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- W3046108304 abstract "Paraquat (PQ) produces hippocampal neuronal cell death and cognitive dysfunctions after unique and continued exposure, but the mechanisms are not understood. Primary hippocampal wildtype or βAPP-Tau silenced cells were co-treated with PQ with or without E2, N-acetylcysteine (NAC), NS-398 (cyclooxygenase-2 inhibitor), MF63 (PGES-1 inhibitor) and/or recombinant brain-derived neurotrophic factor (BDNF) during one- and fourteen-days to studied PQ effect on prostaglandin E2 (PGE2) and BDNF signaling and their involvement in hyperphosphorylated Tau (pTau) and amyloid-beta (Aβ) protein formation, and oxidative stress generation, that lead to neuronal cell loss through estrogenic disruption, as a possible mechanism of cognitive dysfunctions produced by PQ. Our results indicate that PQ overexpressed cyclooxygenase-2 that leads to an increase of PGE2 and alters the expression of EP1-3 receptor subtypes. PQ induced also a decrease of proBDNF and mature BDNF levels and altered P75NTR and tropomyosin receptor kinase B (TrkB) expression. PQ induced PGE2 and BDNF signaling dysfunction, mediated through estrogenic disruption, leading to Aβ and pTau proteins synthesis, oxidative stress generation and finally to cell death. Our research provides relevant information to explain PQ hippocampal neurotoxic effects, indicating a probable explanation of the cognitive dysfunction observed and suggests new therapeutic strategies to protect against PQ toxic effects." @default.
- W3046108304 created "2020-08-03" @default.
- W3046108304 creator A5005918024 @default.
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- W3046108304 creator A5088829034 @default.
- W3046108304 date "2020-10-01" @default.
- W3046108304 modified "2023-10-16" @default.
- W3046108304 title "Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment" @default.
- W3046108304 cites W1491493125 @default.
- W3046108304 cites W1495431645 @default.
- W3046108304 cites W1497879779 @default.
- W3046108304 cites W1505877076 @default.
- W3046108304 cites W1560108392 @default.
- W3046108304 cites W1560763587 @default.
- W3046108304 cites W1561114541 @default.
- W3046108304 cites W1800831454 @default.
- W3046108304 cites W1840619906 @default.
- W3046108304 cites W1879925795 @default.
- W3046108304 cites W1946356711 @default.
- W3046108304 cites W1966412118 @default.
- W3046108304 cites W1966507933 @default.
- W3046108304 cites W1968906215 @default.
- W3046108304 cites W1971776712 @default.
- W3046108304 cites W1971823888 @default.
- W3046108304 cites W1974138151 @default.
- W3046108304 cites W1981166958 @default.
- W3046108304 cites W1995205013 @default.
- W3046108304 cites W1996205480 @default.
- W3046108304 cites W1998521301 @default.
- W3046108304 cites W2001236923 @default.
- W3046108304 cites W2002940154 @default.
- W3046108304 cites W2004863987 @default.
- W3046108304 cites W2006021491 @default.
- W3046108304 cites W2006338497 @default.
- W3046108304 cites W2006819998 @default.
- W3046108304 cites W2007023620 @default.
- W3046108304 cites W2007151209 @default.
- W3046108304 cites W2009582310 @default.
- W3046108304 cites W2010352524 @default.
- W3046108304 cites W2012757751 @default.
- W3046108304 cites W2013357710 @default.
- W3046108304 cites W2016187305 @default.
- W3046108304 cites W2018105080 @default.
- W3046108304 cites W2018264373 @default.
- W3046108304 cites W2021190476 @default.
- W3046108304 cites W2022138419 @default.
- W3046108304 cites W2031266783 @default.
- W3046108304 cites W2032168023 @default.
- W3046108304 cites W2033045687 @default.
- W3046108304 cites W2034134656 @default.
- W3046108304 cites W2038468202 @default.
- W3046108304 cites W2038511780 @default.
- W3046108304 cites W2040835222 @default.
- W3046108304 cites W2042877805 @default.
- W3046108304 cites W2043475021 @default.
- W3046108304 cites W2046113864 @default.
- W3046108304 cites W2047019449 @default.
- W3046108304 cites W2049501623 @default.
- W3046108304 cites W2054222041 @default.
- W3046108304 cites W2055830074 @default.
- W3046108304 cites W2058996741 @default.
- W3046108304 cites W2068083379 @default.
- W3046108304 cites W2071161130 @default.
- W3046108304 cites W2072245525 @default.
- W3046108304 cites W2073998469 @default.
- W3046108304 cites W2076243961 @default.
- W3046108304 cites W2080043648 @default.
- W3046108304 cites W2081110561 @default.
- W3046108304 cites W2083042145 @default.
- W3046108304 cites W2083977078 @default.
- W3046108304 cites W2084188625 @default.
- W3046108304 cites W2086516713 @default.
- W3046108304 cites W2088646118 @default.
- W3046108304 cites W2094765619 @default.
- W3046108304 cites W2107277218 @default.
- W3046108304 cites W2110931346 @default.
- W3046108304 cites W2112541356 @default.
- W3046108304 cites W2127027544 @default.
- W3046108304 cites W2128186728 @default.
- W3046108304 cites W2141784137 @default.
- W3046108304 cites W2142819123 @default.
- W3046108304 cites W2151975818 @default.
- W3046108304 cites W2153688892 @default.
- W3046108304 cites W2159545830 @default.
- W3046108304 cites W2172012214 @default.
- W3046108304 cites W2214469490 @default.
- W3046108304 cites W2225673876 @default.
- W3046108304 cites W2344082772 @default.
- W3046108304 cites W2394347777 @default.
- W3046108304 cites W2476380430 @default.
- W3046108304 cites W2513319790 @default.
- W3046108304 cites W2514934551 @default.
- W3046108304 cites W2573640428 @default.