FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046207932> ?p ?o ?g. }

• W3046207932 abstract "Abstract The activity of the epiphyseal growth plates, which drive longitudinal growth of long bones, is dependent on the ability of chondrocytes to change their shape and size extensively as they differentiate. However, organ size, extracellular matrix density and cell number have hindered the study of chondrocyte morphology. Here, we describe a new pipeline called 3D Morphometric Analysis for Phenotypic significance (3D MAPs), which overcomes these obstacles. By using 3D MAPs, we have created an image database of hundreds of thousands of cells from orthologous long bones. Analysis of this database revealed the growth strategies that chondrocytes use during differentiation. We found that chondrocytes employed both allometric and isometric growth, and that allometric growth is achieved by changes either in volume or surface area along a specific cell axis in a zone-specific manner. Additionally, we discovered a new organization of chondrocytes within the growth plate, where cells are orientated such that their longest axis always aligns with the dorsal-ventral axis of the bone. To demonstrate the ability of 3D MAPs to explore mechanisms of growth plate regulation, we studied the abnormally short tibiae of Gdf5- null mice. 3D MAPs identified aberrant cellular growth behaviors which resulted in a 3-fold reduction in volumetric cell growth, as well as affected cell morphology and orientation, highlighting GDF5 as a new regulator of growth plate activity. Overall, our findings provide new insight into the morphological sequence that chondrocytes undergo during differentiation and highlight the ability of 3D MAPs to uncover molecular and cellular mechanisms regulating this process. More broadly, this work provides a new framework for studying growth plate biology." @default.
• W3046207932 created "2020-08-03" @default.
• W3046207932 creator A5004659592 @default.
• W3046207932 creator A5014018022 @default.
• W3046207932 creator A5057786365 @default.
• W3046207932 creator A5059757659 @default.
• W3046207932 creator A5062748514 @default.
• W3046207932 creator A5076337424 @default.
• W3046207932 creator A5081367646 @default.
• W3046207932 creator A5082049684 @default.
• W3046207932 date "2020-07-28" @default.
• W3046207932 modified "2023-09-23" @default.
• W3046207932 title "3D MAPs discovers the morphological sequence chondrocytes undergo in the growth plate and the regulatory role of GDF5 in this process" @default.
• W3046207932 cites W1507864482 @default.
• W3046207932 cites W1811488600 @default.
• W3046207932 cites W1842356540 @default.
• W3046207932 cites W1865339308 @default.
• W3046207932 cites W1921141222 @default.
• W3046207932 cites W1964284160 @default.
• W3046207932 cites W1964752771 @default.
• W3046207932 cites W1970801522 @default.
• W3046207932 cites W1974296262 @default.
• W3046207932 cites W1979366429 @default.
• W3046207932 cites W1981413140 @default.
• W3046207932 cites W1987817703 @default.
• W3046207932 cites W1988554495 @default.
• W3046207932 cites W2006409124 @default.
• W3046207932 cites W2014680491 @default.
• W3046207932 cites W2034294958 @default.
• W3046207932 cites W2037707586 @default.
• W3046207932 cites W2039305820 @default.
• W3046207932 cites W2042932723 @default.
• W3046207932 cites W2054812589 @default.
• W3046207932 cites W2058396041 @default.
• W3046207932 cites W2064607834 @default.
• W3046207932 cites W2070385144 @default.
• W3046207932 cites W2073057651 @default.
• W3046207932 cites W2074522272 @default.
• W3046207932 cites W2076958216 @default.
• W3046207932 cites W2083048982 @default.
• W3046207932 cites W2083883455 @default.
• W3046207932 cites W2084417037 @default.
• W3046207932 cites W2084912223 @default.
• W3046207932 cites W2086998851 @default.
• W3046207932 cites W2099300499 @default.
• W3046207932 cites W2101360566 @default.
• W3046207932 cites W2110341920 @default.
• W3046207932 cites W2113401723 @default.
• W3046207932 cites W2116529502 @default.
• W3046207932 cites W2120402520 @default.
• W3046207932 cites W2124013993 @default.
• W3046207932 cites W2133545343 @default.
• W3046207932 cites W2136346050 @default.
• W3046207932 cites W2145405607 @default.
• W3046207932 cites W2146857985 @default.
• W3046207932 cites W2158619848 @default.
• W3046207932 cites W2160679726 @default.
• W3046207932 cites W2161247859 @default.
• W3046207932 cites W2162173421 @default.
• W3046207932 cites W2163624468 @default.
• W3046207932 cites W2167279371 @default.
• W3046207932 cites W2189480951 @default.
• W3046207932 cites W2260455672 @default.
• W3046207932 cites W2319680553 @default.
• W3046207932 cites W2409820086 @default.
• W3046207932 cites W2558556020 @default.
• W3046207932 cites W2608711007 @default.
• W3046207932 cites W2730344022 @default.
• W3046207932 cites W2762626361 @default.
• W3046207932 cites W2770430675 @default.
• W3046207932 cites W2952481429 @default.
• W3046207932 cites W2953281317 @default.
• W3046207932 cites W3009784420 @default.
• W3046207932 cites W4205089880 @default.
• W3046207932 cites W4211112402 @default.
• W3046207932 cites W4211229214 @default.
• W3046207932 cites W4247368350 @default.
• W3046207932 cites W4247817378 @default.
• W3046207932 cites W82954875 @default.
• W3046207932 doi "https://doi.org/10.1101/2020.07.28.225409" @default.
• W3046207932 hasPublicationYear "2020" @default.
• W3046207932 type Work @default.
• W3046207932 sameAs 3046207932 @default.
• W3046207932 citedByCount "0" @default.
• W3046207932 crossrefType "posted-content" @default.
• W3046207932 hasAuthorship W3046207932A5004659592 @default.
• W3046207932 hasAuthorship W3046207932A5014018022 @default.
• W3046207932 hasAuthorship W3046207932A5057786365 @default.
• W3046207932 hasAuthorship W3046207932A5059757659 @default.
• W3046207932 hasAuthorship W3046207932A5062748514 @default.
• W3046207932 hasAuthorship W3046207932A5076337424 @default.
• W3046207932 hasAuthorship W3046207932A5081367646 @default.
• W3046207932 hasAuthorship W3046207932A5082049684 @default.
• W3046207932 hasBestOaLocation W30462079321 @default.
• W3046207932 hasConcept C104317684 @default.
• W3046207932 hasConcept C105702510 @default.
• W3046207932 hasConcept C111919701 @default.
• W3046207932 hasConcept C127716648 @default.
• W3046207932 hasConcept C153026981 @default.
• W3046207932 hasConcept C18903297 @default.

• next