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- W3046455300 endingPage "5563" @default.
- W3046455300 startingPage "5563" @default.
- W3046455300 abstract "Which pathogenic mechanisms underlie age-related macular degeneration (AMD)? Are they different for dry and wet variants, or do they stem from common metabolic alterations? Where shall we look for altered metabolism? Is it the inner choroid, or is it rather the choroid–retinal border? Again, since cell-clearing pathways are crucial to degrade altered proteins, which metabolic system is likely to be the most implicated, and in which cell type? Here we describe the unique clearing activity of the retinal pigment epithelium (RPE) and the relevant role of its autophagy machinery in removing altered debris, thus centering the RPE in the pathogenesis of AMD. The cell-clearing systems within the RPE may act as a kernel to regulate the redox homeostasis and the traffic of multiple proteins and organelles toward either the choroid border or the outer segments of photoreceptors. This is expected to cope with the polarity of various domains within RPE cells, with each one owning a specific metabolic activity. A defective clearance machinery may trigger unconventional solutions to avoid intracellular substrates’ accumulation through unconventional secretions. These components may be deposited between the RPE and Bruch’s membrane, thus generating the drusen, which remains the classic hallmark of AMD. These deposits may rather represent a witness of an abnormal RPE metabolism than a real pathogenic component. The empowerment of cell clearance, antioxidant, anti-inflammatory, and anti-angiogenic activity of the RPE by specific phytochemicals is here discussed." @default.
- W3046455300 created "2020-08-07" @default.
- W3046455300 creator A5001716460 @default.
- W3046455300 creator A5002108536 @default.
- W3046455300 creator A5032656853 @default.
- W3046455300 creator A5032981915 @default.
- W3046455300 creator A5067003625 @default.
- W3046455300 creator A5067262146 @default.
- W3046455300 creator A5086738716 @default.
- W3046455300 date "2020-08-03" @default.
- W3046455300 modified "2023-10-10" @default.
- W3046455300 title "A Re-Appraisal of Pathogenic Mechanisms Bridging Wet and Dry Age-Related Macular Degeneration Leads to Reconsider a Role for Phytochemicals" @default.
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