu(II) precatalysts in methanol catalyzed [3+2]-cycloaddition with microwave irradiation reactions. The synthetic manipulation involved the efficient reduction of ionic liquid supported Cu(II) catalyst by methanol followed by [3+2] cycloaddition with alkynes using in situ generated azides to obtain 1,2,3-triazoles regioselectively." @default.
- W3045906740 created "2020-08-03" @default.
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- W3045906740 date "2020-09-01" @default.
- W3045906740 modified "2023-10-12" @default.
- W3045906740 title "Sequencing [3+2]-cycloaddition and multicomponent reactions: A regioselective microwave-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles using ionic liquid supported Cu(II) precatalysts in methanol" @default.
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- W3045906740 doi "https://doi.org/10.1016/j.tetlet.2020.152273" @default.
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