FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W30459625> ?p ?o ?g. }

• W30459625 endingPage "5" @default.
• W30459625 startingPage "87" @default.
• W30459625 abstract "Cisplatin [cis-dichlorodiammineplatinum (II)] is a widely used chemotherapeutic drug that is toxic to the kidney. Concurrent administration of cysteine together with vitamin E, Crocus sativus and Nigella sativa reduced the toxicity of cisplatin in rats. When administered i.p. for 5 alternate days with 3 mg/kg cisplatin, cysteine (20 mg/kg) together with vitamin E (2 mg/rat) an extract of Crocus sativus stigmas (50 mg/kg) and Nigella sativa seed (50 mg/kg) significantly reduced blood urea nitrogen (BUN) and serum creatinine levels as well as cisplatin-induced serum total lipids increases. In contrast, the protective agents given together with cisplatin led to an even greater decrease in blood glucose than that seen with cisplatin alone. The serum activities of alkaline phosphatase, lactate dehydrogenase, malate dehydrogenase, aspartate aminotransferase and alanine aminotransferase of cisplatin-treated rats were significantly decreased, whereas the activities of glutathione reductase and isocitrate dehydrogenase were significantly increased. Addition of cysteine and vitamin E, Crocus sativus and Nigella sativa in combination with cisplatin partially prevented many changes in the activities of serum enzymes. In cisplatin-treated rats, the liver activities of isocitrate dehydrogenase and aspartate aminotransferase were significantly increased, whereas much greater changes were found in the kidneys, with increased activity of glucose-6-phosphate dehydrogenase and decreased activities of alkaline phosphatase, isocitrate dehydrogenase, malate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, sorbitol dehydrogenase and gamma-glutamyl transferase, as well as a decreased phosphorylation to oxidation ratio in the mitochondria, indicating reduced adenosine triphosphate production. Also, administration of cysteine and vitamin E, Crocus sativus and Nigella sativa together with cisplatin partially reversed many of the kidney enzymes changes induced by cisplatin. Cysteine together with vitamin E, Crocus sativus and Nigella sativa tended to protect from cisplatin-induced falls in leucocyte counts, haemoglobin levels and mean osmotic fragility of erythrocytes and also prevented the increase in haematocrit. The results of this study indicate a basis for the toxic effects of cisplatin, and suggest a possible way of counteracting the toxicity by introducing protective agents such sulphydryl compounds, other antioxidants and extracts of natural products. It also appears that cells adapt to the effects of cisplatin through the induction of systems that produce NADPH, which in turn compensates the decrease of free sulphydryl groups. We conclude that cysteine and vitamin E, Crocus sativus and Nigella Sativa may be a promising compound for reducing cisplatin-toxic side effects including nephrotoxicity." @default.
• W30459625 created "2016-06-24" @default.
• W30459625 creator A5010256930 @default.
• W30459625 date "1998-06-04" @default.
• W30459625 modified "2023-09-29" @default.
• W30459625 title "Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats." @default.
• W30459625 cites W1495507584 @default.
• W30459625 cites W1557404598 @default.
• W30459625 cites W1564371229 @default.
• W30459625 cites W1593858516 @default.
• W30459625 cites W174629306 @default.
• W30459625 cites W1775749144 @default.
• W30459625 cites W183162221 @default.
• W30459625 cites W1949312189 @default.
• W30459625 cites W1952039521 @default.
• W30459625 cites W1955042231 @default.
• W30459625 cites W1964574933 @default.
• W30459625 cites W1967094642 @default.
• W30459625 cites W1982628995 @default.
• W30459625 cites W2007255434 @default.
• W30459625 cites W2023496931 @default.
• W30459625 cites W2058511378 @default.
• W30459625 cites W2090343590 @default.
• W30459625 cites W2096018097 @default.
• W30459625 cites W2112005204 @default.
• W30459625 cites W2114066368 @default.
