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• W3046391612 endingPage "102370" @default.
• W3046391612 startingPage "102370" @default.
• W3046391612 abstract "Schizophrenia has long been framed as a disorder of altered brain connectivity, with dysfunction in thalamocortical circuity potentially playing a key role in the development of the illness phenotype, including psychotic symptomatology and cognitive impairments. There is emerging evidence for functional and structural hypoconnectivity between thalamus and prefrontal cortex in persons with schizophrenia spectrum disorders, as well as hyperconnectivity between thalamus and sensory and motor cortices. However, it is unclear whether thalamocortical dysconnectivity is a general marker of vulnerability to schizophrenia or a specific mechanism of schizophrenia pathophysiology. This study aimed to answer this question by using diffusion-weighted imaging to examine thalamocortical structural connectivity in 22 persons with schizophrenia or schizoaffective disorder (SZ), 20 siblings of individuals with a schizophrenia spectrum disorder (SIB), and 44 healthy controls (HC) of either sex. Probabilistic tractography was used to quantify structural connectivity between thalamus and six cortical regions of interest. Thalamocortical structural connectivity was compared among the three groups using cross-thalamic and voxel-wise approaches. Thalamo-prefrontal structural connectivity was reduced in both SZ and SIB relative to HC, while SZ and SIB did not differ from each other. Thalamo-motor structural connectivity was increased in SZ relative to SIB and HC, while SIB and HC did not differ from each other. Hemispheric differences also emerged in thalamic connectivity with motor, posterior parietal, and temporal cortices across all groups. The results support the hypothesis that altered thalamo-prefrontal structural connectivity is a general marker of vulnerability to schizophrenia, whereas altered connectivity between thalamus and motor cortex is related to illness expression or illness-related secondary factors." @default.
• W3046391612 created "2020-08-07" @default.
• W3046391612 creator A5019618579 @default.
• W3046391612 creator A5031613969 @default.
• W3046391612 creator A5046741879 @default.
• W3046391612 creator A5070584453 @default.
• W3046391612 date "2020-01-01" @default.
• W3046391612 modified "2023-10-16" @default.
• W3046391612 title "Altered thalamocortical structural connectivity in persons with schizophrenia and healthy siblings" @default.
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• W3046391612 doi "https://doi.org/10.1016/j.nicl.2020.102370" @default.
• W3046391612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7451425" @default.
• W3046391612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32798913" @default.
• W3046391612 hasPublicationYear "2020" @default.
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