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• W3046200021 abstract "Unpredictable in vivo therapeutic feedback of hydroxyl radical (•OH) efficiency is the major bottleneck of chemodynamic therapy. Herein, we describe novel Fenton-based nanotheranostics NQ-Cy@Fe&GOD for spatio-temporally reporting intratumor •OH-mediated treatment, which innovatively unites dual-channel near-infrared (NIR) fluorescence and magnetic resonance imaging (MRI) signals. Specifically, MRI signal traces the dose distribution of Fenton-based iron oxide nanoparticles (IONPs) with high-spatial resolution, meanwhile timely fluorescence signal quantifies •OH-mediated therapeutic response with high spatio-temporal resolution. NQ-Cy@Fe&GOD can successfully monitor the intracellular release of IONPs and •OH-induced NQO1 enzyme in living cells and tumor-bearing mice, which makes a breakthrough in conquering the inherent unpredictable obstacles on spatio-temporally reporting chemodynamic therapy, so as to manipulate dose-dependent therapeutic process. This unprecedented strategy can elaborately bridge MRI and fluorescence imaging modality with spatio-temporal resolution, and paves a new pathway for accurately evaluating in situ generation of •OH feedback on the intratumoral catalytic Fenton reaction." @default.
• W3046200021 created "2020-08-03" @default.
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• W3046200021 date "2020-09-07" @default.
• W3046200021 modified "2023-09-23" @default.
• W3046200021 title "Spatio‐Temporally Reporting Dose‐Dependent Chemotherapy via Uniting Dual‐Modal MRI/NIR Imaging" @default.
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• W3046200021 doi "https://doi.org/10.1002/anie.202009380" @default.
• W3046200021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32729980" @default.
• W3046200021 hasPublicationYear "2020" @default.
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