FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046129861> ?p ?o ?g. }

• W3046129861 abstract "Abstract Cancer incidence varies by tissue due to differences in environmental risk factor exposure, gene variant inheritance, and lifetime number of stem cell divisions in a tissue. Folate deficiency is associated with increased risk for colorectal cancer (CRC) and acute lymphocytic leukemia. Conversely, high folic acid (FA) intake has been associated with higher CRC risk. However, the mutagenic potential of FA intake in different tissues has not been characterized. Here we quantified mutations in folate-susceptible somatic tissues, namely bone marrow and colon, from the same MutaMouse mice and determined the FA-induced mutation profiles of both tissues using next generation sequencing. FA-induced mutagenesis was tissue- and dose-specific: FA deficiency increased mutant frequency (MF) in bone marrow while FA supplementation increased MF in colon. Analyses of mutation profiles suggested that FA interacted with mutagenic mechanisms that are unique to each tissue. These data illuminate potential mechanisms underpinning differences in susceptibility to FA-related cancers." @default.
• W3046129861 created "2020-08-03" @default.
• W3046129861 creator A5006764800 @default.
• W3046129861 creator A5036062143 @default.
• W3046129861 creator A5049171921 @default.
• W3046129861 creator A5069078991 @default.
• W3046129861 creator A5076669667 @default.
• W3046129861 creator A5083742987 @default.
• W3046129861 creator A5089922870 @default.
• W3046129861 date "2020-07-29" @default.
• W3046129861 modified "2023-10-18" @default.
• W3046129861 title "Mutagenicity of folic acid deficiency and supplementation is tissue-specific and results in distinct mutation profiles" @default.
• W3046129861 cites W1414459154 @default.
• W3046129861 cites W157532068 @default.
• W3046129861 cites W1785260648 @default.
• W3046129861 cites W1831301545 @default.
• W3046129861 cites W1836124358 @default.
• W3046129861 cites W1966016371 @default.
• W3046129861 cites W1982079000 @default.
• W3046129861 cites W1989449389 @default.
• W3046129861 cites W2002757935 @default.
• W3046129861 cites W2011006722 @default.
• W3046129861 cites W2016142365 @default.
• W3046129861 cites W2019078072 @default.
• W3046129861 cites W2027069016 @default.
• W3046129861 cites W2029030998 @default.
• W3046129861 cites W2037898576 @default.
• W3046129861 cites W2047861739 @default.
• W3046129861 cites W2048995636 @default.
• W3046129861 cites W2060930539 @default.
• W3046129861 cites W2069902477 @default.
• W3046129861 cites W2074730941 @default.
• W3046129861 cites W2083791611 @default.
• W3046129861 cites W2089594231 @default.
• W3046129861 cites W2102294256 @default.
• W3046129861 cites W2102991984 @default.
• W3046129861 cites W2103274613 @default.
• W3046129861 cites W2108234281 @default.
• W3046129861 cites W2110016941 @default.
• W3046129861 cites W2110835181 @default.
• W3046129861 cites W2113665122 @default.
• W3046129861 cites W2115295015 @default.
• W3046129861 cites W2117692326 @default.
• W3046129861 cites W2122398832 @default.
• W3046129861 cites W2123411656 @default.
• W3046129861 cites W2124977765 @default.
• W3046129861 cites W2128163569 @default.
• W3046129861 cites W2132224561 @default.
• W3046129861 cites W2134429697 @default.
• W3046129861 cites W2151107273 @default.
• W3046129861 cites W2154389444 @default.
• W3046129861 cites W2158305865 @default.
• W3046129861 cites W2161927091 @default.
• W3046129861 cites W2165760244 @default.
• W3046129861 cites W2169502489 @default.
• W3046129861 cites W2170551349 @default.
• W3046129861 cites W2172294305 @default.
• W3046129861 cites W2204695746 @default.
• W3046129861 cites W2262414037 @default.
• W3046129861 cites W2413084977 @default.
• W3046129861 cites W2502471029 @default.
• W3046129861 cites W2738934769 @default.
• W3046129861 cites W2749473676 @default.
• W3046129861 cites W2802586094 @default.
• W3046129861 cites W2889875045 @default.
• W3046129861 cites W2897064819 @default.
• W3046129861 cites W2898789672 @default.
• W3046129861 cites W2990505290 @default.
• W3046129861 cites W2999417355 @default.
• W3046129861 cites W3004480399 @default.
• W3046129861 cites W3020114628 @default.
• W3046129861 cites W4254632171 @default.
• W3046129861 cites W6525265 @default.
• W3046129861 doi "https://doi.org/10.1101/2020.07.27.223552" @default.
• W3046129861 hasPublicationYear "2020" @default.
• W3046129861 type Work @default.
• W3046129861 sameAs 3046129861 @default.
• W3046129861 citedByCount "1" @default.
• W3046129861 countsByYear W30461298612023 @default.
• W3046129861 crossrefType "posted-content" @default.
• W3046129861 hasAuthorship W3046129861A5006764800 @default.
• W3046129861 hasAuthorship W3046129861A5036062143 @default.
• W3046129861 hasAuthorship W3046129861A5049171921 @default.
• W3046129861 hasAuthorship W3046129861A5069078991 @default.
• W3046129861 hasAuthorship W3046129861A5076669667 @default.
• W3046129861 hasAuthorship W3046129861A5083742987 @default.
• W3046129861 hasAuthorship W3046129861A5089922870 @default.
• W3046129861 hasBestOaLocation W30461298611 @default.
• W3046129861 hasConcept C102306862 @default.
• W3046129861 hasConcept C104317684 @default.
• W3046129861 hasConcept C121608353 @default.
• W3046129861 hasConcept C134305767 @default.
• W3046129861 hasConcept C143065580 @default.
• W3046129861 hasConcept C16318435 @default.
• W3046129861 hasConcept C203014093 @default.
• W3046129861 hasConcept C2778461978 @default.
• W3046129861 hasConcept C2780007613 @default.
• W3046129861 hasConcept C501734568 @default.
• W3046129861 hasConcept C502942594 @default.
• W3046129861 hasConcept C526805850 @default.

• next