FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046355705> ?p ?o ?g. }

• W3046355705 abstract "Colon cancer is one of the most commonly diagnosed cancers worldwide. Both environmental and molecular characters can influence its development. DNA methylation has been heralded as a promising marker for use in cancer prevention, diagnosis, and treatment. It has been shown to facilitate cancer progression through multiple mechanisms. Changes in DNA methylation can inhibit or promote the binding of transcription factors (TFs) and further disturb gene regulation. Detection DNA methylation-mediated regulatory events in colon cancer are critical for mining novel biomarkers. Here, we explore the influence of CpG sites located at promoter regions of differentially expressed genes and identify methylation–gene relationships using expression–methylation quantitative trait loci. We find that promoter methylation sites mainly negatively regulate the corresponding genes. We also identify candidate TFs that can bind to these sites in a sequence-dependent manner. By integrating transcriptome and methylome profiles, we construct a TF–CpG–gene regulatory network for colon cancer, which is used to determine the roles of TFs and methylation in the transcription process. Finally, based on TF–CpG–gene relationships, we design a framework to evaluate patient prognosis, which shows that one TF–CpG–gene triplet is significantly associated with patient survival rate and represents a potential novel biomarker for use in colon cancer prognosis and treatment." @default.
• W3046355705 created "2020-08-07" @default.
• W3046355705 creator A5000940583 @default.
• W3046355705 creator A5003934555 @default.
• W3046355705 creator A5029730039 @default.
• W3046355705 creator A5034995105 @default.
• W3046355705 creator A5057793246 @default.
• W3046355705 creator A5060009543 @default.
• W3046355705 creator A5064550005 @default.
• W3046355705 date "2020-07-31" @default.
• W3046355705 modified "2023-09-27" @default.
• W3046355705 title "Identification of Transcription Factor/Gene Axis in Colon Cancer Using a Methylome Approach" @default.
• W3046355705 cites W1572687140 @default.
• W3046355705 cites W1607026529 @default.
• W3046355705 cites W1709815505 @default.
• W3046355705 cites W1983484637 @default.
• W3046355705 cites W1987894088 @default.
• W3046355705 cites W2015705446 @default.
• W3046355705 cites W2024227785 @default.
• W3046355705 cites W2025597434 @default.
• W3046355705 cites W2029632256 @default.
• W3046355705 cites W2041686632 @default.
• W3046355705 cites W2062190843 @default.
• W3046355705 cites W2066941077 @default.
• W3046355705 cites W2075107349 @default.
• W3046355705 cites W2076814413 @default.
• W3046355705 cites W2076865561 @default.
• W3046355705 cites W2082367829 @default.
• W3046355705 cites W2113676327 @default.
• W3046355705 cites W2131050852 @default.
• W3046355705 cites W2135056923 @default.
• W3046355705 cites W2136430672 @default.
• W3046355705 cites W2140952049 @default.
• W3046355705 cites W2171552768 @default.
• W3046355705 cites W2230320310 @default.
• W3046355705 cites W2663574681 @default.
• W3046355705 cites W2766526974 @default.
• W3046355705 cites W2767056811 @default.
• W3046355705 cites W2770182290 @default.
• W3046355705 cites W2795382323 @default.
• W3046355705 cites W2897187982 @default.
• W3046355705 cites W2898598946 @default.
• W3046355705 cites W2903726109 @default.
• W3046355705 cites W2969382515 @default.
• W3046355705 cites W2990086739 @default.
• W3046355705 doi "https://doi.org/10.3389/fgene.2020.00864" @default.
• W3046355705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7412971" @default.
• W3046355705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32849837" @default.
• W3046355705 hasPublicationYear "2020" @default.
• W3046355705 type Work @default.
• W3046355705 sameAs 3046355705 @default.
• W3046355705 citedByCount "1" @default.
• W3046355705 countsByYear W30463557052022 @default.
• W3046355705 crossrefType "journal-article" @default.
• W3046355705 hasAuthorship W3046355705A5000940583 @default.
• W3046355705 hasAuthorship W3046355705A5003934555 @default.
• W3046355705 hasAuthorship W3046355705A5029730039 @default.
• W3046355705 hasAuthorship W3046355705A5034995105 @default.
• W3046355705 hasAuthorship W3046355705A5057793246 @default.
• W3046355705 hasAuthorship W3046355705A5060009543 @default.
• W3046355705 hasAuthorship W3046355705A5064550005 @default.
• W3046355705 hasBestOaLocation W30463557051 @default.
• W3046355705 hasConcept C101762097 @default.
• W3046355705 hasConcept C104317684 @default.
• W3046355705 hasConcept C121608353 @default.
• W3046355705 hasConcept C140173407 @default.
• W3046355705 hasConcept C150194340 @default.
• W3046355705 hasConcept C165864922 @default.
• W3046355705 hasConcept C190727270 @default.
• W3046355705 hasConcept C33288867 @default.
• W3046355705 hasConcept C3662595 @default.
• W3046355705 hasConcept C502942594 @default.
• W3046355705 hasConcept C526805850 @default.
• W3046355705 hasConcept C54355233 @default.
• W3046355705 hasConcept C70721500 @default.
• W3046355705 hasConcept C86339819 @default.
• W3046355705 hasConcept C86803240 @default.
• W3046355705 hasConceptScore W3046355705C101762097 @default.
• W3046355705 hasConceptScore W3046355705C104317684 @default.
• W3046355705 hasConceptScore W3046355705C121608353 @default.
• W3046355705 hasConceptScore W3046355705C140173407 @default.
• W3046355705 hasConceptScore W3046355705C150194340 @default.
• W3046355705 hasConceptScore W3046355705C165864922 @default.
• W3046355705 hasConceptScore W3046355705C190727270 @default.
• W3046355705 hasConceptScore W3046355705C33288867 @default.
• W3046355705 hasConceptScore W3046355705C3662595 @default.
• W3046355705 hasConceptScore W3046355705C502942594 @default.
• W3046355705 hasConceptScore W3046355705C526805850 @default.
• W3046355705 hasConceptScore W3046355705C54355233 @default.
• W3046355705 hasConceptScore W3046355705C70721500 @default.
• W3046355705 hasConceptScore W3046355705C86339819 @default.
• W3046355705 hasConceptScore W3046355705C86803240 @default.
• W3046355705 hasLocation W30463557051 @default.
• W3046355705 hasLocation W30463557052 @default.
• W3046355705 hasLocation W30463557053 @default.
• W3046355705 hasOpenAccess W3046355705 @default.
• W3046355705 hasPrimaryLocation W30463557051 @default.
• W3046355705 hasRelatedWork W1999023151 @default.
• W3046355705 hasRelatedWork W2014240426 @default.
• W3046355705 hasRelatedWork W2033874367 @default.

• next