Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045970545> ?p ?o ?g. }
- W3045970545 endingPage "118803" @default.
- W3045970545 startingPage "118803" @default.
- W3045970545 abstract "The ability of hemoglobin (Hb) to transport respiratory gases is directly linked to its quaternary structure properties and reversible changes between T (tense) and R (relax) state. In this study we demonstrated that packed red blood cells (pRBCs) storage resulted in a gradual increase in the irreversible changes in the secondary and quaternary structures of Hb, with subsequent impairment of the T↔R transition. Such alteration was associated with the presence of irreversibly settled in the relaxed form, quaternary structure of Hb, which we termed R′. On the secondary structure level, disordered protein organization involved formation of β-sheets and a decrease in α-helices related to the aggregation process stabilized by strong intermolecular hydrogen bonding. Compensatory changes in RBCs metabolism launched to preserve reductive microenvironment were disclosed as an activation of nicotinamide adenine dinucleotide phosphate (NADPH) production and increased reduced to oxidized glutathione (GSH/GSSG) ratio. For the first time we showed the relationship between secondary structure changes and the occurrence of newly discovered R′, which through an artificial increase in oxyhemoglobin level altered Hb ability to bind and release oxygen." @default.
- W3045970545 created "2020-08-03" @default.
- W3045970545 creator A5001533767 @default.
- W3045970545 creator A5003930473 @default.
- W3045970545 creator A5008020701 @default.
- W3045970545 creator A5015594239 @default.
- W3045970545 creator A5020377974 @default.
- W3045970545 creator A5031283150 @default.
- W3045970545 creator A5040870746 @default.
- W3045970545 creator A5045778168 @default.
- W3045970545 creator A5052302178 @default.
- W3045970545 creator A5064486456 @default.
- W3045970545 date "2020-11-01" @default.
- W3045970545 modified "2023-10-16" @default.
- W3045970545 title "Irreversible alterations in the hemoglobin structure affect oxygen binding in human packed red blood cells" @default.
- W3045970545 cites W110015758 @default.
- W3045970545 cites W1499271041 @default.
- W3045970545 cites W1502235800 @default.
- W3045970545 cites W1505504761 @default.
- W3045970545 cites W1567917784 @default.
- W3045970545 cites W188594493 @default.
- W3045970545 cites W1948485836 @default.
- W3045970545 cites W1966434594 @default.
- W3045970545 cites W1972297061 @default.
- W3045970545 cites W1991027810 @default.
- W3045970545 cites W1992045220 @default.
- W3045970545 cites W1999924595 @default.
- W3045970545 cites W2000040838 @default.
- W3045970545 cites W2010281540 @default.
- W3045970545 cites W2011289735 @default.
- W3045970545 cites W2030824516 @default.
- W3045970545 cites W2031905943 @default.
- W3045970545 cites W2038149917 @default.
- W3045970545 cites W2038889059 @default.
- W3045970545 cites W2040217489 @default.
- W3045970545 cites W2051755430 @default.
- W3045970545 cites W2053478780 @default.
- W3045970545 cites W2054129051 @default.
- W3045970545 cites W2055280411 @default.
- W3045970545 cites W2061022106 @default.
- W3045970545 cites W2077637580 @default.
- W3045970545 cites W2091539702 @default.
- W3045970545 cites W2094751995 @default.
- W3045970545 cites W2098143583 @default.
- W3045970545 cites W2107921622 @default.
- W3045970545 cites W2114334714 @default.
- W3045970545 cites W2116957157 @default.
- W3045970545 cites W2128937954 @default.
- W3045970545 cites W2131699452 @default.
- W3045970545 cites W2132966139 @default.
- W3045970545 cites W2146555792 @default.
- W3045970545 cites W2161196424 @default.
- W3045970545 cites W2161860918 @default.
- W3045970545 cites W2170796558 @default.
- W3045970545 cites W2332944707 @default.
- W3045970545 cites W2398157422 @default.
- W3045970545 cites W2465584395 @default.
- W3045970545 cites W2510713318 @default.
- W3045970545 cites W2551637661 @default.
- W3045970545 cites W2562284369 @default.
- W3045970545 cites W2605832324 @default.
- W3045970545 cites W2800066502 @default.
- W3045970545 cites W2865593160 @default.
- W3045970545 cites W2882971461 @default.
- W3045970545 cites W2902894605 @default.
- W3045970545 cites W2905415733 @default.
- W3045970545 cites W2909799267 @default.
- W3045970545 cites W2954863422 @default.
- W3045970545 cites W3029553802 @default.
- W3045970545 cites W758260955 @default.
- W3045970545 cites W786125826 @default.
- W3045970545 doi "https://doi.org/10.1016/j.bbamcr.2020.118803" @default.
- W3045970545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32738251" @default.
- W3045970545 hasPublicationYear "2020" @default.
- W3045970545 type Work @default.
- W3045970545 sameAs 3045970545 @default.
- W3045970545 citedByCount "11" @default.
- W3045970545 countsByYear W30459705452021 @default.
- W3045970545 countsByYear W30459705452022 @default.
- W3045970545 countsByYear W30459705452023 @default.
- W3045970545 crossrefType "journal-article" @default.
- W3045970545 hasAuthorship W3045970545A5001533767 @default.
- W3045970545 hasAuthorship W3045970545A5003930473 @default.
- W3045970545 hasAuthorship W3045970545A5008020701 @default.
- W3045970545 hasAuthorship W3045970545A5015594239 @default.
- W3045970545 hasAuthorship W3045970545A5020377974 @default.
- W3045970545 hasAuthorship W3045970545A5031283150 @default.
- W3045970545 hasAuthorship W3045970545A5040870746 @default.
- W3045970545 hasAuthorship W3045970545A5045778168 @default.
- W3045970545 hasAuthorship W3045970545A5052302178 @default.
- W3045970545 hasAuthorship W3045970545A5064486456 @default.
- W3045970545 hasBestOaLocation W30459705451 @default.
- W3045970545 hasConcept C104292427 @default.
- W3045970545 hasConcept C104317684 @default.
- W3045970545 hasConcept C12554922 @default.
- W3045970545 hasConcept C127503593 @default.
- W3045970545 hasConcept C178790620 @default.
- W3045970545 hasConcept C181199279 @default.