FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046215166> ?p ?o ?g. }

• W3046215166 endingPage "1800" @default.
• W3046215166 startingPage "1800" @default.
• W3046215166 abstract "Cytosolic calcium (Ca2+) transients control key neural processes, including neurogenesis, migration, the polarization and growth of neurons, and the establishment and maintenance of synaptic connections. They are thus involved in the development and formation of the neural system. In this study, a publicly available whole transcriptome sequencing (RNA-Seq) dataset was used to examine the expression of genes coding for putative plasma membrane and organellar Ca2+-transporting proteins (channels, pumps, exchangers, and transporters) during the formation of the cerebral cortex in mice. Four ages were considered: embryonic days 11 (E11), 13 (E13), and 17 (E17), and post-natal day 1 (PN1). This transcriptomic profiling was also combined with live-cell Ca2+ imaging recordings to assess the presence of functional Ca2+ transport systems in E13 neurons. The most important Ca2+ routes of the cortical wall at the onset of corticogenesis (E11–E13) were TACAN, GluK5, nAChR β2, Cav3.1, Orai3, transient receptor potential cation channel subfamily M member 7 (TRPM7) non-mitochondrial Na+/Ca2+ exchanger 2 (NCX2), and the connexins CX43/CX45/CX37. Hence, transient receptor potential cation channel mucolipin subfamily member 1 (TRPML1), transmembrane protein 165 (TMEM165), and Ca2+ “leak” channels are prominent intracellular Ca2+ pathways. The Ca2+ pumps sarco/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) and plasma membrane Ca2+ ATPase 1 (PMCA1) control the resting basal Ca2+ levels. At the end of neurogenesis (E17 and onward), a more numerous and diverse population of Ca2+ uptake systems was observed. In addition to the actors listed above, prominent Ca2+-conducting systems of the cortical wall emerged, including acid-sensing ion channel 1 (ASIC1), Orai2, P2X2, and GluN1. Altogether, this study provides a detailed view of the pattern of expression of the main actors participating in the import, export, and release of Ca2+. This work can serve as a framework for further functional and mechanistic studies on Ca2+ signaling during cerebral cortex formation." @default.
• W3046215166 created "2020-08-03" @default.
• W3046215166 creator A5000876359 @default.
• W3046215166 date "2020-07-29" @default.
• W3046215166 modified "2023-10-16" @default.
• W3046215166 title "Transcriptomic Profiling of Ca2+ Transport Systems during the Formation of the Cerebral Cortex in Mice" @default.
• W3046215166 cites W1562922081 @default.
• W3046215166 cites W1567439183 @default.
• W3046215166 cites W1567917794 @default.
• W3046215166 cites W1570910223 @default.
• W3046215166 cites W1575476642 @default.
• W3046215166 cites W1585238593 @default.
• W3046215166 cites W1595557903 @default.
• W3046215166 cites W1599277155 @default.
• W3046215166 cites W1608349175 @default.
• W3046215166 cites W1784414891 @default.
• W3046215166 cites W1827209814 @default.
• W3046215166 cites W1934528477 @default.
• W3046215166 cites W1965011883 @default.
• W3046215166 cites W1967099353 @default.
• W3046215166 cites W1967476518 @default.
• W3046215166 cites W1972781757 @default.
• W3046215166 cites W1975307992 @default.
• W3046215166 cites W1979386418 @default.
• W3046215166 cites W1996293616 @default.
• W3046215166 cites W1999770380 @default.
• W3046215166 cites W1999911038 @default.
• W3046215166 cites W1999920289 @default.
• W3046215166 cites W2000046455 @default.
• W3046215166 cites W2002791298 @default.
• W3046215166 cites W2005243425 @default.
• W3046215166 cites W2006339817 @default.
• W3046215166 cites W2009767792 @default.
• W3046215166 cites W2010651242 @default.
• W3046215166 cites W2014520825 @default.
• W3046215166 cites W2017612052 @default.
• W3046215166 cites W2025718532 @default.
• W3046215166 cites W2028690513 @default.
• W3046215166 cites W2030714294 @default.
• W3046215166 cites W2031878500 @default.
• W3046215166 cites W2034012085 @default.
• W3046215166 cites W2036021978 @default.
• W3046215166 cites W2037341321 @default.
• W3046215166 cites W2043330139 @default.
• W3046215166 cites W2046962705 @default.
• W3046215166 cites W2050766695 @default.
• W3046215166 cites W2054843536 @default.
• W3046215166 cites W2058697507 @default.
• W3046215166 cites W2059052368 @default.
• W3046215166 cites W205915804 @default.
• W3046215166 cites W2061603242 @default.
• W3046215166 cites W2063535351 @default.
• W3046215166 cites W2065169750 @default.
• W3046215166 cites W2067128597 @default.
• W3046215166 cites W2067609194 @default.
• W3046215166 cites W2068016566 @default.
• W3046215166 cites W2073006026 @default.
• W3046215166 cites W2075230686 @default.
• W3046215166 cites W2075684020 @default.
• W3046215166 cites W2085722350 @default.
• W3046215166 cites W2086767991 @default.
• W3046215166 cites W2089040449 @default.
• W3046215166 cites W2090863969 @default.
• W3046215166 cites W2098936081 @default.
• W3046215166 cites W2108191968 @default.
• W3046215166 cites W2112984905 @default.
• W3046215166 cites W2114637214 @default.
• W3046215166 cites W2117761303 @default.
• W3046215166 cites W2122071004 @default.
• W3046215166 cites W2127771205 @default.
• W3046215166 cites W2129558481 @default.
• W3046215166 cites W2132295821 @default.
• W3046215166 cites W2138304538 @default.
• W3046215166 cites W2142826449 @default.
• W3046215166 cites W2148761780 @default.
• W3046215166 cites W2151200090 @default.
• W3046215166 cites W2159051287 @default.
• W3046215166 cites W2160908468 @default.
• W3046215166 cites W2162829843 @default.
• W3046215166 cites W2169635583 @default.
• W3046215166 cites W2172000561 @default.
• W3046215166 cites W2177607125 @default.
• W3046215166 cites W2199978366 @default.
• W3046215166 cites W2335818909 @default.
• W3046215166 cites W2337698774 @default.
• W3046215166 cites W2406096232 @default.
• W3046215166 cites W2414393060 @default.
• W3046215166 cites W2513779190 @default.
• W3046215166 cites W2522174175 @default.
• W3046215166 cites W2571514883 @default.
• W3046215166 cites W2581339933 @default.
• W3046215166 cites W2621313755 @default.
• W3046215166 cites W2726302991 @default.
• W3046215166 cites W2735389358 @default.
• W3046215166 cites W2761812283 @default.
• W3046215166 cites W2796462843 @default.
• W3046215166 cites W2809367045 @default.
• W3046215166 cites W2885142817 @default.

• next