FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045968613> ?p ?o ?g. }

• W3045968613 abstract "MicroRNA (miRNA/miR)‑92a has been identified as being significantly downregulated in non‑small cell lung cancer (NSCLC) tissues using a miRNA array. However, its biological function and molecular mechanisms in NSCLC have not been fully elucidated. The aim of the present study was to determine the role of miR‑92a in NSCLC and the mechanisms by which it affects NSCLC cells. The expression levels of miR‑92a in NSCLC tissues and cell lines were analyzed using reverse transcription‑quantitative PCR. Cell viability and cell apoptosis were determined using an MTT assay and flow cytometry, respectively. It was observed that miR‑92a was significantly upregulated in NSCLC tissues and cell lines. Inhibition of miR‑92a significantly suppressed viability of NSCLC cells, with concomitant downregulation of key proliferative genes, such as proliferating cell nuclear antigen and Ki‑67. miR‑92a downregulation induced apoptosis of NSCLC cells, as evidenced by flow cytometry and apoptosis‑related protein detection. Luciferase assays confirmed that miR‑92a could directly bind to the 3'‑untranslated region of tumor suppressor F‑box/WD repeat‑containing protein 7 (FBXW7) and suppress its translation. Furthermore, small interfering RNA‑mediated FBXW7 inhibition partially attenuated the tumor suppressive effect of an miR‑92a inhibitor on NSCLC cells. Collectively, these findings demonstrated that miR‑92a might function as an oncogene in NSCLC by regulating FBXW7. In conclusion, miR‑92a could serve as a potential therapeutic target in NSCLC treatment." @default.
• W3045968613 created "2020-08-03" @default.
• W3045968613 creator A5008921281 @default.
• W3045968613 creator A5031076461 @default.
• W3045968613 creator A5039384822 @default.
• W3045968613 creator A5052782592 @default.
• W3045968613 creator A5073000623 @default.
• W3045968613 creator A5083523702 @default.
• W3045968613 date "2020-07-28" @default.
• W3045968613 modified "2023-09-27" @default.
• W3045968613 title "MicroRNA‑92a promotes non‑small cell lung cancer cell growth by targeting tumor suppressor gene FBXW7" @default.
• W3045968613 cites W1607015107 @default.
• W3045968613 cites W1870833572 @default.
• W3045968613 cites W1966358179 @default.
• W3045968613 cites W1976672798 @default.
• W3045968613 cites W1978637534 @default.
• W3045968613 cites W1994089958 @default.
• W3045968613 cites W2014946489 @default.
• W3045968613 cites W2026192997 @default.
• W3045968613 cites W2032923154 @default.
• W3045968613 cites W2034012101 @default.
• W3045968613 cites W2042907812 @default.
• W3045968613 cites W2055074145 @default.
• W3045968613 cites W2065982844 @default.
• W3045968613 cites W2079479637 @default.
• W3045968613 cites W2088214323 @default.
• W3045968613 cites W2107277218 @default.
• W3045968613 cites W2110666579 @default.
• W3045968613 cites W2142183096 @default.
• W3045968613 cites W2161817637 @default.
• W3045968613 cites W2162865290 @default.
• W3045968613 cites W2169751384 @default.
• W3045968613 cites W2185440705 @default.
• W3045968613 cites W2514635544 @default.
• W3045968613 cites W2570031935 @default.
• W3045968613 cites W2572916237 @default.
• W3045968613 cites W2614965957 @default.
• W3045968613 cites W2688299637 @default.
• W3045968613 cites W2735700214 @default.
• W3045968613 cites W2744829639 @default.
• W3045968613 cites W2747123128 @default.
• W3045968613 cites W2796860503 @default.
• W3045968613 cites W2803645040 @default.
• W3045968613 cites W2883184095 @default.
• W3045968613 cites W2917837889 @default.
• W3045968613 cites W2930779280 @default.
• W3045968613 cites W2944041115 @default.
• W3045968613 cites W2971428064 @default.
• W3045968613 cites W2973719257 @default.
• W3045968613 cites W3025194642 @default.
• W3045968613 doi "https://doi.org/10.3892/mmr.2020.11373" @default.
• W3045968613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7453619" @default.
• W3045968613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32945381" @default.
• W3045968613 hasPublicationYear "2020" @default.
• W3045968613 type Work @default.
• W3045968613 sameAs 3045968613 @default.
• W3045968613 citedByCount "3" @default.
• W3045968613 countsByYear W30459686132022 @default.
• W3045968613 crossrefType "journal-article" @default.
• W3045968613 hasAuthorship W3045968613A5008921281 @default.
• W3045968613 hasAuthorship W3045968613A5031076461 @default.
• W3045968613 hasAuthorship W3045968613A5039384822 @default.
• W3045968613 hasAuthorship W3045968613A5052782592 @default.
• W3045968613 hasAuthorship W3045968613A5073000623 @default.
• W3045968613 hasAuthorship W3045968613A5083523702 @default.
• W3045968613 hasBestOaLocation W30459686131 @default.
• W3045968613 hasConcept C104317684 @default.
• W3045968613 hasConcept C121608353 @default.
• W3045968613 hasConcept C143998085 @default.
• W3045968613 hasConcept C145059251 @default.
• W3045968613 hasConcept C1491633281 @default.
• W3045968613 hasConcept C179185449 @default.
• W3045968613 hasConcept C2776256026 @default.
• W3045968613 hasConcept C2778264664 @default.
• W3045968613 hasConcept C2781018059 @default.
• W3045968613 hasConcept C29537977 @default.
• W3045968613 hasConcept C502942594 @default.
• W3045968613 hasConcept C54355233 @default.
• W3045968613 hasConcept C555283112 @default.
• W3045968613 hasConcept C62112901 @default.
• W3045968613 hasConcept C67082663 @default.
• W3045968613 hasConcept C71924100 @default.
• W3045968613 hasConcept C86803240 @default.
• W3045968613 hasConceptScore W3045968613C104317684 @default.
• W3045968613 hasConceptScore W3045968613C121608353 @default.
• W3045968613 hasConceptScore W3045968613C143998085 @default.
• W3045968613 hasConceptScore W3045968613C145059251 @default.
• W3045968613 hasConceptScore W3045968613C1491633281 @default.
• W3045968613 hasConceptScore W3045968613C179185449 @default.
• W3045968613 hasConceptScore W3045968613C2776256026 @default.
• W3045968613 hasConceptScore W3045968613C2778264664 @default.
• W3045968613 hasConceptScore W3045968613C2781018059 @default.
• W3045968613 hasConceptScore W3045968613C29537977 @default.
• W3045968613 hasConceptScore W3045968613C502942594 @default.
• W3045968613 hasConceptScore W3045968613C54355233 @default.
• W3045968613 hasConceptScore W3045968613C555283112 @default.
• W3045968613 hasConceptScore W3045968613C62112901 @default.
• W3045968613 hasConceptScore W3045968613C67082663 @default.
• W3045968613 hasConceptScore W3045968613C71924100 @default.
• W3045968613 hasConceptScore W3045968613C86803240 @default.

• next