FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046337317> ?p ?o ?g. }

• W3046337317 endingPage "165908" @default.
• W3046337317 startingPage "165908" @default.
• W3046337317 abstract "Circadian misalignment induced by a high-fat diet (HFD) increases the risk of metabolic diseases. Methionine restriction (MR) is known to have the potential of alleviating obesity by improving insulin sensitivity. However, the role of the circadian clock in mediating the effects of MR on obesity-related metabolic disorders remains unclear. Ten-week-old male C57BL/6 J mice were fed with a low-fat diet (LFD) or a HFD for 4 wk., followed with a full diet (0.86% methionine, w / w ) or a methionine-restricted diet (0.17% methionine, w / w ) for 8 wk. Our results showed that MR attenuated insulin resistance triggered by HFD, especially at ZT12. Moreover, MR led to a time-specific enhancement of the expression of FGF21 and activated the AMPK/PGC-1α signaling. Notably, MR upregulated the cyclical levels of cholic acid (CA) and chenodeoxycholic acid (CDCA), and downregulated the cyclical level of deoxycholic acid (DCA) in the dark phase. MR restored the HFD-disrupted cyclical fluctuations of lipidolysis genes and BAs synthetic genes and improved the circulating lipid profile. Also, MR improved the expressions of clock-controlled genes (CCGs) in the liver and the brown adipose tissue throughout one day. In conclusion, MR exhibited the lipid-lowering effects on HFD-induced obesity and restored the diurnal metabolism of lipids and BAs, which could be partly explained by improving the expression of CCGs. These findings suggested that MR could be a potential nutritional intervention for attenuating obesity-induced metabolic misalignment. Methionine restriction led to time-specific improvement in insulin sensitivity, enhanced diurnal expressions of FGF21 and clock-controlled genes, and restored cyclical metabolism of lipids and bile acids in high-fat diet-fed mice. • MR led to time-specific improvement of insulin sensitivity. • MR enhanced the diurnal expression of FGF21 and inhibited lipid accumulation. • MR restored the cyclical fluctuations of the metabolism of lipids and BAs in obese mice. • MR improved the expressions of CCGs in the liver and the BAT." @default.
• W3046337317 created "2020-08-07" @default.
• W3046337317 creator A5010530965 @default.
• W3046337317 creator A5011660345 @default.
• W3046337317 creator A5029551526 @default.
• W3046337317 creator A5031996868 @default.
• W3046337317 creator A5039522571 @default.
• W3046337317 creator A5050251296 @default.
• W3046337317 creator A5052441498 @default.
• W3046337317 creator A5071495688 @default.
• W3046337317 creator A5085951723 @default.
• W3046337317 date "2020-11-01" @default.
• W3046337317 modified "2023-10-16" @default.
• W3046337317 title "Methionine restriction alleviates high-fat diet-induced obesity: Involvement of diurnal metabolism of lipids and bile acids" @default.
• W3046337317 cites W1507277641 @default.
• W3046337317 cites W1590993351 @default.
• W3046337317 cites W1966181749 @default.
• W3046337317 cites W1966922165 @default.
• W3046337317 cites W1973686253 @default.
• W3046337317 cites W1982042514 @default.
• W3046337317 cites W1992726958 @default.
• W3046337317 cites W1993901564 @default.
• W3046337317 cites W1996333896 @default.
• W3046337317 cites W1996482353 @default.
• W3046337317 cites W1996559176 @default.
• W3046337317 cites W1997151200 @default.
• W3046337317 cites W1998970086 @default.
• W3046337317 cites W2003302378 @default.
• W3046337317 cites W2011072921 @default.
• W3046337317 cites W2011131953 @default.
• W3046337317 cites W2026360229 @default.
• W3046337317 cites W2026930722 @default.
• W3046337317 cites W2029477556 @default.
• W3046337317 cites W2039466176 @default.
• W3046337317 cites W2044458189 @default.
• W3046337317 cites W2052225210 @default.
• W3046337317 cites W2056395995 @default.
• W3046337317 cites W2075783271 @default.
• W3046337317 cites W2079580613 @default.
• W3046337317 cites W2082498929 @default.
• W3046337317 cites W2089814579 @default.
• W3046337317 cites W2102459969 @default.
• W3046337317 cites W2105162154 @default.
• W3046337317 cites W2112291880 @default.
• W3046337317 cites W2116604343 @default.
• W3046337317 cites W2119649463 @default.
• W3046337317 cites W2121051938 @default.
• W3046337317 cites W2123319274 @default.
• W3046337317 cites W2123561714 @default.
• W3046337317 cites W2126188293 @default.
• W3046337317 cites W2126761533 @default.
• W3046337317 cites W2131622156 @default.
• W3046337317 cites W2134778685 @default.
• W3046337317 cites W2140968650 @default.
• W3046337317 cites W2149348167 @default.
• W3046337317 cites W2165852917 @default.
• W3046337317 cites W2290830937 @default.
• W3046337317 cites W2346592443 @default.
• W3046337317 cites W2347332048 @default.
• W3046337317 cites W2428595929 @default.
• W3046337317 cites W2460041770 @default.
• W3046337317 cites W2567503091 @default.
• W3046337317 cites W2588251211 @default.
• W3046337317 cites W2605280287 @default.
• W3046337317 cites W2605574079 @default.
• W3046337317 cites W2608486237 @default.
• W3046337317 cites W2746476900 @default.
• W3046337317 cites W2751357806 @default.
• W3046337317 cites W2762103120 @default.
• W3046337317 cites W2795135362 @default.
• W3046337317 cites W2799463911 @default.
• W3046337317 cites W2809281217 @default.
• W3046337317 cites W2883902554 @default.
• W3046337317 cites W2888868369 @default.
• W3046337317 cites W2889094742 @default.
• W3046337317 cites W2900533762 @default.
• W3046337317 cites W2904447327 @default.
• W3046337317 cites W2905294359 @default.
• W3046337317 cites W2912766252 @default.
• W3046337317 cites W2914171609 @default.
• W3046337317 cites W2918457879 @default.
• W3046337317 cites W2934548326 @default.
• W3046337317 cites W2939866782 @default.
• W3046337317 cites W2948077500 @default.
• W3046337317 cites W2949260941 @default.
• W3046337317 cites W2949668662 @default.
• W3046337317 cites W2953324747 @default.
• W3046337317 cites W2964871068 @default.
• W3046337317 cites W2972936715 @default.
• W3046337317 cites W2978364603 @default.
• W3046337317 cites W2982480446 @default.
• W3046337317 cites W2982531730 @default.
• W3046337317 cites W588563159 @default.
• W3046337317 doi "https://doi.org/10.1016/j.bbadis.2020.165908" @default.
• W3046337317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32745530" @default.
• W3046337317 hasPublicationYear "2020" @default.
• W3046337317 type Work @default.
• W3046337317 sameAs 3046337317 @default.

• next