Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046271858> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W3046271858 abstract "Introduction Identification of Crohn’s disease (CD) patients who require early biological and immunosuppressive therapy is essential to target therapy appropriately (1). Clinical predictors of disabling behaviour may point towards early aggressive medical therapy but some of these may not be apparent at diagnosis. Mesenteric fat index (MFI) has been previously shown to predict a complicated disease course in CD (2). In this study, we examined the utility of MFI and other clinical factors in predicting the need for biological and immunosuppressive therapy in CD. Method In this retrospective single centre study, we identified therapy naive CD patients who underwent cross sectional imaging at diagnosis at the Royal Liverpool University Hospital between 2005 and 2015. MFI was calculated using previously described methods. Clinical details and need for biological, immunosuppressive and combination therapy was abstracted from the case notes. A logistic regression model was used to examine the utility of clinical factors including MFI in predicting the need for immunosuppressive, biological and combination therapy. Results A total of 81 patients were included in the study. In a multivariate model, steroids at diagnosis was associated with the need for subsequent immunosuppressive (Odds ratio, OR, 8.0, 95% CI 1.3–51, p=0.027), anti-TNF (OR 4.3, 95% CI, 1.2–16.5, p=0.029) and combination therapy (OR 3.8, 95% CI, 1.1–13.9, p=0.041). Deep ulcers on colonoscopy was associated with the need for subsequent anti-TNF therapy (OR 14.9, 95% CI, 1.1–209.2, p=0.045) but not immunosuppressive or combination therapy. MFI was not significantly associated with the need for subsequent immunosupression, biological or combination therapy. Conclusion Steroids at diagnosis but not MFI predicted the need for subsequent immunosupressive, anti-TNF and combination therapy. Presence of deep ulceration at index colonoscopy was associated with the need for subsequent anti-TNF therapy. Clinicians should consider patients with these characteristics for early aggressive medical therapy. References . D’Haens G, Baert F, van Assche G, et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial. Lancet Lond Engl. 2008Feb 23;371(9613):660–7. doi: 10.1016/S0140-6736(08)60304-9 . Erhayiem B, Dhingsa R, Hawkey CJ, Subramanian V. Ratio of Visceral to Subcutaneous Fat Area Is a Biomarker of Complicated Crohn’s Disease. Clin Gastroenterol Hepatol. 2011Aug;9(8):684–7.e1. doi: 10.1016/j.cgh.2011.05.005 Disclosure of Interest None Declared" @default.
- W3046271858 created "2020-08-07" @default.
- W3046271858 creator A5010149242 @default.
- W3046271858 creator A5010361101 @default.
- W3046271858 creator A5056968218 @default.
- W3046271858 creator A5076213475 @default.
- W3046271858 creator A5085613552 @default.
- W3046271858 creator A5087654725 @default.
- W3046271858 date "2017-07-01" @default.
- W3046271858 modified "2023-09-26" @default.
- W3046271858 title "PTH-080 Steroids at diagnosis but not mesenteric fat index predicts the need for biologic therapy in treatment naÏve crohn’s diseasepatients: a retrospective cohort study" @default.
- W3046271858 doi "https://doi.org/10.1136/gutjnl-2017-314472.479" @default.
- W3046271858 hasPublicationYear "2017" @default.
- W3046271858 type Work @default.
- W3046271858 sameAs 3046271858 @default.
- W3046271858 citedByCount "0" @default.
- W3046271858 crossrefType "journal-article" @default.
- W3046271858 hasAuthorship W3046271858A5010149242 @default.
- W3046271858 hasAuthorship W3046271858A5010361101 @default.
- W3046271858 hasAuthorship W3046271858A5056968218 @default.
- W3046271858 hasAuthorship W3046271858A5076213475 @default.
- W3046271858 hasAuthorship W3046271858A5085613552 @default.
- W3046271858 hasAuthorship W3046271858A5087654725 @default.
- W3046271858 hasConcept C121608353 @default.
- W3046271858 hasConcept C126322002 @default.
- W3046271858 hasConcept C151956035 @default.
- W3046271858 hasConcept C156957248 @default.
- W3046271858 hasConcept C167135981 @default.
- W3046271858 hasConcept C2776999253 @default.
- W3046271858 hasConcept C2778435480 @default.
- W3046271858 hasConcept C2779134260 @default.
- W3046271858 hasConcept C2779280984 @default.
- W3046271858 hasConcept C38180746 @default.
- W3046271858 hasConcept C526805850 @default.
- W3046271858 hasConcept C71924100 @default.
- W3046271858 hasConcept C90924648 @default.
- W3046271858 hasConceptScore W3046271858C121608353 @default.
- W3046271858 hasConceptScore W3046271858C126322002 @default.
- W3046271858 hasConceptScore W3046271858C151956035 @default.
- W3046271858 hasConceptScore W3046271858C156957248 @default.
- W3046271858 hasConceptScore W3046271858C167135981 @default.
- W3046271858 hasConceptScore W3046271858C2776999253 @default.
- W3046271858 hasConceptScore W3046271858C2778435480 @default.
- W3046271858 hasConceptScore W3046271858C2779134260 @default.
- W3046271858 hasConceptScore W3046271858C2779280984 @default.
- W3046271858 hasConceptScore W3046271858C38180746 @default.
- W3046271858 hasConceptScore W3046271858C526805850 @default.
- W3046271858 hasConceptScore W3046271858C71924100 @default.
- W3046271858 hasConceptScore W3046271858C90924648 @default.
- W3046271858 hasLocation W30462718581 @default.
- W3046271858 hasOpenAccess W3046271858 @default.
- W3046271858 hasPrimaryLocation W30462718581 @default.
- W3046271858 hasVolume "66" @default.
- W3046271858 isParatext "false" @default.
- W3046271858 isRetracted "false" @default.
- W3046271858 magId "3046271858" @default.
- W3046271858 workType "article" @default.