FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046308652> ?p ?o ?g. }

• W3046308652 endingPage "1030" @default.
• W3046308652 startingPage "1029.2" @default.
• W3046308652 abstract "Background: Therapeutic apheresis (TA) represents a therapeutic option in pre-existing conditions or rheumatic diseases that occur during gestation. Although pregnancy is not a contraindication itself, due to the lack of evidence-based guidelines and the alleged risk of maternal and/or fetal adverse events, there is general resistance to its application during pregnancy. Objectives: In this observational study we aimed to evaluate the efficacy and safety of TA in high-risk pregnancies in patients with rheumatic diseases, followed over a decade in a tertiary Center. Methods: Between January 2005 and April 2019, 843 TA procedures were performed during 51 pregnancies in 43 patients: 745 plasma exchange sessions and 98 immunoabsorption sessions. TA was performed in 29 (57%) pregnancies of 21 (48.8%) patients with antiphospholipid antibody syndrome (APS), in 20 (39.2%) pregnancies of 20 (46.5%) patients with congenital heart block (CHB), in 1 (1.9%) pregnancy of 1 (2.3%) patient with systemic sclerosis (SSc) and 1 (1.9%) pregnancy of 1 (2.3%) patient affected by lupic nephritis (SLE). Results: During the period considered, apheresis sessions applied to pregnant women were 7.1% of the total (n = 13.251). The average age at the first treatment was 33 years (range 24-43). The mean management age at the first apheretic treatment was 21 weeks (range 4-32). Twelve (1.4%) apheresis sessions were complicated by adverse events, none required or prolonged hospitalization. There were 44 (86.3%) live births, 3 (5.9%) spontaneous abortions and 2 (3.9%) voluntary terminations of pregnancy, 2 (3.9%) lost to follow-up. The average gestational age at birth was 35 weeks (range 24-37) and cesarean section was performed in 41 (80.4%) cases. TA was added to conventional therapy in 24/29 (82.7%) patients with APS, to the detection of fetal cardiac activity, while in 5/26 (17.3%) it was introduced when the first signs of pregnancy complications such as mild preclampsia, HELLP and IUGR were detected. TA was started within 24 hours of atrioventricular block (AVB) detection; 10/20 (50%) mothers with CHB were diagnosed with 2nd degree AVB, 9/20 (45%) with 3rd degree AVB and one (5%) with sinus bradycardia and endocardial fibroelastosis. The patient with SSc was treated with TA twice a week from the 32nd SG until delivery, which occurred at the 36th SG, due to severe IUGR and oligohydramnios. The patient with SLE complicated by lupic nephritis was treated with TA twice a week, from the 26th SG until the birth, which took place at the 31st SG. Conclusion: Our data have shown that TA in pregnancy is well tolerated. Close collaboration between rheumatologist, obstetrician and specialist in TA is essential to ensure a successful outcome of high-risk pregnancies. Disclosure of Interests: : Anna Colpo: None declared, Piero Marson: None declared, Tiziana Tison: None declared, Alessandra Zambon: None declared, Annalisa La Rosa: None declared, Ermella Zanetti: None declared, Amelia Ruffatti: None declared, Giustina De Silvestro: None declared, Ariela Hoxha Speakers bureau: Celgene, UCB, Novartis, Sanofi, Werfen" @default.
• W3046308652 created "2020-08-07" @default.
• W3046308652 creator A5011685653 @default.
• W3046308652 creator A5017797125 @default.
• W3046308652 creator A5049570042 @default.
• W3046308652 creator A5054501484 @default.
• W3046308652 creator A5082334430 @default.
• W3046308652 creator A5084614837 @default.
• W3046308652 creator A5085761102 @default.
• W3046308652 creator A5086285478 @default.
• W3046308652 creator A5087432225 @default.
• W3046308652 date "2020-06-01" @default.
• W3046308652 modified "2023-10-16" @default.
• W3046308652 title "SAT0176 THERAPEUTIC APHERESIS DURING PREGNANCY IN RHEUMATIC DISEASES" @default.
• W3046308652 doi "https://doi.org/10.1136/annrheumdis-2020-eular.3939" @default.
