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- W3046112613 abstract "Background: Chiral safety, especially chiral drug inversion in vivo, is the top priority of current scientific research. Medicine researchers and pharmacists often ignore that one enantiomer will be converted or partially converted to another enantiomer when it is ingested in vivo. So that, in the context that more than 50% of the listed drugs are chiral drugs, it is necessary and important to pay attention to the inversion of chiral drugs. Methods: The metabolic and stereoselective pharmacokinetic characteristics of seven chiral drugs with one chiral center in the hydroxy group were reviewed in vivo and in vitro including the possible chiral inversion of each drug enantiomer. These seven drugs include (S)-Mandelic acid, RS-8359, Tramadol, Venlafaxine, Carvedilol, Fluoxetine and Metoprolol. Results: The differences in stereoselective pharmacokinetics could be found for all the seven chiral drugs, since R and S isomers often exhibit different PK and PD properties. However, not every drug has shown the properties of one direction or two direction chiral inversion. For chiral hydroxyl group drugs, the redox enzyme system may be one of the key factors for chiral inversion in vivo. Conclusion: In vitro and in vivo chiral inversion is a very complex problem and may occur during every process of ADME. Nowadays, research on chiral metabolism in the liver has the most attention, while neglecting the chiral transformation of other processes. Our review may provide the basis for the drug R&D and the safety of drugs in clinical therapy." @default.
- W3046112613 created "2020-08-03" @default.
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- W3046112613 date "2020-12-23" @default.
- W3046112613 modified "2023-10-16" @default.
- W3046112613 title "Stereoselective Pharmacokinetics and Chiral Inversions of Some Chiral Hydroxy Group Drugs" @default.
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- W3046112613 cites W1976409698 @default.
- W3046112613 cites W1978929135 @default.
- W3046112613 cites W1987327645 @default.
- W3046112613 cites W1992568187 @default.
- W3046112613 cites W1995687294 @default.
- W3046112613 cites W1999266078 @default.
- W3046112613 cites W2000854346 @default.
- W3046112613 cites W2002205150 @default.
- W3046112613 cites W2004614455 @default.
- W3046112613 cites W2014218355 @default.
- W3046112613 cites W2028810929 @default.
- W3046112613 cites W2030689272 @default.
- W3046112613 cites W2036566711 @default.
- W3046112613 cites W2044778029 @default.
- W3046112613 cites W2048667544 @default.
- W3046112613 cites W2051936456 @default.
- W3046112613 cites W2053093757 @default.
- W3046112613 cites W2063288595 @default.
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- W3046112613 cites W2080103183 @default.
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- W3046112613 cites W2113533305 @default.
- W3046112613 cites W2122031040 @default.
- W3046112613 cites W2122952227 @default.
- W3046112613 cites W2127965116 @default.
- W3046112613 cites W2130821845 @default.
- W3046112613 cites W2141486397 @default.
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- W3046112613 cites W2322189744 @default.
- W3046112613 cites W2323340851 @default.
- W3046112613 cites W2325537315 @default.
- W3046112613 cites W2325852025 @default.
- W3046112613 cites W2331019073 @default.
- W3046112613 cites W2340330252 @default.
- W3046112613 cites W2341411384 @default.
- W3046112613 cites W2413335950 @default.
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- W3046112613 doi "https://doi.org/10.2174/1389201021666200727144053" @default.
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