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• W3046405280 endingPage "194613" @default.
• W3046405280 startingPage "194613" @default.
• W3046405280 abstract "From yeast to human, the Spt-Ada-GCN5-acetyltransferase (SAGA) gigantic complex modifies chromatin during RNA polymerase II initiation and elongation steps to facilitate transcription. Its enzymatic activity involves a histone acetyltransferase module (HATm) that acetylates multiple lysine residues on the N-terminal tails of histones H2B and H3 and a deubiquitination module (DUBm) that triggers co-transcriptional deubiquitination of histone H2B. With a few notable exceptions described in this review, most SAGA subunits identified in yeast and metazoa are present in plants. Studies from the last 20 years have unveiled that different SAGA subunits are involved in gene expression regulation during the plant life cycle and in response to various types of stress or environmental cues. Their functional analysis in the Arabidopsis thaliana model species is increasingly shedding light on their intrinsic properties and how they can themselves be regulated during plant adaptive responses. Recent biochemical studies have also uncovered multiple associations between plant SAGA and chromatin machineries linked to RNA Pol II transcription. Still, considerably less is known about the molecular links between SAGA or SAGA-like complexes and chromatin dynamics during transcription in Arabidopsis and other plant species. We summarize the emerging knowledge on plant SAGA complex composition and activity, with a particular focus on the best-characterized subunits from its HAT (such as GCN5) and DUB (such as UBP22) modules, and implication of these ensembles in plant development and adaptive responses." @default.
• W3046405280 created "2020-08-07" @default.
• W3046405280 creator A5003367094 @default.
• W3046405280 creator A5017339531 @default.
• W3046405280 creator A5047602605 @default.
• W3046405280 date "2021-02-01" @default.
• W3046405280 modified "2023-10-16" @default.
• W3046405280 title "Multifaceted activities of the plant SAGA complex" @default.
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• W3046405280 doi "https://doi.org/10.1016/j.bbagrm.2020.194613" @default.
• W3046405280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32745625" @default.
• W3046405280 hasPublicationYear "2021" @default.
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