Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046430786> ?p ?o ?g. }
- W3046430786 endingPage "9123" @default.
- W3046430786 startingPage "9109" @default.
- W3046430786 abstract "Abstract Nuclear factor erythroid 2-related factor 2 (NRF2) is a well-characterized transcription factor that protects cells against oxidative and electrophilic stresses. Emerging evidence has suggested that NRF2 protects cells against DNA damage by mechanisms other than antioxidation, yet the mechanism remains poorly understood. Here, we demonstrate that knockout of NRF2 in cells results in hypersensitivity to ionizing radiation (IR) in the presence or absence of reactive oxygen species (ROS). Under ROS scavenging conditions, induction of DNA double-strand breaks (DSBs) increases the NRF2 protein level and recruits NRF2 to DNA damage sites where it interacts with ATR, resulting in activation of the ATR–CHK1–CDC2 signaling pathway. In turn, this leads to G2 cell cycle arrest and the promotion of homologous recombination repair of DSBs, thereby preserving genome stability. The inhibition of NRF2 by brusatol increased the radiosensitivity of tumor cells in xenografts by perturbing ATR and CHK1 activation. Collectively, our results reveal a novel function of NRF2 as an ATR activator in the regulation of the cellular response to DSBs. This shift in perspective should help furnish a more complete understanding of the function of NRF2 and the DNA damage response." @default.
- W3046430786 created "2020-08-07" @default.
- W3046430786 creator A5003642180 @default.
- W3046430786 creator A5005715243 @default.
- W3046430786 creator A5009105017 @default.
- W3046430786 creator A5022310050 @default.
- W3046430786 creator A5023363049 @default.
- W3046430786 creator A5031315906 @default.
- W3046430786 creator A5057055806 @default.
- W3046430786 creator A5062045949 @default.
- W3046430786 creator A5063795630 @default.
- W3046430786 creator A5076341654 @default.
- W3046430786 creator A5077458329 @default.
- W3046430786 creator A5088017610 @default.
- W3046430786 date "2020-07-30" @default.
- W3046430786 modified "2023-10-17" @default.
- W3046430786 title "NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest" @default.
- W3046430786 cites W1421415727 @default.
- W3046430786 cites W1752089945 @default.
- W3046430786 cites W1841331176 @default.
- W3046430786 cites W1923812684 @default.
- W3046430786 cites W1967630574 @default.
- W3046430786 cites W1990230487 @default.
- W3046430786 cites W1993920050 @default.
- W3046430786 cites W2000206408 @default.
- W3046430786 cites W2004352006 @default.
- W3046430786 cites W2008280357 @default.
- W3046430786 cites W2010711320 @default.
- W3046430786 cites W2018458310 @default.
- W3046430786 cites W2020062139 @default.
- W3046430786 cites W2025229552 @default.
- W3046430786 cites W2030749349 @default.
- W3046430786 cites W2034702779 @default.
- W3046430786 cites W2040898650 @default.
- W3046430786 cites W2043080981 @default.
- W3046430786 cites W2043895957 @default.
- W3046430786 cites W2053063855 @default.
- W3046430786 cites W2057124829 @default.
- W3046430786 cites W2065588235 @default.
- W3046430786 cites W2068077324 @default.
- W3046430786 cites W2077950988 @default.
- W3046430786 cites W2080155284 @default.
- W3046430786 cites W2083431317 @default.
- W3046430786 cites W2083675699 @default.
- W3046430786 cites W2092328174 @default.
- W3046430786 cites W2093814864 @default.
- W3046430786 cites W2094125478 @default.
- W3046430786 cites W2099676698 @default.
- W3046430786 cites W2101520349 @default.
- W3046430786 cites W2111131079 @default.
- W3046430786 cites W2119346494 @default.
- W3046430786 cites W2134807701 @default.
- W3046430786 cites W2144836619 @default.
- W3046430786 cites W2145200068 @default.
- W3046430786 cites W2146204567 @default.
- W3046430786 cites W2146741358 @default.
- W3046430786 cites W2149468013 @default.
- W3046430786 cites W2150140277 @default.
- W3046430786 cites W2152440925 @default.
- W3046430786 cites W2155324869 @default.
- W3046430786 cites W2157685861 @default.
- W3046430786 cites W2161699458 @default.
- W3046430786 cites W2168891919 @default.
- W3046430786 cites W2168973737 @default.
- W3046430786 cites W2469619651 @default.
- W3046430786 cites W2469918555 @default.
- W3046430786 cites W2513264496 @default.
- W3046430786 cites W2530188477 @default.
- W3046430786 cites W2531549933 @default.
- W3046430786 cites W2558818939 @default.
- W3046430786 cites W2609630616 @default.
- W3046430786 cites W2625452721 @default.
- W3046430786 cites W2754122880 @default.
- W3046430786 cites W2774093317 @default.
- W3046430786 cites W2801988573 @default.
- W3046430786 cites W2806142898 @default.
- W3046430786 cites W763311227 @default.
- W3046430786 cites W767415338 @default.
- W3046430786 doi "https://doi.org/10.1093/nar/gkaa631" @default.
- W3046430786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7498319" @default.
- W3046430786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32729622" @default.
- W3046430786 hasPublicationYear "2020" @default.
- W3046430786 type Work @default.
- W3046430786 sameAs 3046430786 @default.
- W3046430786 citedByCount "47" @default.
- W3046430786 countsByYear W30464307862020 @default.
- W3046430786 countsByYear W30464307862021 @default.
- W3046430786 countsByYear W30464307862022 @default.
- W3046430786 countsByYear W30464307862023 @default.
- W3046430786 crossrefType "journal-article" @default.
- W3046430786 hasAuthorship W3046430786A5003642180 @default.
- W3046430786 hasAuthorship W3046430786A5005715243 @default.
- W3046430786 hasAuthorship W3046430786A5009105017 @default.
- W3046430786 hasAuthorship W3046430786A5022310050 @default.
- W3046430786 hasAuthorship W3046430786A5023363049 @default.
- W3046430786 hasAuthorship W3046430786A5031315906 @default.
- W3046430786 hasAuthorship W3046430786A5057055806 @default.
- W3046430786 hasAuthorship W3046430786A5062045949 @default.