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• W3046257645 endingPage "1958" @default.
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• W3046257645 abstract "Abstract NK1.1 + cells found in salivary glands (SG) represent a unique cell population of innate lymphoid cells (ILC) with characteristics of both conventional NK cells and ILC1. Here, we demonstrate that these NK1.1 + cells limit the accumulation and differentiation of virus‐specific tissue‐resident memory CD8 + T cells (T RM cells) in SG of mice infected with lymphocytic choriomeningitis virus (LCMV). The negative regulation of LCMV‐specific CD8 + T RM cells by NK1.1 + cells in SG is independent of NKG2D, NKp46, TRAIL, and perforin. Moreover, analysis of NKp46 iCre+ Eomes fl/fl mice revealed that Eomes‐dependent conventional NK cells are dispensable for negative regulation. Since the SG are prone to autoimmune reactions, regulation of T RM cells by tissue‐resident ILC may be particularly important to prevent immunopathology in this organ." @default.
• W3046257645 created "2020-08-07" @default.
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• W3046257645 date "2020-08-17" @default.
• W3046257645 modified "2023-10-18" @default.
• W3046257645 title "NK1.1 ⁺ innate lymphoid cells in salivary glands inhibit establishment of tissue‐resident memory CD8 ⁺ T cells in mice" @default.
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• W3046257645 doi "https://doi.org/10.1002/eji.202048741" @default.
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