FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046001930> ?p ?o ?g. }

• W3046001930 endingPage "321" @default.
• W3046001930 startingPage "309" @default.
• W3046001930 abstract "Poor sociability and aggressive behavior are key clinical features of opioid use disorders. The corticotropin-releasing factor (CRF) system may mediate behavioral effects of substances of abuse but its implication in substance-induced social behavior deficits and outward-directed hostility remains largely unknown. CRF signaling is mediated by two receptor types, termed CRF1 and CRF2 . The present study aimed at understanding the role for the CRF1 receptor in social and aggressive behavior induced by withdrawal from repeated opiate administration. Thus, wild-type (CRF1 +/+), CRF1 receptor heterozygous (CRF1 +/-), and null mutant (CRF1 -/-) female and male mice were treated with saline or escalating doses of morphine (20-100 mg/kg, i.p.) during six consecutive days and tested in the three-chamber task for sociability (i.e., preference for an unfamiliar same-sex conspecific vs. an object) 7 days after the last administration. Moreover, aggressive biting behavior toward the unfamiliar conspecific was assessed during the three-chamber test. Opiate withdrawal disrupted sociability in CRF1 +/+ and CRF1 +/-, but not in CRF1 -/-, female mice, without affecting aggressive biting behavior in any genotype. In contrast, opiate withdrawal did not affect sociability but increased aggressive biting behavior in male mice, independently of CRF1 receptor-deficiency. Nevertheless, in opiate-withdrawn CRF1 +/+, but not CRF1 +/- and CRF1 -/-, male mice, sociability directly correlated with aggressive biting behavior, suggesting a role for the CRF1 receptor in hostility-linked social approach. These findings demonstrate the implication of the CRF1 receptor in social behavior deficits associated with repeated opiate administration and withdrawal, revealing a new potential target for the treatment of opioid use disorders." @default.
• W3046001930 created "2020-08-03" @default.
• W3046001930 creator A5038228919 @default.
• W3046001930 creator A5049021984 @default.
• W3046001930 date "2020-07-29" @default.
• W3046001930 modified "2023-10-17" @default.
• W3046001930 title "The CRF ₁ receptor mediates social behavior deficits induced by opiate withdrawal" @default.
• W3046001930 cites W1572525448 @default.
• W3046001930 cites W1981032504 @default.
• W3046001930 cites W1986576876 @default.
• W3046001930 cites W1991882455 @default.
• W3046001930 cites W1997849212 @default.
• W3046001930 cites W2002528951 @default.
• W3046001930 cites W2012362422 @default.
• W3046001930 cites W2013424060 @default.
• W3046001930 cites W2023487969 @default.
• W3046001930 cites W2024239674 @default.
• W3046001930 cites W2029143444 @default.
• W3046001930 cites W2040543503 @default.
• W3046001930 cites W2042065498 @default.
• W3046001930 cites W2045218508 @default.
• W3046001930 cites W2045568037 @default.
• W3046001930 cites W2048116738 @default.
• W3046001930 cites W2054913542 @default.
• W3046001930 cites W2058612509 @default.
• W3046001930 cites W2066349557 @default.
• W3046001930 cites W2072168887 @default.
• W3046001930 cites W2075455407 @default.
• W3046001930 cites W2087484885 @default.
• W3046001930 cites W2098277878 @default.
• W3046001930 cites W2115251418 @default.
• W3046001930 cites W2136518312 @default.
• W3046001930 cites W2148194000 @default.
• W3046001930 cites W2155914606 @default.
• W3046001930 cites W2168521535 @default.
• W3046001930 cites W2259890699 @default.
• W3046001930 cites W2344624883 @default.
• W3046001930 cites W2551050667 @default.
• W3046001930 cites W2582500699 @default.
• W3046001930 cites W2594351553 @default.
• W3046001930 cites W2597126469 @default.
• W3046001930 cites W2745332281 @default.
• W3046001930 cites W2792721779 @default.
• W3046001930 cites W2799505340 @default.
• W3046001930 cites W2947180809 @default.
• W3046001930 cites W2951707760 @default.
• W3046001930 cites W2981642393 @default.
• W3046001930 cites W3031518915 @default.
• W3046001930 cites W3043305063 @default.
• W3046001930 cites W4247665917 @default.
• W3046001930 doi "https://doi.org/10.1002/jnr.24697" @default.
• W3046001930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32725663" @default.
• W3046001930 hasPublicationYear "2020" @default.
• W3046001930 type Work @default.
• W3046001930 sameAs 3046001930 @default.
• W3046001930 citedByCount "4" @default.
• W3046001930 countsByYear W30460019302021 @default.
• W3046001930 countsByYear W30460019302022 @default.
• W3046001930 countsByYear W30460019302023 @default.
• W3046001930 crossrefType "journal-article" @default.
• W3046001930 hasAuthorship W3046001930A5038228919 @default.
• W3046001930 hasAuthorship W3046001930A5049021984 @default.
• W3046001930 hasConcept C126322002 @default.
• W3046001930 hasConcept C134018914 @default.
• W3046001930 hasConcept C138496976 @default.
• W3046001930 hasConcept C15744967 @default.
• W3046001930 hasConcept C170493617 @default.
• W3046001930 hasConcept C18903297 @default.
• W3046001930 hasConcept C2776039942 @default.
• W3046001930 hasConcept C2778140631 @default.
• W3046001930 hasConcept C2781214261 @default.
• W3046001930 hasConcept C70410870 @default.
• W3046001930 hasConcept C71924100 @default.
• W3046001930 hasConcept C86803240 @default.
• W3046001930 hasConceptScore W3046001930C126322002 @default.
• W3046001930 hasConceptScore W3046001930C134018914 @default.
• W3046001930 hasConceptScore W3046001930C138496976 @default.
• W3046001930 hasConceptScore W3046001930C15744967 @default.
• W3046001930 hasConceptScore W3046001930C170493617 @default.
• W3046001930 hasConceptScore W3046001930C18903297 @default.
• W3046001930 hasConceptScore W3046001930C2776039942 @default.
• W3046001930 hasConceptScore W3046001930C2778140631 @default.
• W3046001930 hasConceptScore W3046001930C2781214261 @default.
• W3046001930 hasConceptScore W3046001930C70410870 @default.
• W3046001930 hasConceptScore W3046001930C71924100 @default.
• W3046001930 hasConceptScore W3046001930C86803240 @default.
• W3046001930 hasFunder F4320321589 @default.
• W3046001930 hasIssue "1" @default.
• W3046001930 hasLocation W30460019301 @default.
• W3046001930 hasLocation W30460019302 @default.
• W3046001930 hasOpenAccess W3046001930 @default.
• W3046001930 hasPrimaryLocation W30460019301 @default.
• W3046001930 hasRelatedWork W1996846474 @default.
• W3046001930 hasRelatedWork W2018368842 @default.
• W3046001930 hasRelatedWork W2033472167 @default.
• W3046001930 hasRelatedWork W2034583712 @default.
• W3046001930 hasRelatedWork W2052453588 @default.
• W3046001930 hasRelatedWork W2061429094 @default.

• next