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- W3046227589 abstract "Abstract The discovery in the late 1990s of the partnership between the RET receptor tyrosine kinase and the GFRα family of GPI-anchored co-receptors as mediators of the effects of GDNF family ligands galvanized the field of neurotrophic factors, firmly establishing a new molecular framework besides the ubiquitous neurotrophins. Soon after, however, it was realized that many neurons and brain areas expressed GFRα receptors without expressing RET. These observations led to the formulation of two new concepts in GDNF family signaling, namely, the non-cell-autonomous functions of GFRα molecules, so-called trans signaling, as well as cell-autonomous functions mediated by signaling receptors distinct from RET, which became known as RET-independent signaling. To date, the best studied RET-independent signaling pathway for GDNF family ligands involves the neural cell adhesion molecule NCAM and its association with GFRα co-receptors. Among the many functions attributed to this signaling system are neuronal migration, neurite outgrowth, dendrite branching, spine formation, and synaptogenesis. This review summarizes our current understanding of this and other mechanisms of RET-independent signaling by GDNF family ligands and GFRα receptors, as well as their physiological importance." @default.
- W3046227589 created "2020-08-07" @default.
- W3046227589 creator A5038900063 @default.
- W3046227589 creator A5048408581 @default.
- W3046227589 creator A5055040328 @default.
- W3046227589 date "2020-07-31" @default.
- W3046227589 modified "2023-10-13" @default.
- W3046227589 title "RET-independent signaling by GDNF ligands and GFRα receptors" @default.
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- W3046227589 doi "https://doi.org/10.1007/s00441-020-03261-2" @default.
- W3046227589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7529620" @default.
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- W3046227589 hasPublicationYear "2020" @default.
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