• W30459625 cites W2114640031 @default.
• W30459625 cites W2137374008 @default.
• W30459625 cites W2142426473 @default.
• W30459625 cites W2152718737 @default.
• W30459625 cites W2156683218 @default.
• W30459625 cites W2262733167 @default.
• W30459625 cites W2264872423 @default.
• W30459625 cites W2298931437 @default.
• W30459625 cites W2418597864 @default.
• W30459625 cites W2473334124 @default.
• W30459625 cites W3140464090 @default.
• W30459625 cites W324869811 @default.
• W30459625 cites W78319162 @default.
• W30459625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9609969" @default.
• W30459625 hasPublicationYear "1998" @default.
• W30459625 type Work @default.
• W30459625 sameAs 30459625 @default.
• W30459625 citedByCount "103" @default.
• W30459625 countsByYear W304596252012 @default.
• W30459625 countsByYear W304596252013 @default.
• W30459625 countsByYear W304596252014 @default.
• W30459625 countsByYear W304596252015 @default.
• W30459625 countsByYear W304596252016 @default.
• W30459625 countsByYear W304596252017 @default.
• W30459625 countsByYear W304596252018 @default.
• W30459625 countsByYear W304596252019 @default.
• W30459625 countsByYear W304596252020 @default.
• W30459625 countsByYear W304596252021 @default.
• W30459625 countsByYear W304596252022 @default.
• W30459625 countsByYear W304596252023 @default.
• W30459625 crossrefType "journal-article" @default.
• W30459625 hasAuthorship W30459625A5010256930 @default.
• W30459625 hasConcept C126322002 @default.
• W30459625 hasConcept C132901563 @default.
• W30459625 hasConcept C134018914 @default.
• W30459625 hasConcept C160160445 @default.
• W30459625 hasConcept C181199279 @default.
• W30459625 hasConcept C185592680 @default.
• W30459625 hasConcept C2776694085 @default.
• W30459625 hasConcept C2777318727 @default.
• W30459625 hasConcept C2777551382 @default.
• W30459625 hasConcept C2778004101 @default.
• W30459625 hasConcept C2778239845 @default.
• W30459625 hasConcept C2779571273 @default.
• W30459625 hasConcept C29730261 @default.
• W30459625 hasConcept C538909803 @default.
• W30459625 hasConcept C55493867 @default.
• W30459625 hasConcept C556039675 @default.
• W30459625 hasConcept C71924100 @default.
• W30459625 hasConcept C86803240 @default.
• W30459625 hasConcept C98274493 @default.
• W30459625 hasConceptScore W30459625C126322002 @default.
• W30459625 hasConceptScore W30459625C132901563 @default.
• W30459625 hasConceptScore W30459625C134018914 @default.
• W30459625 hasConceptScore W30459625C160160445 @default.
• W30459625 hasConceptScore W30459625C181199279 @default.
• W30459625 hasConceptScore W30459625C185592680 @default.
• W30459625 hasConceptScore W30459625C2776694085 @default.
• W30459625 hasConceptScore W30459625C2777318727 @default.
• W30459625 hasConceptScore W30459625C2777551382 @default.
• W30459625 hasConceptScore W30459625C2778004101 @default.
• W30459625 hasConceptScore W30459625C2778239845 @default.
• W30459625 hasConceptScore W30459625C2779571273 @default.
• W30459625 hasConceptScore W30459625C29730261 @default.
• W30459625 hasConceptScore W30459625C538909803 @default.
• W30459625 hasConceptScore W30459625C55493867 @default.
• W30459625 hasConceptScore W30459625C556039675 @default.
• W30459625 hasConceptScore W30459625C71924100 @default.
• W30459625 hasConceptScore W30459625C86803240 @default.
• W30459625 hasConceptScore W30459625C98274493 @default.
• W30459625 hasIssue "2" @default.
• W30459625 hasLocation W304596251 @default.

• next