Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046206656> ?p ?o ?g. }
- W3046206656 abstract "Testicular androgens during the perinatal period play an important role in the sexual differentiation of the brain of rodents. Testicular androgens transported into the brain act via androgen receptors or are the substrate of aromatase, which synthesizes neuroestrogens that act via estrogen receptors. The latter that occurs in the perinatal period significantly contributes to the sexual differentiation of the brain. The preoptic area (POA) and the bed nucleus of the stria terminalis (BNST) are sexually dimorphic brain regions that are involved in the regulation of sex-specific social behaviors and the reproductive neuroendocrine system. Here, we discuss how neuroestrogens of testicular origin act in the perinatal period to organize the sexually dimorphic structures of the POA and BNST. Accumulating data from rodent studies suggest that neuroestrogens induce the sex differences in glial and immune cells, which play an important role in the sexually dimorphic formation of the dendritic synapse patterning in the POA, and induce the sex differences in the cell number of specific neuronal cell groups in the POA and BNST, which may be established by controlling the number of cells dying by apoptosis or the phenotypic organization of living cells. Testicular androgens in the peripubertal period also contribute to the sexual differentiation of the POA and BNST, and thus their aromatization to estrogens may be unnecessary. Additionally, we discuss the notion that testicular androgens that do not aromatize to estrogens can also induce significant effects on the sexually dimorphic formation of the POA and BNST." @default.
- W3046206656 created "2020-08-03" @default.
- W3046206656 creator A5041520063 @default.
- W3046206656 creator A5091423441 @default.
- W3046206656 date "2020-07-29" @default.
- W3046206656 modified "2023-10-11" @default.
- W3046206656 title "Sexually Dimorphic Formation of the Preoptic Area and the Bed Nucleus of the Stria Terminalis by Neuroestrogens" @default.
- W3046206656 cites W1546047454 @default.
- W3046206656 cites W1564190433 @default.
- W3046206656 cites W1614504110 @default.
- W3046206656 cites W1671897850 @default.
- W3046206656 cites W1886714202 @default.
- W3046206656 cites W1916200225 @default.
- W3046206656 cites W1951315244 @default.
- W3046206656 cites W1964901370 @default.
- W3046206656 cites W1974685685 @default.
- W3046206656 cites W1982052389 @default.
- W3046206656 cites W1984547984 @default.
- W3046206656 cites W1987736972 @default.
- W3046206656 cites W1989347905 @default.
- W3046206656 cites W1994304957 @default.
- W3046206656 cites W1998210699 @default.
- W3046206656 cites W2002208801 @default.
- W3046206656 cites W2005145982 @default.
- W3046206656 cites W2012588629 @default.
- W3046206656 cites W2016988090 @default.
- W3046206656 cites W2017375798 @default.
- W3046206656 cites W2019404480 @default.
- W3046206656 cites W2020841755 @default.
- W3046206656 cites W2021007174 @default.
- W3046206656 cites W2026632778 @default.
- W3046206656 cites W2031370385 @default.
- W3046206656 cites W2032640068 @default.
- W3046206656 cites W2037007725 @default.
- W3046206656 cites W2039883513 @default.
- W3046206656 cites W2042549272 @default.
- W3046206656 cites W2042602135 @default.
- W3046206656 cites W2044730840 @default.
- W3046206656 cites W2056415305 @default.
- W3046206656 cites W2056741515 @default.
- W3046206656 cites W2057987333 @default.
- W3046206656 cites W2058382270 @default.
- W3046206656 cites W2061448412 @default.
- W3046206656 cites W2061822544 @default.
- W3046206656 cites W2063049673 @default.
- W3046206656 cites W2064131017 @default.
- W3046206656 cites W2065397280 @default.
- W3046206656 cites W2068958289 @default.
- W3046206656 cites W2069358402 @default.
- W3046206656 cites W2070780249 @default.
- W3046206656 cites W2076975631 @default.
- W3046206656 cites W2078141119 @default.
- W3046206656 cites W2084216483 @default.
- W3046206656 cites W2084737190 @default.
- W3046206656 cites W2088982569 @default.
- W3046206656 cites W2089901472 @default.
- W3046206656 cites W2090647503 @default.
- W3046206656 cites W2091053195 @default.
- W3046206656 cites W2091793491 @default.
- W3046206656 cites W2092280065 @default.
- W3046206656 cites W2093129425 @default.
- W3046206656 cites W2096521316 @default.
- W3046206656 cites W2110871106 @default.
- W3046206656 cites W2112203969 @default.
- W3046206656 cites W2113955611 @default.
- W3046206656 cites W2118750014 @default.
- W3046206656 cites W2128381336 @default.
- W3046206656 cites W2129887272 @default.
- W3046206656 cites W2132769858 @default.
- W3046206656 cites W2133423309 @default.
- W3046206656 cites W2133556177 @default.
- W3046206656 cites W2142027358 @default.
- W3046206656 cites W2142847948 @default.
- W3046206656 cites W2143333110 @default.
- W3046206656 cites W2145632985 @default.
- W3046206656 cites W2156772653 @default.
- W3046206656 cites W2159584891 @default.
- W3046206656 cites W2166224834 @default.
- W3046206656 cites W2168043444 @default.
- W3046206656 cites W2329019395 @default.
- W3046206656 cites W2467073155 @default.
- W3046206656 cites W2482212044 @default.
- W3046206656 cites W2530075663 @default.
- W3046206656 cites W2605246022 @default.
- W3046206656 cites W2622633271 @default.
- W3046206656 cites W2742742433 @default.
- W3046206656 cites W2767080260 @default.
- W3046206656 cites W2790719087 @default.
- W3046206656 cites W2889500679 @default.
- W3046206656 cites W2896833679 @default.
- W3046206656 cites W2898456571 @default.
- W3046206656 cites W2912574444 @default.
- W3046206656 cites W2988879465 @default.
- W3046206656 cites W2990751675 @default.
- W3046206656 cites W3015750866 @default.
- W3046206656 cites W3017216586 @default.
- W3046206656 doi "https://doi.org/10.3389/fnins.2020.00797" @default.
- W3046206656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7403479" @default.
- W3046206656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32848568" @default.
- W3046206656 hasPublicationYear "2020" @default.