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• W3046175168 abstract "Abstract Purpose For optimal management of ductal carcinoma in situ (DCIS), reproducible histopathological assessment is essential to distinguish low-risk from high-risk DCIS. Therefore, we analyzed interrater reliability of histopathological DCIS features and assessed their associations with subsequent ipsilateral invasive breast cancer (iIBC) risk. Methods Using a case-cohort design, reliability was assessed in a population-based, nationwide cohort of 2767 women with screen-detected DCIS diagnosed between 1993 and 2004, treated by breast-conserving surgery with/without radiotherapy (BCS ± RT) using Krippendorff’s alpha (KA) and Gwet’s AC2 (GAC2). Thirty-eight raters scored histopathological DCIS features including grade (2-tiered and 3-tiered), growth pattern, mitotic activity, periductal fibrosis, and lymphocytic infiltrate in 342 women. Using majority opinion-based scores for each feature, their association with subsequent iIBC risk was assessed using Cox regression. Results Interrater reliability of grade using various classifications was fair to moderate, and only substantial for grade 1 versus 2 + 3 when using GAC2 (0.78). Reliability for growth pattern (KA 0.44, GAC2 0.78), calcifications (KA 0.49, GAC2 0.70) and necrosis (KA 0.47, GAC2 0.70) was moderate using KA and substantial using GAC2; for (type of) periductal fibrosis and lymphocytic infiltrate fair to moderate estimates were found and for mitotic activity reliability was substantial using GAC2 (0.70). Only in patients treated with BCS-RT, high mitotic activity was associated with a higher iIBC risk in univariable analysis (Hazard Ratio (HR) 2.53, 95% Confidence Interval (95% CI) 1.05–6.11); grade 3 versus 1 + 2 (HR 2.64, 95% CI 1.35–5.14) and a cribriform/solid versus flat epithelial atypia/clinging/(micro)papillary growth pattern (HR 3.70, 95% CI 1.34–10.23) were independently associated with a higher iIBC risk. Conclusions Using majority opinion-based scores, DCIS grade, growth pattern, and mitotic activity are associated with iIBC risk in patients treated with BCS-RT, but interrater variability is substantial. Semi-quantitative grading, incorporating and separately evaluating nuclear pleomorphism, growth pattern, and mitotic activity, may improve the reliability and prognostic value of these features." @default.
• W3046175168 created "2020-08-03" @default.
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• W3046175168 date "2020-07-30" @default.
• W3046175168 modified "2023-10-14" @default.
• W3046175168 title "Prognostic value of histopathological DCIS features in a large-scale international interrater reliability study" @default.
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• W3046175168 cites W1968325773 @default.
• W3046175168 cites W1968667761 @default.
• W3046175168 cites W1974427392 @default.
• W3046175168 cites W1979020186 @default.
• W3046175168 cites W1996290308 @default.
• W3046175168 cites W2004742825 @default.
• W3046175168 cites W2010871781 @default.
• W3046175168 cites W2011575012 @default.
• W3046175168 cites W2027138642 @default.
• W3046175168 cites W2029703151 @default.
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• W3046175168 cites W2112507926 @default.
• W3046175168 cites W2119349383 @default.
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• W3046175168 cites W2169491501 @default.
• W3046175168 cites W2321334062 @default.
• W3046175168 cites W2345358625 @default.
• W3046175168 cites W2517616992 @default.
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• W3046175168 doi "https://doi.org/10.1007/s10549-020-05816-x" @default.
• W3046175168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7497690" @default.
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