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- W3046004490 abstract "The aim of the study was to investigate whether lifestyle factors modify the association between fat mass and obesity-associated (FTO) gene single nucleotide polymorphisms (SNPs) and obesity in a Turkish population. The study included 400 unrelated individuals, aged 24-50 years recruited in a hospital setting. Dietary intake and physical activity were assessed using 24-hour dietary recall and self-report questionnaire, respectively. A genetic risk score (GRS) was developed using FTO SNPs, rs9939609 and rs10163409. Body mass index and fat mass index were significantly associated with FTO SNP rs9939609 (p = 0.001 and p = 0.002, respectively) and GRS (p = 0.002 and p = 0.003, respectively). The interactions between SNP rs9939609 and physical activity on adiponectin concentrations, and SNP rs10163409 and dietary protein intake on increased waist circumference were statistically significant (Pinteraction = 0.027 and Pinteraction = 0.044, respectively). Our study has demonstrated that the association between FTO SNPs and central obesity might be modified by lifestyle factors in this Turkish population." @default.
- W3046004490 created "2020-08-03" @default.
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- W3046004490 date "2020-08-04" @default.
- W3046004490 modified "2023-10-16" @default.
- W3046004490 title "<i>FTO</i> gene–lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population" @default.
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- W3046004490 doi "https://doi.org/10.1080/09637486.2020.1802580" @default.
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