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- W3045931208 endingPage "589" @default.
- W3045931208 startingPage "581" @default.
- W3045931208 abstract "Reports of widespread thromboses and disseminated intravascular coagulation (DIC) in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. Key features of this disorder include a lack of bleeding risk, only mildly low platelet counts, elevated plasma fibrinogen levels, and detection of both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and complement components in regions of thrombotic microangiopathy (TMA). This disorder is not typical DIC. Rather, it might be more similar to complement-mediated TMA syndromes, which are well known to rheumatologists who care for patients with severe systemic lupus erythematosus or catastrophic antiphospholipid syndrome. This perspective has critical implications for treatment. Anticoagulation and antiviral agents are standard treatments for DIC but are gravely insufficient for any of the TMA disorders that involve disorders of complement. Mediators of TMA syndromes overlap with those released in cytokine storm, suggesting close connections between ineffective immune responses to SARS-CoV-2, severe pneumonia and life-threatening microangiopathy." @default.
- W3045931208 created "2020-08-03" @default.
- W3045931208 creator A5019135832 @default.
- W3045931208 creator A5051086832 @default.
- W3045931208 creator A5052053321 @default.
- W3045931208 creator A5088206527 @default.
- W3045931208 date "2020-07-30" @default.
- W3045931208 modified "2023-10-09" @default.
- W3045931208 title "Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications" @default.
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