Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046394585> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3046394585 endingPage "2345" @default.
- W3046394585 startingPage "2339" @default.
- W3046394585 abstract "To investigate the effects of omega-3 fatty acids and punctal plugs on tear film and ocular surface parameters in patients receiving systemic isotretinoin therapy.This is a prospective randomized study that included 180 eyes of 90 patients who had systemic isotretinoin therapy (120-150 mg/kg for at least 4-6 months). Exclusion criteria: DED according to the diagnostic criteria of TFOS DEWS II. Patients were assigned into three groups; (1) O3FAs/PPs group: A soft preloaded silicone plug was inserted in the inferior punctum of both eyes and received oral O3FAs two capsules twice daily total daily dose of 1040 mg/day for 6 months. (2) PPs group: A soft preloaded silicone plug was inserted in the inferior punctum of both eyes and received oral placebo. (3) Isotretinoin group: No intervention was done. At baseline, 1 week, 1, 3, and 6 months of study, Ocular surface evaluation tests were done in following order: OSDI, tear osmolarity, Schirmer's I test, TBUT, ocular surface staining score, and meibomian gland expression.The changes in measurement of ocular surface evaluation tests including ocular surface disease index (OSDI), tear film breakup time (TFBUT), corneal staining, tear osmolarity, and meibomian gland expression at 6 months.There are significant changes between all groups at 6 months follow-up. The ocular surface parameters were better for the PPs and O3FAs/PPs groups than the isotretinoin group. The isotretinoin group showed worsening of ocular surface parameters including a significant decrease of FTBUT and an increase of OSDI score, corneal staining score, tear osmolarity, and meibomian expression score. There was no significant difference in ST1 throughout the whole study in all groups. At 6 months follow-up, there were no statistically significant differences between PPs and O3FAs/PPs groups except meibomian expression score which showed a significant increase in PPs group.Our cohort highlights the beneficial effects of the combination of O3FAs supplementation with PPs in the prevention of isotretinoin-associated OSD in this sample study." @default.
- W3046394585 created "2020-08-07" @default.
- W3046394585 creator A5015715283 @default.
- W3046394585 date "2020-07-28" @default.
- W3046394585 modified "2023-10-12" @default.
- W3046394585 title "Efficacy of omega-3 fatty acids and punctal plugs in the prevention of isotretinoin-associated ocular surface disease" @default.
- W3046394585 cites W1517342721 @default.
- W3046394585 cites W1646112310 @default.
- W3046394585 cites W1963589361 @default.
- W3046394585 cites W1969801895 @default.
- W3046394585 cites W1972358883 @default.
- W3046394585 cites W1981351886 @default.
- W3046394585 cites W1992829681 @default.
- W3046394585 cites W2006297880 @default.
- W3046394585 cites W2008187828 @default.
- W3046394585 cites W2020078559 @default.
- W3046394585 cites W2024054650 @default.
- W3046394585 cites W2046176994 @default.
- W3046394585 cites W2064947126 @default.
- W3046394585 cites W2088119156 @default.
- W3046394585 cites W2126039574 @default.
- W3046394585 cites W2155910067 @default.
- W3046394585 cites W2169871850 @default.
- W3046394585 cites W2276726626 @default.
- W3046394585 cites W2287835762 @default.
- W3046394585 cites W2289895447 @default.
- W3046394585 cites W2320620337 @default.
- W3046394585 cites W2322619274 @default.
- W3046394585 cites W2341079225 @default.
- W3046394585 cites W2398108838 @default.
- W3046394585 cites W2407020784 @default.
- W3046394585 cites W2407609685 @default.
- W3046394585 cites W2493099616 @default.
- W3046394585 cites W2547255159 @default.
- W3046394585 cites W2579921739 @default.
- W3046394585 cites W2583361049 @default.
- W3046394585 cites W2606996707 @default.
- W3046394585 cites W2615185451 @default.
- W3046394585 cites W2738160893 @default.
- W3046394585 cites W2739861184 @default.
- W3046394585 cites W2791710565 @default.
- W3046394585 cites W2799761341 @default.
- W3046394585 cites W2806302491 @default.
- W3046394585 cites W2887843846 @default.
- W3046394585 cites W2895960357 @default.
- W3046394585 cites W2911515920 @default.
- W3046394585 cites W2968245105 @default.
- W3046394585 doi "https://doi.org/10.1177/1120672120945655" @default.
- W3046394585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32722939" @default.
- W3046394585 hasPublicationYear "2020" @default.
- W3046394585 type Work @default.
- W3046394585 sameAs 3046394585 @default.
- W3046394585 citedByCount "7" @default.
- W3046394585 countsByYear W30463945852021 @default.
- W3046394585 countsByYear W30463945852022 @default.
- W3046394585 countsByYear W30463945852023 @default.
- W3046394585 crossrefType "journal-article" @default.
- W3046394585 hasAuthorship W3046394585A5015715283 @default.
- W3046394585 hasConcept C118487528 @default.
- W3046394585 hasConcept C141071460 @default.
- W3046394585 hasConcept C16005928 @default.
- W3046394585 hasConcept C2776285725 @default.
- W3046394585 hasConcept C2777165675 @default.
- W3046394585 hasConcept C2777673923 @default.
- W3046394585 hasConcept C2778275304 @default.
- W3046394585 hasConcept C2781302119 @default.
- W3046394585 hasConcept C71924100 @default.
- W3046394585 hasConceptScore W3046394585C118487528 @default.
- W3046394585 hasConceptScore W3046394585C141071460 @default.
- W3046394585 hasConceptScore W3046394585C16005928 @default.
- W3046394585 hasConceptScore W3046394585C2776285725 @default.
- W3046394585 hasConceptScore W3046394585C2777165675 @default.
- W3046394585 hasConceptScore W3046394585C2777673923 @default.
- W3046394585 hasConceptScore W3046394585C2778275304 @default.
- W3046394585 hasConceptScore W3046394585C2781302119 @default.
- W3046394585 hasConceptScore W3046394585C71924100 @default.
- W3046394585 hasIssue "5" @default.
- W3046394585 hasLocation W30463945851 @default.
- W3046394585 hasLocation W30463945852 @default.
- W3046394585 hasOpenAccess W3046394585 @default.
- W3046394585 hasPrimaryLocation W30463945851 @default.
- W3046394585 hasRelatedWork W1983371565 @default.
- W3046394585 hasRelatedWork W2003736806 @default.
- W3046394585 hasRelatedWork W2027614408 @default.
- W3046394585 hasRelatedWork W2032642662 @default.
- W3046394585 hasRelatedWork W2147160167 @default.
- W3046394585 hasRelatedWork W2529717042 @default.
- W3046394585 hasRelatedWork W3031318450 @default.
- W3046394585 hasRelatedWork W3130605362 @default.
- W3046394585 hasRelatedWork W3134271791 @default.
- W3046394585 hasRelatedWork W62547175 @default.
- W3046394585 hasVolume "31" @default.
- W3046394585 isParatext "false" @default.
- W3046394585 isRetracted "false" @default.
- W3046394585 magId "3046394585" @default.
- W3046394585 workType "article" @default.