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- W3046390805 abstract "Background and objective: Inflammation has been studied for thousands of years in an effort to mitigate its negative effects on the body. Analgesic and anti-inflammatory drugs were the primary concern in monoterpenes. Monoterpenes have been recognized for their ability to suppress inflammatory process and modulate the vital chemical mediators of inflammation, such as pro-inflammatory and anti-inflammatory cytokines. This study aimed to isolate the secondary metabolites of Lantana montevidensis (Verbenaceae) flowers and evaluate their in vitro antiinflammatory activity.Material and methods: Anti-inflammatory activity was done using TNF-α ELISA and NF-κB reporter gene assays.Results and discussion: As a result, seven compounds were isolated and identified, in which three of them were reported for the first time from genus Lantana. For the TNF-α ELISA assay, compound 1 significantly reduced the level of TNF-α (83.5 pg/mL), while compounds 2 and 3 showed moderate inhibition to TNF-α level (144.7 ± 7.43 and146.2 ± 5.27 pg/mL respectively). In addition, the NF-κB reporter gene assay revealed that the tested compounds (1-2) inhibited the relative NF-κB activity which was induced by TNF-α (0.41 ± 0.01 and 0.47 ± 0.01, respectively). Staursporine was used as a positive control in both assays.Conclusion: Linalool glycosides isolated from flowers of L. montevidensis exhibited significant anti-inflammatory activity by reducing the TNF-α level and inhibition of NF-κB pathway." @default.
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- W3046390805 date "2020-01-01" @default.
- W3046390805 modified "2023-09-26" @default.
- W3046390805 title "Linalool Glycosides from Flowers of Lantana montevidensis with Promising AntiInflammatory Potentials" @default.
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