Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046182097> ?p ?o ?g. }
- W3046182097 endingPage "5429" @default.
- W3046182097 startingPage "5411" @default.
- W3046182097 abstract "Forkhead box P (FoxP) proteins are unique transcription factors that spatiotemporally regulate gene expression by tethering two chromosome loci together via functional domain-swapped dimers formed through their DNA-binding domains. Further, the differential kinetics on this dimerization mechanism underlie an intricate gene regulation network at physiological conditions. Nonetheless, poor understanding of the structural dynamics and steps of the association process impedes to link the functional domain swapping to human-associated diseases. Here, we have characterized the DNA-binding domain of human FoxP1 by integrating single-molecule Forster resonance energy transfer and hydrogen-deuterium exchange mass spectrometry data with molecular dynamics simulations. Our results confirm the formation of a previously postulated domain-swapped (DS) FoxP1 dimer in solution and reveal the presence of highly populated, heterogeneous, and locally disordered dimeric intermediates along the dimer dissociation pathway. The unique features of FoxP1 provide a glimpse of how intrinsically disordered regions can facilitate domain swapping oligomerization and other tightly regulated association mechanisms relevant in biological processes." @default.
- W3046182097 created "2020-08-03" @default.
- W3046182097 creator A5015500873 @default.
- W3046182097 creator A5016683019 @default.
- W3046182097 creator A5024407720 @default.
- W3046182097 creator A5065616216 @default.
- W3046182097 creator A5066987321 @default.
- W3046182097 creator A5074513493 @default.
- W3046182097 creator A5079620067 @default.
- W3046182097 date "2020-09-01" @default.
- W3046182097 modified "2023-09-25" @default.
- W3046182097 title "Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping" @default.
- W3046182097 cites W1513553433 @default.
- W3046182097 cites W1969312597 @default.
- W3046182097 cites W1970562061 @default.
- W3046182097 cites W1973699439 @default.
- W3046182097 cites W1974026308 @default.
- W3046182097 cites W1980956149 @default.
- W3046182097 cites W1982995354 @default.
- W3046182097 cites W1998030898 @default.
- W3046182097 cites W2003822145 @default.
- W3046182097 cites W2004437533 @default.
- W3046182097 cites W2007365285 @default.
- W3046182097 cites W2019000267 @default.
- W3046182097 cites W2025442958 @default.
- W3046182097 cites W2031528002 @default.
- W3046182097 cites W2034299708 @default.
- W3046182097 cites W2036454087 @default.
- W3046182097 cites W2038225608 @default.
- W3046182097 cites W2044882887 @default.
- W3046182097 cites W2045686993 @default.
- W3046182097 cites W2046790268 @default.
- W3046182097 cites W2048822589 @default.
- W3046182097 cites W2050538415 @default.
- W3046182097 cites W2056718503 @default.
- W3046182097 cites W2059706314 @default.
- W3046182097 cites W2069161633 @default.
- W3046182097 cites W2073341329 @default.
- W3046182097 cites W2076174368 @default.
- W3046182097 cites W2087929865 @default.
- W3046182097 cites W2107834897 @default.
- W3046182097 cites W2112154906 @default.
- W3046182097 cites W2113020073 @default.
- W3046182097 cites W2114320763 @default.
- W3046182097 cites W2114323152 @default.
- W3046182097 cites W2134399305 @default.
- W3046182097 cites W2141980994 @default.
- W3046182097 cites W2151363218 @default.
- W3046182097 cites W2157005876 @default.
- W3046182097 cites W2157456092 @default.
- W3046182097 cites W2160544821 @default.
- W3046182097 cites W2162355408 @default.
- W3046182097 cites W2163107106 @default.
- W3046182097 cites W2209466135 @default.
- W3046182097 cites W2248792970 @default.
- W3046182097 cites W2277192830 @default.
- W3046182097 cites W2410194959 @default.
- W3046182097 cites W2413483619 @default.
- W3046182097 cites W2516810373 @default.
- W3046182097 cites W2592312471 @default.
- W3046182097 cites W2735196374 @default.
- W3046182097 cites W2769305135 @default.
- W3046182097 cites W2795803259 @default.
- W3046182097 cites W2887996311 @default.
- W3046182097 cites W2891501660 @default.
- W3046182097 cites W2891867890 @default.
- W3046182097 cites W2901738728 @default.
- W3046182097 cites W2931748776 @default.
- W3046182097 cites W3099912599 @default.
- W3046182097 cites W4211156111 @default.
- W3046182097 cites W938283201 @default.
- W3046182097 doi "https://doi.org/10.1016/j.jmb.2020.07.017" @default.
- W3046182097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7663421" @default.
- W3046182097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32735805" @default.
- W3046182097 hasPublicationYear "2020" @default.
- W3046182097 type Work @default.
- W3046182097 sameAs 3046182097 @default.
- W3046182097 citedByCount "11" @default.
- W3046182097 countsByYear W30461820972021 @default.
- W3046182097 countsByYear W30461820972022 @default.
- W3046182097 countsByYear W30461820972023 @default.
- W3046182097 crossrefType "journal-article" @default.
- W3046182097 hasAuthorship W3046182097A5015500873 @default.
- W3046182097 hasAuthorship W3046182097A5016683019 @default.
- W3046182097 hasAuthorship W3046182097A5024407720 @default.
- W3046182097 hasAuthorship W3046182097A5065616216 @default.
- W3046182097 hasAuthorship W3046182097A5066987321 @default.
- W3046182097 hasAuthorship W3046182097A5074513493 @default.
- W3046182097 hasAuthorship W3046182097A5079620067 @default.
- W3046182097 hasBestOaLocation W30461820971 @default.
- W3046182097 hasConcept C104317684 @default.
- W3046182097 hasConcept C107824862 @default.
- W3046182097 hasConcept C12554922 @default.
- W3046182097 hasConcept C134306372 @default.
- W3046182097 hasConcept C185592680 @default.
- W3046182097 hasConcept C25166345 @default.
- W3046182097 hasConcept C33923547 @default.
- W3046182097 hasConcept C33987129 @default.