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• W3046208148 endingPage "2445" @default.
• W3046208148 startingPage "2445" @default.
• W3046208148 abstract "Sarcoidosis is a systemic, granulomatous, and noninfectious disease of unknown etiology. The clinical heterogeneity of the disease (targeted tissue(s), course of the disease, and therapy response) supports the idea that a multiplicity of trigger antigens may be involved. The pathogenesis of sarcoidosis is not yet completely understood, although in recent years, considerable efforts were put to develop novel experimental research models of sarcoidosis. In particular, sarcoidosis patient cells were used within in vitro 3D models to study their characteristics compared to control patients. Likewise, a series of transgenic mouse models were developed to highlight the role of particular signaling pathways in granuloma formation and persistence. The purpose of this review is to put in perspective the contributions of the most recent models in the understanding of sarcoidosis." @default.
• W3046208148 created "2020-08-03" @default.
• W3046208148 creator A5019589750 @default.
• W3046208148 creator A5055564924 @default.
• W3046208148 date "2020-07-31" @default.
• W3046208148 modified "2023-10-16" @default.
• W3046208148 title "Models Contribution to the Understanding of Sarcoidosis Pathogenesis: “Are There Good Models of Sarcoidosis?”" @default.
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