• W3046308652 hasPublicationYear "2020" @default.
• W3046308652 type Work @default.
• W3046308652 sameAs 3046308652 @default.
• W3046308652 citedByCount "0" @default.
• W3046308652 crossrefType "journal-article" @default.
• W3046308652 hasAuthorship W3046308652A5011685653 @default.
• W3046308652 hasAuthorship W3046308652A5017797125 @default.
• W3046308652 hasAuthorship W3046308652A5049570042 @default.
• W3046308652 hasAuthorship W3046308652A5054501484 @default.
• W3046308652 hasAuthorship W3046308652A5082334430 @default.
• W3046308652 hasAuthorship W3046308652A5084614837 @default.
• W3046308652 hasAuthorship W3046308652A5085761102 @default.
• W3046308652 hasAuthorship W3046308652A5086285478 @default.
• W3046308652 hasAuthorship W3046308652A5087432225 @default.
• W3046308652 hasBestOaLocation W30463086521 @default.
• W3046308652 hasConcept C126322002 @default.
• W3046308652 hasConcept C131872663 @default.
• W3046308652 hasConcept C142724271 @default.
• W3046308652 hasConcept C187212893 @default.
• W3046308652 hasConcept C197934379 @default.
• W3046308652 hasConcept C204787440 @default.
• W3046308652 hasConcept C2776494729 @default.
• W3046308652 hasConcept C2776738589 @default.
• W3046308652 hasConcept C2776874634 @default.
• W3046308652 hasConcept C2779234561 @default.
• W3046308652 hasConcept C2780868729 @default.
• W3046308652 hasConcept C46973012 @default.
• W3046308652 hasConcept C54355233 @default.
• W3046308652 hasConcept C71924100 @default.
• W3046308652 hasConcept C86803240 @default.
• W3046308652 hasConcept C89560881 @default.
• W3046308652 hasConceptScore W3046308652C126322002 @default.
• W3046308652 hasConceptScore W3046308652C131872663 @default.
• W3046308652 hasConceptScore W3046308652C142724271 @default.
• W3046308652 hasConceptScore W3046308652C187212893 @default.
• W3046308652 hasConceptScore W3046308652C197934379 @default.
• W3046308652 hasConceptScore W3046308652C204787440 @default.
• W3046308652 hasConceptScore W3046308652C2776494729 @default.
• W3046308652 hasConceptScore W3046308652C2776738589 @default.
• W3046308652 hasConceptScore W3046308652C2776874634 @default.
• W3046308652 hasConceptScore W3046308652C2779234561 @default.
• W3046308652 hasConceptScore W3046308652C2780868729 @default.
• W3046308652 hasConceptScore W3046308652C46973012 @default.
• W3046308652 hasConceptScore W3046308652C54355233 @default.
• W3046308652 hasConceptScore W3046308652C71924100 @default.
• W3046308652 hasConceptScore W3046308652C86803240 @default.
• W3046308652 hasConceptScore W3046308652C89560881 @default.
• W3046308652 hasIssue "Suppl 1" @default.
• W3046308652 hasLocation W30463086521 @default.
• W3046308652 hasOpenAccess W3046308652 @default.
• W3046308652 hasPrimaryLocation W30463086521 @default.
• W3046308652 hasRelatedWork W2092207023 @default.
• W3046308652 hasRelatedWork W2175122158 @default.
• W3046308652 hasRelatedWork W2186200056 @default.
• W3046308652 hasRelatedWork W2330636117 @default.
• W3046308652 hasRelatedWork W2409168192 @default.
• W3046308652 hasRelatedWork W3046308652 @default.
• W3046308652 hasRelatedWork W4200420510 @default.
• W3046308652 hasRelatedWork W4224607730 @default.
• W3046308652 hasRelatedWork W4281694272 @default.
• W3046308652 hasRelatedWork W985205842 @default.
• W3046308652 hasVolume "79" @default.
• W3046308652 isParatext "false" @default.
• W3046308652 isRetracted "false" @default.
• W3046308652 magId "3046308652" @default.
• W3046308652 workType "article" @default.