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• W3046360811 abstract "Maintaining healthy body weight is increasingly difficult in our obesogenic environment. Dieting efforts are often overpowered by the internal drive to consume energy-dense foods. Although the selection of calorically rich substrates over healthier options is identifiable across species, the mechanisms behind this choice remain poorly understood. Using a passive devaluation paradigm, we found that exposure to high-fat diet (HFD) suppresses the intake of nutritionally balanced standard chow diet (SD) irrespective of age, sex, body mass accrual and functional leptin or melanocortin-4 receptor signaling. Longitudinal recordings revealed that this SD devaluation and subsequent shift toward HFD consumption is encoded at the level of hypothalamic agouti-related peptide neurons and mesolimbic dopamine signaling. Prior HFD consumption vastly diminished the capacity of SD to alleviate the negative valence associated with hunger and the rewarding properties of food discovery even after periods of HFD abstinence. These data reveal a neural basis behind the hardships of dieting. Mazzone and Liang-Guallpa et al. demonstrate that consuming high-fat foods rapidly and durably tunes parallel brain circuits to drive intake of a high-fat diet while devaluing a nutritionally balanced, standard diet even under states of intense hunger." @default.
• W3046360811 created "2020-08-07" @default.
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• W3046360811 date "2020-08-03" @default.
• W3046360811 modified "2023-10-10" @default.
• W3046360811 title "High-fat food biases hypothalamic and mesolimbic expression of consummatory drives" @default.
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• W3046360811 doi "https://doi.org/10.1038/s41593-020-0684-9" @default.
• W3046360811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7529959" @default.
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