Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046520281> ?p ?o ?g. }
- W3046520281 abstract "Abstract Nigella sativa, Carica papaya and Boswellia sacra are medicinal plants in the commonly used in folkloric medicine due to the presence of its immense therapeutic properties. Fifty (50) female albino mice weighing between 15-22g were divided into five groups of 10 mice each. Animal in group 1 served as control group and were administered distilled water while animal in group 2 were given 2ml of cisplatin (orally). Animal in group 3-5 were given orally; 100 mg/kg (low dose), 200 mg/kg (medium dose) and 400 mg/kg (high dose) of triherbal preparation. The feeding regimens lasted for 28 days. After 28 days, mammary gland and blood samples were collected for haematological and antioxidant analysis. The triherbal formula decreased the GSH and MDA levels of mice treated with 100 mg/kg and 400 mg/kg doses compare to control. The measurement of total protein content, SOD and CAT increased in treated animals compared to control. However, RBC (Red Blood Cell) counts significantly decreased in the low, medium and high dose groups (0.95±0.08, 6.57±0.08 and 3.55±0.55 x 10 6 cells/mm 3 respectively) compared to control (7.34±0.40) at P<0.05. Also, significant decreases (P<0.05) in the level of the total WBC (White Blood Cell) count, platelet count, PCV (Packed Cell Volume) and Hb (haemoglobin) concentration were observed. The decreases were dose dependent. The MCH (Mean Corpuscular Haemoglobin) and MCHC (Mean Corpuscular Haemoglobin Concentration) except MCV (Mean Corpuscular Volume) significantly decreased in treated group only. The triherbal formulation exhibited significant antioxidant activities showing increased levels of SOD, CAT and Protein content due to activation of the enzyme involve in detoxification of free radicals and decreased in the level of GSH and MDA due to accumulation of peroxides and H 2 O 2 . Also, decreased in haematological parameters due to the presence of phytochemicals such as phenol, resins, saponins, sterols, tannis and terpenes in the triherbal formula. Therefore, it has potential to induce haematotoxicity hence consumption of high concentrations should be discouraged." @default.
- W3046520281 created "2020-08-07" @default.
- W3046520281 creator A5031349469 @default.
- W3046520281 creator A5038252832 @default.
- W3046520281 creator A5041051157 @default.
- W3046520281 creator A5074130397 @default.
- W3046520281 creator A5084892767 @default.
- W3046520281 date "2020-08-04" @default.
- W3046520281 modified "2023-09-27" @default.
- W3046520281 title "Evaluation Of Biochemical, Hematological And Antioxidant Properties In Mice Exposed To A Triherbal (Nigella sativa, Carica papaya and Boswellia sacra) Formular" @default.
- W3046520281 cites W1802867416 @default.
- W3046520281 cites W1894555385 @default.
- W3046520281 cites W191793640 @default.
- W3046520281 cites W1964738530 @default.
- W3046520281 cites W1965509195 @default.
- W3046520281 cites W1965606785 @default.
- W3046520281 cites W1965609450 @default.
- W3046520281 cites W1975649659 @default.
- W3046520281 cites W1976768321 @default.
- W3046520281 cites W1978940151 @default.
- W3046520281 cites W1981471144 @default.
- W3046520281 cites W1983194258 @default.
- W3046520281 cites W1983310681 @default.
- W3046520281 cites W1985360755 @default.
- W3046520281 cites W1987704691 @default.
- W3046520281 cites W1995456813 @default.
- W3046520281 cites W1996645723 @default.
- W3046520281 cites W2003628443 @default.
- W3046520281 cites W2007195740 @default.
- W3046520281 cites W2009532513 @default.
- W3046520281 cites W2017952084 @default.
- W3046520281 cites W2021399542 @default.
- W3046520281 cites W2030664827 @default.
- W3046520281 cites W2032451592 @default.
- W3046520281 cites W2035726240 @default.
- W3046520281 cites W2037335018 @default.
- W3046520281 cites W2045881105 @default.
- W3046520281 cites W2048326161 @default.
- W3046520281 cites W2048604010 @default.
- W3046520281 cites W2051814376 @default.
- W3046520281 cites W2051989112 @default.
- W3046520281 cites W2052526882 @default.
- W3046520281 cites W2066099456 @default.
- W3046520281 cites W2066751961 @default.
- W3046520281 cites W2069132215 @default.
- W3046520281 cites W2069886199 @default.
- W3046520281 cites W2070613674 @default.
- W3046520281 cites W2072629310 @default.
- W3046520281 cites W2077801717 @default.
- W3046520281 cites W2081886240 @default.
- W3046520281 cites W2091648971 @default.
- W3046520281 cites W2094150627 @default.
- W3046520281 cites W2094585179 @default.
- W3046520281 cites W2094751617 @default.
- W3046520281 cites W2097353642 @default.
- W3046520281 cites W2101422765 @default.
- W3046520281 cites W2115692424 @default.
- W3046520281 cites W2119068203 @default.
- W3046520281 cites W2125682093 @default.
- W3046520281 cites W2138110658 @default.
- W3046520281 cites W2148427775 @default.
- W3046520281 cites W2150217973 @default.
- W3046520281 cites W2157114690 @default.
- W3046520281 cites W2159127902 @default.
- W3046520281 cites W2160161230 @default.
- W3046520281 cites W2169501969 @default.
- W3046520281 cites W2398037642 @default.
- W3046520281 cites W2765598274 @default.
- W3046520281 cites W2796217087 @default.
- W3046520281 cites W4245219249 @default.
- W3046520281 cites W4254066522 @default.
- W3046520281 doi "https://doi.org/10.1101/2020.08.02.233635" @default.
- W3046520281 hasPublicationYear "2020" @default.
- W3046520281 type Work @default.
- W3046520281 sameAs 3046520281 @default.
- W3046520281 citedByCount "1" @default.
- W3046520281 countsByYear W30465202812021 @default.
- W3046520281 crossrefType "posted-content" @default.
- W3046520281 hasAuthorship W3046520281A5031349469 @default.
- W3046520281 hasAuthorship W3046520281A5038252832 @default.
- W3046520281 hasAuthorship W3046520281A5041051157 @default.
- W3046520281 hasAuthorship W3046520281A5074130397 @default.
- W3046520281 hasAuthorship W3046520281A5084892767 @default.
- W3046520281 hasBestOaLocation W30465202811 @default.
- W3046520281 hasConcept C140793950 @default.
- W3046520281 hasConcept C185592680 @default.
- W3046520281 hasConcept C203014093 @default.
- W3046520281 hasConcept C2778004101 @default.
- W3046520281 hasConcept C2778488018 @default.
- W3046520281 hasConcept C2778917026 @default.
- W3046520281 hasConcept C2779231358 @default.
- W3046520281 hasConcept C2779429693 @default.
- W3046520281 hasConcept C2781058662 @default.
- W3046520281 hasConcept C2993714443 @default.
- W3046520281 hasConcept C43617362 @default.
- W3046520281 hasConcept C55493867 @default.
- W3046520281 hasConcept C556039675 @default.
- W3046520281 hasConcept C59822182 @default.
- W3046520281 hasConcept C71924100 @default.
- W3046520281 hasConcept C86803240 @default.