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• W3046380072 abstract "Abstract The laboratory rat has been used for a long time as the model of choice in several biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide range of phenotypes and providing many models of human traits and diseases. Rat genome mapping and genomics was considerably developed in the last decades. The availability of these resources has stimulated numerous studies aimed at discovering causal disease genes by positional identification. Numerous rat genes have now been identified that underlie monogenic or complex diseases and remarkably, these results have been translated to the human in a significant proportion of cases, leading to the identification of novel human disease susceptibility genes, helping in studying the mechanisms underlying the pathological abnormalities and also suggesting new therapeutic approaches. In addition, reverse genetic tools have been developed. Several genome-editing methods were introduced to generate targeted mutations in genes the function of which could be clarified in this manner [generally these are knockout mutations]. Furthermore, even when the human gene causing a disease had been identified without resorting to a rat model, mutated rat strains (in particular KO strains) were created to analyze the gene function and the disease pathogenesis. Today, over 350 rat genes have been identified as underlying diseases or playing a key role in critical biological processes that are altered in diseases, thereby providing a rich resource of disease models. This article is an update of the progress made in this research and provides the reader with an inventory of these disease genes, a significant number of which have similar effects in rat and humans." @default.
• W3046380072 created "2020-08-07" @default.
• W3046380072 creator A5067204984 @default.
• W3046380072 date "2020-08-02" @default.
• W3046380072 modified "2023-10-10" @default.
• W3046380072 title "Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes" @default.
• W3046380072 cites W1427793766 @default.
• W3046380072 cites W1481787056 @default.
• W3046380072 cites W1498799134 @default.
• W3046380072 cites W1513280988 @default.
• W3046380072 cites W1555130066 @default.
• W3046380072 cites W1564028006 @default.
• W3046380072 cites W1565230790 @default.
• W3046380072 cites W1586032508 @default.
• W3046380072 cites W1586998625 @default.
• W3046380072 cites W1593139778 @default.
• W3046380072 cites W1596954550 @default.
• W3046380072 cites W1668393390 @default.
• W3046380072 cites W1765019036 @default.
• W3046380072 cites W1797926098 @default.
• W3046380072 cites W1832309913 @default.
• W3046380072 cites W1838763289 @default.
• W3046380072 cites W1861468848 @default.
• W3046380072 cites W1906588918 @default.
• W3046380072 cites W1907802063 @default.
• W3046380072 cites W1908867576 @default.
• W3046380072 cites W1913667543 @default.
• W3046380072 cites W1927036797 @default.
• W3046380072 cites W1932732423 @default.
• W3046380072 cites W1951469632 @default.
• W3046380072 cites W1963497776 @default.
• W3046380072 cites W1963704787 @default.
• W3046380072 cites W1965623265 @default.
• W3046380072 cites W1966198395 @default.
• W3046380072 cites W1966604733 @default.
• W3046380072 cites W1968263694 @default.
• W3046380072 cites W1968844080 @default.
• W3046380072 cites W1968940896 @default.
• W3046380072 cites W1969321137 @default.
• W3046380072 cites W1969977199 @default.
• W3046380072 cites W1971545967 @default.
• W3046380072 cites W1972308058 @default.
• W3046380072 cites W1972519365 @default.
• W3046380072 cites W1974759039 @default.
• W3046380072 cites W1976987687 @default.
• W3046380072 cites W1978142031 @default.
• W3046380072 cites W1978317129 @default.
• W3046380072 cites W1978343601 @default.
• W3046380072 cites W1978368671 @default.
• W3046380072 cites W1978402497 @default.
• W3046380072 cites W1979298921 @default.
• W3046380072 cites W1979675456 @default.
• W3046380072 cites W1979862336 @default.
• W3046380072 cites W1980754624 @default.
• W3046380072 cites W1982115147 @default.
• W3046380072 cites W1982663009 @default.
• W3046380072 cites W1982686720 @default.
• W3046380072 cites W1983110676 @default.
• W3046380072 cites W1983879054 @default.
• W3046380072 cites W1984353621 @default.
• W3046380072 cites W1985433581 @default.
• W3046380072 cites W1987343218 @default.
• W3046380072 cites W1987768765 @default.
• W3046380072 cites W1988377985 @default.
• W3046380072 cites W1990905753 @default.
• W3046380072 cites W1991058523 @default.
• W3046380072 cites W1991774122 @default.
• W3046380072 cites W1991918541 @default.
• W3046380072 cites W1992048305 @default.
• W3046380072 cites W1995842325 @default.
• W3046380072 cites W1996828685 @default.
• W3046380072 cites W1996838055 @default.
• W3046380072 cites W1997285521 @default.
• W3046380072 cites W1997296067 @default.
• W3046380072 cites W1997465995 @default.
• W3046380072 cites W1999034383 @default.
• W3046380072 cites W1999513543 @default.
• W3046380072 cites W1999737827 @default.
• W3046380072 cites W2000114891 @default.
• W3046380072 cites W2001812146 @default.
• W3046380072 cites W2004945792 @default.
• W3046380072 cites W2005697961 @default.
• W3046380072 cites W2006640083 @default.
• W3046380072 cites W2007829567 @default.
• W3046380072 cites W2008203293 @default.
• W3046380072 cites W2009742672 @default.
• W3046380072 cites W2011419513 @default.
• W3046380072 cites W2011477714 @default.
• W3046380072 cites W2012267449 @default.
• W3046380072 cites W2012846440 @default.
• W3046380072 cites W2013224456 @default.
• W3046380072 cites W2016774426 @default.
• W3046380072 cites W2017506029 @default.
• W3046380072 cites W2019212364 @default.
• W3046380072 cites W2019476508 @default.
• W3046380072 cites W2019538882 @default.
• W3046380072 cites W2019562224 @default.
• W3046380072 cites W2019797959 @default.
• W3046380072 cites W2020030808 @default.
• W3046380072 cites W2022002566 @default.

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