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- W3046162564 endingPage "112192" @default.
- W3046162564 startingPage "112192" @default.
- W3046162564 abstract "Intratumoral hypoxia has a significant impact on the development and progression of breast cancer (BC). Rather than exerting limited regional impact, hypoxia create an aggressive macroenvironment for BC. Hypoxia-inducible factors-1(HIF-1) is extensively induced under hypoxia condition of BC, activating the transcription of multiple oncogenes. Thereinto, CD73 is the one which could be secreted into the microenvironment and is in favor of the growth, metastasis, resistance to therapies, as well as the stemness maintenance of BC. In this review, we address the significance of hypoxia/HIF-1/CD73 axis for BC, and provide a novel perspective into BC therapeutic strategies." @default.
- W3046162564 created "2020-08-03" @default.
- W3046162564 creator A5035037626 @default.
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- W3046162564 creator A5081448424 @default.
- W3046162564 creator A5081588131 @default.
- W3046162564 creator A5084494795 @default.
- W3046162564 date "2020-10-01" @default.
- W3046162564 modified "2023-10-14" @default.
- W3046162564 title "Tumorigenesis and Progression As A Consequence of Hypoxic TME：A Prospective View upon Breast Cancer Therapeutic Targets" @default.
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