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• W3046248967 endingPage "1021" @default.
• W3046248967 startingPage "1009" @default.
• W3046248967 abstract "Regulation of gene expression by the act of noncoding transcription may connect environmental sensing and regulation in eukaryotes. The act of lncRNA transcription affects DNA biology. Intragenic ncDNA elements regulate host gene expression by a variety of mechanisms, including repression, activation and transcript isoform selection. Termination of RNAPII transcription represents a key step in transcriptional regulation tightly linked to noncoding transcription. RNA polymerase (RNAP)II frequently transcribes non-protein-coding DNA sequences in eukaryotic genomes into long noncoding RNA (lncRNA). Distinct molecular mechanisms linked to the position of lncRNA relative to the coding gene illustrate how noncoding transcription controls gene expression. Here, we focus on the impact of the act of lncRNA transcription on nearby functional DNA units. We review the biological significance of the act of lncRNA transcription on DNA processing, highlighting common themes, such as mediating cellular responses to environmental changes. This review combines the background of chromatin signaling with examples in several organisms to clarify when functions of ncDNA can be interpreted through the act of RNAPII transcription. RNA polymerase (RNAP)II frequently transcribes non-protein-coding DNA sequences in eukaryotic genomes into long noncoding RNA (lncRNA). Distinct molecular mechanisms linked to the position of lncRNA relative to the coding gene illustrate how noncoding transcription controls gene expression. Here, we focus on the impact of the act of lncRNA transcription on nearby functional DNA units. We review the biological significance of the act of lncRNA transcription on DNA processing, highlighting common themes, such as mediating cellular responses to environmental changes. This review combines the background of chromatin signaling with examples in several organisms to clarify when functions of ncDNA can be interpreted through the act of RNAPII transcription. regulatory mechanism operating by premature termination of transcription to cause a reduction in gene expression. spatial organization of chromatin in a nucleus. fused transcript resulting from intervening transcription from an upstream transcript into the downstream ORF. uncharacterized RNA transcripts of RNAPII subjected to rapid nuclear degradation. all the molecular and biochemical events that act on DNA. short genomic regions that facilitate the binding of regulatory proteins to increase the transcription of an associated gene. Enhancers can be located far away upstream or downstream (intergenic) or on the same associated gene (intragenic). biochemical process that marks the parental origin of epigenetic information. protein complex that interacts with histone proteins and regulates nucleosome assembly. independent transcription occurring within the annotated region of a gene producing intragenic RNAs. technique to analyze the DNA–protein interactions in a cell at a given time point. RNA transcript attached to RNA polymerase during the act of transcription. molecular process involving the spliceosome complex in the removal of intragenic and noncoding sequences (introns) from primary RNA transcripts. proteins involved in activating or repressing the transcription machinery for gene expression." @default.
• W3046248967 created "2020-08-07" @default.
• W3046248967 creator A5019894528 @default.
• W3046248967 creator A5021083056 @default.
• W3046248967 creator A5032181080 @default.
• W3046248967 creator A5062281397 @default.
• W3046248967 creator A5090744698 @default.
• W3046248967 date "2020-12-01" @default.
• W3046248967 modified "2023-09-23" @default.
• W3046248967 title "DNA Processing in the Context of Noncoding Transcription" @default.
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