Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046509208> ?p ?o ?g. }
- W3046509208 endingPage "1103" @default.
- W3046509208 startingPage "1093" @default.
- W3046509208 abstract "Background:: Alfuzosin is recently co-formulated with solifenacin for relieving two coincident urological diseases, namely; benign prostate hyperplasia and overactive bladder. Objective:: Herein, green, simple and rapid spectrophotometric methods were firstly developed for simultaneous determination of the two cited drugs in their co-formulated pharmaceutical capsule Methods:: Alfuzosin, which is the major component in the dosage form, was directly assayed at its extended wavelength at 330.0 nm. The challenging spectrum of the minor component, solifenacin, was resolved by five spectrophotometric methods, namely; Dual Wavelength (DW) at 210.0 & 230.0 nm, first derivative ( 1 D) at 222.0 nm, Ratio Difference (RD) at 217.0 - 271.0 nm , derivative ratio ( 1 DD) at 223.0 and mean centering of ratio spectra (MC) at 217.0 nm. Results:: The proposed methods were successfully validated as per ICH guidelines. Alfuzosin showed linearity over the range of 4.0 - 70.0 μg/mL, while that of solifenacin were 4.0 - 50.0 μg/mL for DW, 2.0 - 70.0 μg/mL for 1 D and RD methods, 1.0 - 70.0 μg/mL for 1 DD and 4.0 - 70.0 μg/mL for MC method. Statistical comparison with their official ones showed no noticeable differences. The methods showed good applicability for assaying drugs in their newly combination. Besides the eco-scale, the greenness profile of the methods was assessed and compared with the reported spectrophotometric one via the newest metric tool; Green Analytical Procedure Index (GAPI). Conclusions:: The proposed methods are superior in not only being smart, accurate, selective, robust and time-saving, but also in using distilled water as an eco-friendly and cheap solvent." @default.
- W3046509208 created "2020-08-07" @default.
- W3046509208 creator A5011360052 @default.
- W3046509208 creator A5043057371 @default.
- W3046509208 creator A5051368801 @default.
- W3046509208 creator A5060691945 @default.
- W3046509208 date "2021-09-01" @default.
- W3046509208 modified "2023-10-13" @default.
- W3046509208 title "Eco-friendly Spectrophotometric Methods for Assessment of Alfuzosin and Solifenacin in their new Pharmaceutical Formulation; Green Profile Evaluation via Eco-scale and GAPI Tools" @default.
- W3046509208 cites W1132256446 @default.
- W3046509208 cites W1503376607 @default.
- W3046509208 cites W1971176683 @default.
- W3046509208 cites W1975812734 @default.
- W3046509208 cites W1979733155 @default.
- W3046509208 cites W1993670486 @default.
- W3046509208 cites W1996842820 @default.
- W3046509208 cites W2011746657 @default.
- W3046509208 cites W2032595039 @default.
- W3046509208 cites W2034944462 @default.
- W3046509208 cites W2036062821 @default.
- W3046509208 cites W2042934068 @default.
- W3046509208 cites W2043672469 @default.
- W3046509208 cites W2071402005 @default.
- W3046509208 cites W2078329955 @default.
- W3046509208 cites W2086243679 @default.
- W3046509208 cites W2089340678 @default.
- W3046509208 cites W2093686204 @default.
- W3046509208 cites W2110353553 @default.
- W3046509208 cites W2118959164 @default.
- W3046509208 cites W2129244925 @default.
- W3046509208 cites W2131036251 @default.
- W3046509208 cites W2139287008 @default.
- W3046509208 cites W2163088733 @default.
- W3046509208 cites W2234532599 @default.
- W3046509208 cites W2323768014 @default.
- W3046509208 cites W2409551901 @default.
- W3046509208 cites W2525922186 @default.
- W3046509208 cites W2593779116 @default.
- W3046509208 cites W2595752563 @default.
- W3046509208 cites W2754335707 @default.
- W3046509208 cites W2766008620 @default.
- W3046509208 cites W2766844879 @default.
- W3046509208 cites W2781931056 @default.
- W3046509208 cites W2790304806 @default.
- W3046509208 cites W2792408324 @default.
- W3046509208 cites W2801463333 @default.
- W3046509208 cites W2885033735 @default.
- W3046509208 cites W2889188769 @default.
- W3046509208 cites W2896914384 @default.
- W3046509208 cites W2908593289 @default.
- W3046509208 cites W2922129016 @default.
- W3046509208 cites W2958534783 @default.
- W3046509208 cites W2980234226 @default.
- W3046509208 cites W3021093547 @default.
- W3046509208 cites W3036856247 @default.
- W3046509208 cites W400118018 @default.
- W3046509208 cites W4382140810 @default.
- W3046509208 cites W2045031957 @default.
- W3046509208 doi "https://doi.org/10.2174/1573412916999200730005740" @default.
- W3046509208 hasPublicationYear "2021" @default.
- W3046509208 type Work @default.
- W3046509208 sameAs 3046509208 @default.
- W3046509208 citedByCount "12" @default.
- W3046509208 countsByYear W30465092082022 @default.
- W3046509208 countsByYear W30465092082023 @default.
- W3046509208 crossrefType "journal-article" @default.
- W3046509208 hasAuthorship W3046509208A5011360052 @default.
- W3046509208 hasAuthorship W3046509208A5043057371 @default.
- W3046509208 hasAuthorship W3046509208A5051368801 @default.
- W3046509208 hasAuthorship W3046509208A5060691945 @default.
- W3046509208 hasConcept C113196181 @default.
- W3046509208 hasConcept C121608353 @default.
- W3046509208 hasConcept C126322002 @default.
- W3046509208 hasConcept C142724271 @default.
- W3046509208 hasConcept C185592680 @default.
- W3046509208 hasConcept C204787440 @default.
- W3046509208 hasConcept C2776235491 @default.
- W3046509208 hasConcept C2778941218 @default.
- W3046509208 hasConcept C2779478474 @default.
- W3046509208 hasConcept C2779502394 @default.
- W3046509208 hasConcept C2780546585 @default.
- W3046509208 hasConcept C43617362 @default.
- W3046509208 hasConcept C71924100 @default.
- W3046509208 hasConceptScore W3046509208C113196181 @default.
- W3046509208 hasConceptScore W3046509208C121608353 @default.
- W3046509208 hasConceptScore W3046509208C126322002 @default.
- W3046509208 hasConceptScore W3046509208C142724271 @default.
- W3046509208 hasConceptScore W3046509208C185592680 @default.
- W3046509208 hasConceptScore W3046509208C204787440 @default.
- W3046509208 hasConceptScore W3046509208C2776235491 @default.
- W3046509208 hasConceptScore W3046509208C2778941218 @default.
- W3046509208 hasConceptScore W3046509208C2779478474 @default.
- W3046509208 hasConceptScore W3046509208C2779502394 @default.
- W3046509208 hasConceptScore W3046509208C2780546585 @default.
- W3046509208 hasConceptScore W3046509208C43617362 @default.
- W3046509208 hasConceptScore W3046509208C71924100 @default.
- W3046509208 hasIssue "8" @default.
- W3046509208 hasLocation W30465092081 @default.