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- W3045989829 abstract "IntroductionThe effects of nusinersen in adults with SMA rely on neuromotor function scales and qualitative assessments. There are limited clinical or imaging data on muscle changes over time.MethodsTwo adult SMA patients underwent clinical assessments including measures of upper and lower limb function with Revised Upper Limb Module (RULM) and Hammersmith Function Motor Scale Expanded (HFMSE); both patients were also studied with whole-body muscle MRI (T1-weighted and Diffusion Tensor Imaging/DTI sequences), at baseline and after 10 and 24 months from the beginning of treatment with nusinersen.ResultsAfter two years of treatment, HFMSE and RULM scores were stable in both patients. DTI sequences revealed an increased number, length and organization of muscle fiber tracks, and Fractional Anisotropy (FA) values showed a significant reduction after 10 and 24 months from baseline, in their corresponding maps.DiscussionMuscle DTI imaging seems to play an interesting role to monitor treatment effects over time in adult SMA patients." @default.
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- W3045989829 date "2020-10-01" @default.
- W3045989829 modified "2023-10-18" @default.
- W3045989829 title "Muscle MRI in two SMA patients on nusinersen treatment: A two years follow-up" @default.
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- W3045989829 doi "https://doi.org/10.1016/j.jns.2020.117067" @default.
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