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- W3046416941 abstract "Abstract Objective The aim of the study was to characterize the epidemiology and treatment outcomes of head and neck (HN) osseous‐site tumors. Methods Descriptive analyses and multivariate Cox regressions were performed to analyze the effect of surgery on overall survival (OS) utilizing the National Cancer Database (2004‐2016). Results Of 2449 tumors, surgery was utilized in 84.5% of cases. OS was worse in osteosarcoma (5‐year OS: 53.4% [SE: 2.5%]) compared with cartilage tumors (5‐year OS: 84.6% [SE: 1.8%]) (log‐rank P < .001). Treatment regimens that included surgery were associated with improved OS on multivariate analysis (hazard ratio [HR] 0.495 [95% CI: 0.366‐0.670]). Positive margins were found in 40.8% of cases, and associated with decreased OS in osteosarcomas (HR 1.304 [0.697‐2.438]). Conclusion Treatment that included surgery was associated with an increased OS within our cohort of HN osseous‐site tumors, although the rates of positive margins were >40%. These findings may be limited by inherent selection bias in the database." @default.
- W3046416941 created "2020-08-07" @default.
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- W3046416941 date "2020-08-02" @default.
- W3046416941 modified "2023-09-26" @default.
- W3046416941 title "The epidemiology, surgical management, and impact of margins in skull and mandibular osseous‐site tumors" @default.
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- W3046416941 doi "https://doi.org/10.1002/hed.26389" @default.
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