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- W3046394049 abstract "Abstract Inhaled corticosteroids (ICS) are often prescribed for worsening breathlessness, exacerbation frequency or lung function in chronic obstructive pulmonary disease (COPD). In mild-moderate disease and infrequent exacerbations, treatment risks may outweigh benefits and ICS may be withdrawn safely under supervision. A systematic ICS deprescribing programme for patients with mild-moderate COPD was introduced in an east London Clinical Commissioning Group (CCG) in April 2017. Primary care patient record analysis found that prescribing fell from 34.9% ( n = 701) in the 18 months pre-intervention to 26.9% ( n = 538) by the second year of implementation, decreasing 0.84% per quarter post intervention ( p = 0.006, linear regression). The relative decrease was greater than the comparison CCG (23.0% vs. 9.9%). Only South Asian ethnicity was associated with increased cessation (odds ratio 1.48, confidence interval (CI) 1.09–2.01), p = 0.013, logistic regression). Patient outcome data were not collected. A primary care-led programme comprising local education, financial incentivisation and consultant support led to a significant decrease in ICS prescribing." @default.
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- W3046394049 date "2020-07-31" @default.
- W3046394049 modified "2023-09-24" @default.
- W3046394049 title "Reducing the use of inhaled corticosteroids in mild-moderate COPD: an observational study in east London" @default.
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- W3046394049 doi "https://doi.org/10.1038/s41533-020-00191-y" @default.
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